Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CTSC
  • Mouse genes Ctsc
  • Rat genes Ctsc
  • Zfish genes ctsc
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ctsc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031404	chloride ion binding	Ctsc	IDA		Rat	PMID:11602245|RGD:1599641
Molecular Function	GO:0008234	cysteine-type peptidase activity	CTSC	IDA		Human	PMID:1586157
Molecular Function	GO:0008234	cysteine-type peptidase activity	CTSC	IDA		Human	PMID:8428921
Molecular Function	GO:0008234	cysteine-type peptidase activity	CTSC	IDA		Human	PMID:8811434
Molecular Function	GO:0008234	cysteine-type peptidase activity	Ctsc	IDA		Mouse	PMID:28251676
Molecular Function	GO:0042802	identical protein binding	Ctsc	IDA		Rat	PMID:11602245|RGD:1599641
Molecular Function	GO:0016505	peptidase activator activity involved in apoptotic process	Ctsc	IGI	MGI:MGI:107285	Mouse	PMID:20435891
Molecular Function	GO:0019902	phosphatase binding	Ctsc	IPI	UniProtKB:P09923	Rat	PMID:18307834|RGD:8661625
Molecular Function	GO:0005515	protein binding	CTSC	IPI	UniProtKB:O76096	Human	PMID:18256700
Molecular Function	GO:0005515	protein binding	CTSC	IPI	UniProtKB:G5E9A7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSC	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0043621	protein self-association	Ctsc	IDA		Rat	PMID:11602245|RGD:1599641
Molecular Function	GO:0051087	protein-folding chaperone binding	Ctsc	IPI	UniProtKB:P63018	Rat	PMID:18307834|RGD:8661625
Molecular Function	GO:0004252	serine-type endopeptidase activity	Ctsc	IMP		Mouse	MGI:MGI:4838939|PMID:20435891
Cellular Component	GO:0005813	centrosome	CTSC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSC	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Ctsc	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0005737	cytoplasm	Ctsc	IDA		Mouse	PMID:28251676
Cellular Component	GO:0005783	endoplasmic reticulum	Ctsc	IDA		Rat	PMID:4065148|RGD:1599650
Cellular Component	GO:0070062	extracellular exosome	CTSC	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CTSC	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	CTSC	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	CTSC	HDA		Human	PMID:16502470
Cellular Component	GO:0005794	Golgi apparatus	Ctsc	IDA		Rat	PMID:4065148|RGD:1599650
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CTSC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005764	lysosome	Ctsc	IDA		Rat	PMID:18307834|RGD:8661625
Cellular Component	GO:0005764	lysosome	Ctsc	IDA		Rat	PMID:8215389|RGD:1599644
Cellular Component	GO:0016020	membrane	CTSC	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	CTSC	IDA		Human	GO_REF:0000052
Biological Process	GO:0007568	aging	Ctsc	IEP		Rat	PMID:3094018|RGD:1599647
Biological Process	GO:0031642	negative regulation of myelination	Ctsc	IDA		Mouse	PMID:28251676
Biological Process	GO:0031642	negative regulation of myelination	Ctsc	IMP	MGI:MGI:5910745	Mouse	PMID:28251676
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	Ctsc	IGI	MGI:MGI:107285	Mouse	PMID:20435891
Biological Process	GO:1903980	positive regulation of microglial cell activation	Ctsc	IDA		Mouse	PMID:28251676
Biological Process	GO:1903052	positive regulation of proteolysis involved in protein catabolic process	Ctsc	IDA		Rat	PMID:18307834|RGD:8661625
Biological Process	GO:0006508	proteolysis	CTSC	IDA		Human	PMID:8811434
Biological Process	GO:0006508	proteolysis	Ctsc	IMP		Mouse	MGI:MGI:4838939|PMID:20435891
Biological Process	GO:0010033	response to organic substance	Ctsc	IDA		Rat	PMID:11367515|RGD:1599642
Biological Process	GO:0001913	T cell mediated cytotoxicity	Ctsc	IGI	UniProtKB:P49935	Mouse	MGI:MGI:4838939|PMID:20435891

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern