Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ctsh

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CTSH
- Mouse genes Ctsh
- Rat genes Ctsh
- Zfish genes ctsh
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ctsh

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004177	aminopeptidase activity	CTSH	IDA		Human	PMID:15127951
Molecular Function	GO:0004177	aminopeptidase activity	Ctsh	IDA		Rat	PMID:1483460\|RGD:5686404
Molecular Function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	CTSH	IDA		Human	PMID:20435891
Molecular Function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	Ctsh	IGI	UniProtKB:P97821	Mouse	MGI:MGI:4838939\|PMID:20435891
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CTSH	IDA		Human	PMID:6203523
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Ctsh	IDA		Mouse	MGI:MGI:3722010\|PMID:17500053
Molecular Function	GO:0008234	cysteine-type peptidase activity	CTSH	IDA		Human	PMID:8811434
Molecular Function	GO:0004175	endopeptidase activity	CTSH	IDA		Human	PMID:14766755
Molecular Function	GO:0004175	endopeptidase activity	CTSH	IDA		Human	PMID:15127951
Molecular Function	GO:0004175	endopeptidase activity	Ctsh	IMP		Mouse	MGI:MGI:5306315\|PMID:14766755
Molecular Function	GO:0030108	HLA-A specific activating MHC class I receptor activity	CTSH	IDA		Human	PMID:16822283
Molecular Function	GO:0030984	kininogen binding	Ctsh	IPI	RGD:2980	Rat	PMID:3356189\|RGD:1600550
Molecular Function	GO:0016505	peptidase activator activity involved in apoptotic process	Ctsh	IGI	MGI:MGI:109553	Mouse	PMID:20435891
Molecular Function	GO:0008233	peptidase activity	CTSH	IDA		Human	PMID:18216060
Molecular Function	GO:0005515	protein binding	CTSH	IPI	UniProtKB:P01034	Human	PMID:15127951
Molecular Function	GO:0005515	protein binding	CTSH	IPI	UniProtKB:Q14204	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSH	IPI	UniProtKB:Q86V38	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSH	IPI	UniProtKB:Q92876	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CTSH	IPI	UniProtKB:P01034	Human	PMID:6203523
Molecular Function	GO:0005515	protein binding	CTSH	IPI	UniProtKB:P01040	Human	PMID:6203523
Molecular Function	GO:0005515	protein binding	CTSH	IPI	UniProtKB:P04080	Human	PMID:6203523
Molecular Function	GO:0043621	protein self-association	Ctsh	IDA		Rat	PMID:7550115\|RGD:5686403
Molecular Function	GO:0044877	protein-containing complex binding	Ctsh	IPI	RGD:628643\|RGD:2447\|RGD:621509	Rat	PMID:2470410\|RGD:2315535
Molecular Function	GO:0004252	serine-type endopeptidase activity	Ctsh	IMP		Mouse	MGI:MGI:4838939\|PMID:20435891
Molecular Function	GO:0070324	thyroid hormone binding	CTSH	IDA		Human	PMID:21217776
Cellular Component	GO:0001669	acrosomal vesicle	Ctsh	IDA		Rat	PMID:12838426\|RGD:5686399
Cellular Component	GO:0097208	alveolar lamellar body	CTSH	IDA		Human	PMID:18216060
Cellular Component	GO:0097208	alveolar lamellar body	Ctsh	IDA		Rat	PMID:12034564\|RGD:727636
Cellular Component	GO:0097208	alveolar lamellar body	Ctsh	IDA		Rat	PMID:2005374\|RGD:5686400
Cellular Component	GO:0005930	axoneme	Ctsh	IDA		Rat	PMID:12838426\|RGD:5686399
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSH	HDA		Human	PMID:25037231
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	CTSH	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	CTSH	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	CTSH	IDA		Human	PMID:9050938
