Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CTSD
  • Mouse genes Ctsd
  • Rat genes Ctsd
  • Zfish genes ctsd
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ctsd

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	Ctsd	IDA		Mouse	PMID:19293336
Molecular Function	GO:0070001	aspartic-type peptidase activity	Ctsd	IMP		Mouse	MGI:MGI:6294182|PMID:16997486
Molecular Function	GO:0004175	endopeptidase activity	Ctsd	IDA		Mouse	PMID:27703010
Molecular Function	GO:0004175	endopeptidase activity	Ctsd	IDA		Mouse	PMID:26467158
Molecular Function	GO:0004175	endopeptidase activity	Ctsd	IDA		Rat	PMID:11687729|RGD:1600623
Molecular Function	GO:0004175	endopeptidase activity	Ctsd	IDA		Rat	PMID:12666874|RGD:1299317
Molecular Function	GO:0004175	endopeptidase activity	Ctsd	IDA		Rat	PMID:8702598|RGD:1625498
Molecular Function	GO:0004175	endopeptidase activity	Ctsd	IMP		Rat	PMID:8717430|RGD:1625507
Molecular Function	GO:0016787	hydrolase activity	Ctsd	IDA		Mouse	PMID:19710420
Molecular Function	GO:0008233	peptidase activity	CTSD	IDA		Human	PMID:16997486
Molecular Function	GO:0008233	peptidase activity	CTSD	IMP		Human	PMID:17188016
Molecular Function	GO:0008233	peptidase activity	Ctsd	IDA		Mouse	PMID:15588329
Molecular Function	GO:0008233	peptidase activity	Ctsd	IDA		Mouse	PMID:16423528
Molecular Function	GO:0042277	peptide binding	Ctsd	IDA		Rat	PMID:8702598|RGD:1625498
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:P05067	Human	PMID:17112520
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:P28799	Human	PMID:28493053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:P28799:PRO_0000012695	Human	PMID:28493053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:P28799:PRO_0000012696	Human	PMID:28493053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:P28799:PRO_0000012697	Human	PMID:28493053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:P28799:PRO_0000012698	Human	PMID:28493053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:P28799:PRO_0000012699	Human	PMID:28493053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:P28799:PRO_0000012700	Human	PMID:28493053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:P28799:PRO_0000012701	Human	PMID:28493053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:I6L9I8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:O00308	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:O15130-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:P09565	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:P28347-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:P45880	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:P68431	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:Q12756	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:Q15007-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:Q5TA79	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:Q5W0Z9-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:Q6ZNH5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:Q7Z602	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:Q86VF5-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:Q8NBJ7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:Q96LB9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:Q9BQG1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:Q9C004	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:Q9H6S3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:Q9P1A6-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSD	IPI	UniProtKB:Q9Y6F6-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Ctsd	IPI	UniProtKB:P28799	Mouse	MGI:MGI:5907533|PMID:28453791
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSD	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSD	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSD	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSD	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Ctsd	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0031904	endosome lumen	Ctsd	IDA		Mouse	PMID:27703010
Cellular Component	GO:0010008	endosome membrane	CTSD	IDA		Human	PMID:17188016
Cellular Component	GO:0070062	extracellular exosome	CTSD	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CTSD	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	CTSD	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	CTSD	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	CTSD	HDA		Human	PMID:20551380
Cellular Component	GO:0005615	extracellular space	Ctsd	IDA		Mouse	PMID:19710420
Cellular Component	GO:0098982	GABA-ergic synapse	Ctsd	IDA		Rat	PMID:31340140|RGD:155230699
Cellular Component	GO:0005765	lysosomal membrane	CTSD	IDA		Human	PMID:17188016
Cellular Component	GO:0005764	lysosome	CTSD	IDA		Human	PMID:1692625
Cellular Component	GO:0005764	lysosome	CTSD	IDA		Human	PMID:1837142
Cellular Component	GO:0005764	lysosome	CTSD	IDA		Human	PMID:19723497
Cellular Component	GO:0005764	lysosome	CTSD	IDA		Human	PMID:2350688
Cellular Component	GO:0005764	lysosome	Ctsd	IDA		Mouse	MGI:MGI:5701557|PMID:26370502
Cellular Component	GO:0005764	lysosome	Ctsd	IDA		Mouse	PMID:12775715
Cellular Component	GO:0005764	lysosome	Ctsd	IDA		Mouse	PMID:28504966
Cellular Component	GO:0005764	lysosome	Ctsd	IDA		Mouse	PMID:9645704
Cellular Component	GO:0005764	lysosome	Ctsd	IDA		Mouse	PMID:10591619
Cellular Component	GO:0005764	lysosome	Ctsd	IDA		Mouse	PMID:16242638
Cellular Component	GO:0005764	lysosome	Ctsd	IDA		Mouse	PMID:12676993
Cellular Component	GO:0005764	lysosome	Ctsd	IDA		Mouse	PMID:9034150
Cellular Component	GO:0005764	lysosome	Ctsd	IDA		Mouse	PMID:15452145
Cellular Component	GO:0005764	lysosome	Ctsd	IDA		Rat	PMID:11687729|RGD:1600623
Cellular Component	GO:0005764	lysosome	Ctsd	IDA		Rat	PMID:12666874|RGD:1299317
Cellular Component	GO:0005764	lysosome	Ctsd	IDA		Rat	PMID:8702598|RGD:1625498
Cellular Component	GO:0045121	membrane raft	CTSD	IDA		Human	PMID:25204797
Cellular Component	GO:0005739	mitochondrion	Ctsd	HDA		Mouse	PMID:14651853
Cellular Component	GO:0098830	presynaptic endosome	Ctsd	IDA		Rat	PMID:31340140|RGD:155230699
Biological Process	GO:0000045	autophagosome assembly	Ctsd	IMP		Mouse	PMID:15452145
Biological Process	GO:1901143	insulin catabolic process	Ctsd	IDA		Mouse	PMID:27703010
Biological Process	GO:0038020	insulin receptor recycling	Ctsd	IDA		Mouse	PMID:27703010
Biological Process	GO:0042159	lipoprotein catabolic process	CTSD	IDA		Human	PMID:16997486
Biological Process	GO:0061061	muscle structure development	ctsd	IMP	ZFIN:ZDB-MRPHLNO-110722-1	Zfish	PMID:23464837
Biological Process	GO:0043065	positive regulation of apoptotic process	CTSD	IDA		Human	PMID:12107093
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	CTSD	IDA		Human	PMID:12107093
Biological Process	GO:0030163	protein catabolic process	Ctsd	IDA		Rat	PMID:12666874|RGD:1299317
Biological Process	GO:0006508	proteolysis	CTSD	IDA		Human	PMID:16997486
Biological Process	GO:0006508	proteolysis	CTSD	IMP		Human	PMID:17188016
Biological Process	GO:0070201	regulation of establishment of protein localization	CTSD	IDA		Human	PMID:12107093
Biological Process	GO:0009617	response to bacterium	ctsd	IDA		Zfish	PMID:15829308
Biological Process	GO:0031667	response to nutrient levels	Ctsd	IEP		Rat	PMID:17665967|RGD:1643198
Biological Process	GO:0003406	retinal pigment epithelium development	ctsd	IMP	ZFIN:ZDB-MRPHLNO-110722-1	Zfish	PMID:21747967

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern