Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ctsb

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CTSB
- Mouse genes Ctsb
- Rat genes Ctsb
- Zfish genes ctsba,ctsbb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ctsb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005518	collagen binding	CTSB	IDA		Human	PMID:22952693
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CTSB	IDA		Human	PMID:22952693
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CTSB	IDA		Human	PMID:6203523
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Ctsb	IDA		Mouse	PMID:30487519
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Ctsb	IDA		Rat	PMID:12788072\|RGD:12793045
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Ctsb	IDA		Rat	PMID:16960372\|RGD:2315574
Molecular Function	GO:0008234	cysteine-type peptidase activity	CTSB	IDA		Human	PMID:8612130
Molecular Function	GO:0008234	cysteine-type peptidase activity	CTSB	IDA		Human	PMID:8811434
Molecular Function	GO:0008234	cysteine-type peptidase activity	Ctsb	IDA		Mouse	PMID:28728022
Molecular Function	GO:0004175	endopeptidase activity	Ctsb	IMP		Mouse	MGI:MGI:6274956\|PMID:28835281
Molecular Function	GO:0004175	endopeptidase activity	Ctsb	IDA		Rat	PMID:11687729\|RGD:1600623
Molecular Function	GO:0004175	endopeptidase activity	Ctsb	IDA		Rat	PMID:8702598\|RGD:1625498
Molecular Function	GO:0004175	endopeptidase activity	Ctsb	IMP		Rat	PMID:8717430\|RGD:1625507
Molecular Function	GO:0030984	kininogen binding	Ctsb	IPI	RGD:2980	Rat	PMID:3356189\|RGD:1600550
Molecular Function	GO:0008233	peptidase activity	CTSB	IDA		Human	PMID:7890620
Molecular Function	GO:0042277	peptide binding	Ctsb	IDA		Rat	PMID:8702598\|RGD:1625498
Molecular Function	GO:0005515	protein binding	CTSB	IPI	UniProtKB:P0C045	Human	PMID:16237761
Molecular Function	GO:0005515	protein binding	CTSB	IPI	UniProtKB:P02760	Human	PMID:16364318
Molecular Function	GO:0005515	protein binding	CTSB	IPI	UniProtKB:Q6UY14	Human	PMID:16364318
Molecular Function	GO:0005515	protein binding	CTSB	IPI	UniProtKB:Q9NYA1	Human	PMID:17064696
Molecular Function	GO:0005515	protein binding	CTSB	IPI	UniProtKB:O60687	Human	PMID:18718938
Molecular Function	GO:0005515	protein binding	CTSB	IPI	UniProtKB:P40692	Human	PMID:20706999
Molecular Function	GO:0005515	protein binding	CTSB	IPI	UniProtKB:Q96IK1-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSB	IPI	UniProtKB:P01034	Human	PMID:6203523
Molecular Function	GO:0005515	protein binding	CTSB	IPI	UniProtKB:P01034	Human	PMID:7890620
Molecular Function	GO:0005515	protein binding	CTSB	IPI	UniProtKB:P28325	Human	PMID:8083219
Molecular Function	GO:0005515	protein binding	Ctsb	IPI	RGD:620817	Rat	PMID:18938146\|RGD:2315506
Molecular Function	GO:0043621	protein self-association	Ctsb	IDA		Rat	PMID:7550115\|RGD:5686403
Molecular Function	GO:0044877	protein-containing complex binding	Ctsb	IPI	RGD:2447\|RGD:2448\|RGD:628643	Rat	PMID:2470410\|RGD:2315535
Molecular Function	GO:0043394	proteoglycan binding	CTSB	IPI	UniProtKB:Q05793	Human	PMID:22952693
Cellular Component	GO:0016324	apical plasma membrane	Ctsb	IDA		Rat	PMID:12432075\|RGD:734525
Cellular Component	GO:0005901	caveola	Ctsb	IDA		Rat	PMID:16497156\|RGD:1599532
Cellular Component	GO:0009986	cell surface	Ctsb	IDA		Rat	PMID:12432075\|RGD:734525
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSB	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSB	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSB	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSB	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Ctsb	HDA		Mouse	MGI:MGI:6201853\|PMID:28071719
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Ctsb	HDA		Mouse	MGI:MGI:6201834\|PMID:22159717
Cellular Component	GO:0005737	cytoplasm	Ctsb	IDA		Rat	PMID:19941836\|RGD:2315502
Cellular Component	GO:0009897	external side of plasma membrane	Ctsb	IDA		Mouse	MGI:MGI:2664014\|PMID:12782676
Cellular Component	GO:0009897	external side of plasma membrane	Ctsb	IDA		Rat	PMID:2432075\|RGD:728174
Cellular Component	GO:0070062	extracellular exosome	CTSB	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	CTSB	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	Ctsb	IDA		Rat	PMID:12432075\|RGD:734525
Cellular Component	GO:0005615	extracellular space	CTSB	IDA		Human	PMID:22952693
Cellular Component	GO:0005615	extracellular space	Ctsb	HDA		Mouse	MGI:MGI:5640941\|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Ctsb	IDA		Mouse	MGI:MGI:2664014\|PMID:12782676
Cellular Component	GO:0005615	extracellular space	Ctsb	IDA		Rat	PMID:19958779\|RGD:2315501
Cellular Component	GO:0005615	extracellular space	Ctsb	IDA		Rat	PMID:2005374\|RGD:5686400
Cellular Component	GO:0005764	lysosome	CTSB	IDA		Human	PMID:1837142
Cellular Component	GO:0005764	lysosome	CTSB	IDA		Human	PMID:2350688
Cellular Component	GO:0005764	lysosome	Ctsb	IDA		Mouse	MGI:MGI:2664014\|PMID:12782676
Cellular Component	GO:0005764	lysosome	Ctsb	IDA		Mouse	PMID:9034150
Cellular Component	GO:0005764	lysosome	Ctsb	IDA		Rat	PMID:11687729\|RGD:1600623
Cellular Component	GO:0005764	lysosome	Ctsb	IDA		Rat	PMID:11788364\|RGD:631244
Cellular Component	GO:0005764	lysosome	Ctsb	IDA		Rat	PMID:12432075\|RGD:734525
Cellular Component	GO:0005764	lysosome	Ctsb	IDA		Rat	PMID:19696938\|RGD:2315504
Cellular Component	GO:0005764	lysosome	Ctsb	IDA		Rat	PMID:8702598\|RGD:1625498
Cellular Component	GO:0005739	mitochondrion	Ctsb	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Ctsb	IDA		Rat	PMID:18938146\|RGD:2315506
Cellular Component	GO:1904090	peptidase inhibitor complex	CTSB	IPI		Human	PMID:20860624
Cellular Component	GO:0048471	perinuclear region of cytoplasm	CTSB	IDA		Human	PMID:15614436
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Ctsb	IDA		Rat	PMID:17218008\|RGD:2315728
Cellular Component	GO:0042383	sarcolemma	Ctsb	IDA		Rat	PMID:7043996\|RGD:2315538
Biological Process	GO:0006914	autophagy	Ctsb	IEP		Rat	PMID:18567942\|RGD:2315511
Biological Process	GO:0071260	cellular response to mechanical stimulus	Ctsb	IEP		Rat	PMID:18464888\|RGD:2315512
Biological Process	GO:0097067	cellular response to thyroid hormone stimulus	CTSB	IEP		Human	PMID:21217776
Biological Process	GO:0030574	collagen catabolic process	CTSB	IDA		Human	PMID:22952693
Biological Process	GO:0060026	convergent extension	ctsba	IMP	ZFIN:ZDB-GENO-160713-1	Zfish	PMID:26893345
Biological Process	GO:0046697	decidualization	Ctsb	IGI	MGI:MGI:88564	Mouse	PMID:9310336
Biological Process	GO:0009953	dorsal/ventral pattern formation	ctsba	IMP	ZFIN:ZDB-GENO-160713-1	Zfish	PMID:26893345
Biological Process	GO:0090504	epiboly	ctsba	IMP	ZFIN:ZDB-GENO-160713-1	Zfish	PMID:26893345
Biological Process	GO:0030855	epithelial cell differentiation	CTSB	IEP		Human	PMID:21492153
Biological Process	GO:0031101	fin regeneration	ctsba	IEP		Zfish	PMID:22278371
Biological Process	GO:0010466	negative regulation of peptidase activity	CTSB	IDA		Human	PMID:20860624
Biological Process	GO:0051402	neuron apoptotic process	Ctsb	IMP		Rat	PMID:19420257\|RGD:2315505
Biological Process	GO:0030163	protein catabolic process	Ctsb	IDA		Rat	PMID:11687729\|RGD:1600623
Biological Process	GO:0030163	protein catabolic process	Ctsb	IDA		Rat	PMID:11788364\|RGD:631244
Biological Process	GO:0030163	protein catabolic process	Ctsb	IDA		Rat	PMID:8702598\|RGD:1625498
Biological Process	GO:0030163	protein catabolic process	Ctsb	IDA		Rat	PMID:8717430\|RGD:1625507
Biological Process	GO:0006508	proteolysis	CTSB	IDA		Human	PMID:7890620
Biological Process	GO:0006508	proteolysis	CTSB	IDA		Human	PMID:8811434
Biological Process	GO:0006508	proteolysis	Ctsb	IDA		Rat	PMID:12788072\|RGD:12793045
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	CTSB	IDA		Human	PMID:22952693
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	Ctsb	IMP		Mouse	MGI:MGI:2664014\|PMID:12782676
Biological Process	GO:0014075	response to amine	Ctsb	IEP		Rat	PMID:17371271\|RGD:2315519
Biological Process	GO:0034097	response to cytokine	Ctsb	IEP		Rat	PMID:19893052\|RGD:2315503
Biological Process	GO:0071548	response to dexamethasone	Ctsb	IEP		Rat	PMID:8717430\|RGD:1625507
Biological Process	GO:0045471	response to ethanol	Ctsb	IEP		Rat	PMID:17935147\|RGD:2307058
Biological Process	GO:0009749	response to glucose	Ctsb	IEP		Rat	PMID:14722017\|RGD:2315529
Biological Process	GO:0070670	response to interleukin-4	Ctsb	IEP		Rat	PMID:18464888\|RGD:2315512
Biological Process	GO:0009612	response to mechanical stimulus	Ctsb	IEP		Rat	PMID:17379854\|RGD:2315518
Biological Process	GO:0014070	response to organic cyclic compound	Ctsb	IEP		Rat	PMID:18094625\|RGD:2315514
Biological Process	GO:0043434	response to peptide hormone	Ctsb	IEP		Rat	PMID:18676994\|RGD:2315509
Biological Process	GO:0009611	response to wounding	Ctsb	IEP		Rat	PMID:15817261\|RGD:1358684
Biological Process	GO:0007519	skeletal muscle tissue development	Ctsb	IEP		Rat	PMID:16497156\|RGD:1599532
Biological Process	GO:0007283	spermatogenesis	Ctsb	IEP		Rat	PMID:9238520\|RGD:5686401
Biological Process	GO:0006590	thyroid hormone generation	Ctsb	IMP		Mouse	MGI:MGI:2664014\|PMID:12782676
Biological Process	GO:0046718	viral entry into host cell	Ctsb	IMP		Mouse	MGI:MGI:5640952\|PMID:15831716

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.