Cellular Component	GO:0070062	extracellular exosome	CTSH	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	CTSH	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	CTSH	IDA		Human	PMID:18216060
Cellular Component	GO:0005615	extracellular space	CTSH	IDA		Human	PMID:21217776
Cellular Component	GO:0005615	extracellular space	CTSH	IDA		Human	PMID:9050938
Cellular Component	GO:0005615	extracellular space	Ctsh	IDA		Rat	PMID:2005374\|RGD:5686400
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CTSH	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005764	lysosome	CTSH	IDA		Human	PMID:15196205
Cellular Component	GO:0005764	lysosome	CTSH	IDA		Human	PMID:16822283
Cellular Component	GO:0005764	lysosome	CTSH	IDA		Human	PMID:1837142
Cellular Component	GO:0005764	lysosome	Ctsh	IDA		Rat	PMID:2005374\|RGD:5686400
Cellular Component	GO:0001520	outer dense fiber	Ctsh	IDA		Rat	PMID:12838426\|RGD:5686399
Biological Process	GO:0002250	adaptive immune response	CTSH	IEP		Human	PMID:15196205
Biological Process	GO:0006915	apoptotic process	Ctsh	IGI	MGI:MGI:109553	Mouse	MGI:MGI:4838939\|PMID:20435891
Biological Process	GO:0010815	bradykinin catabolic process	CTSH	IDA		Human	PMID:15127951
Biological Process	GO:0097067	cellular response to thyroid hormone stimulus	CTSH	IEP		Human	PMID:21217776
Biological Process	GO:0097067	cellular response to thyroid hormone stimulus	Ctsh	IEP		Rat	PMID:21217776\|RGD:8553996
Biological Process	GO:0060448	dichotomous subdivision of terminal units involved in lung branching	Ctsh	IMP		Mouse	MGI:MGI:3722010\|PMID:17500053
Biological Process	GO:0070371	ERK1 and ERK2 cascade	CTSH	IDA		Human	PMID:21217776
Biological Process	GO:0002764	immune response-regulating signaling pathway	CTSH	IDA		Human	PMID:16822283
Biological Process	GO:0033619	membrane protein proteolysis	CTSH	IDA		Human	PMID:14766755
Biological Process	GO:0033619	membrane protein proteolysis	Ctsh	IMP		Mouse	MGI:MGI:5306315\|PMID:14766755
Biological Process	GO:0001656	metanephros development	Ctsh	IEP		Rat	PMID:16153003\|RGD:8554708
Biological Process	GO:0043066	negative regulation of apoptotic process	Ctsh	IMP		Mouse	MGI:MGI:5306553\|PMID:20731543
Biological Process	GO:0010813	neuropeptide catabolic process	CTSH	IDA		Human	PMID:15127951
Biological Process	GO:0045766	positive regulation of angiogenesis	Ctsh	IMP		Mouse	MGI:MGI:5306553\|PMID:20731543
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	Ctsh	IGI	MGI:MGI:109553	Mouse	PMID:20435891
Biological Process	GO:0030335	positive regulation of cell migration	CTSH	IDA		Human	PMID:21217776
Biological Process	GO:0008284	positive regulation of cell population proliferation	Ctsh	IMP		Mouse	MGI:MGI:5306553\|PMID:20731543
Biological Process	GO:0010634	positive regulation of epithelial cell migration	Ctsh	IMP		Mouse	MGI:MGI:3722010\|PMID:17500053
Biological Process	GO:0010628	positive regulation of gene expression	CTSH	IDA		Human	PMID:21217776
Biological Process	GO:0010952	positive regulation of peptidase activity	CTSH	IDA		Human	PMID:20435891
Biological Process	GO:0010952	positive regulation of peptidase activity	Ctsh	IGI	UniProtKB:P97821	Mouse	MGI:MGI:4838939\|PMID:20435891
Biological Process	GO:0031648	protein destabilization	CTSH	IMP		Human	PMID:17500053
Biological Process	GO:0031648	protein destabilization	Ctsh	IMP		Mouse	MGI:MGI:3722010\|PMID:17500053
Biological Process	GO:0006508	proteolysis	CTSH	IDA		Human	PMID:6203523
Biological Process	GO:0006508	proteolysis	CTSH	IDA		Human	PMID:8811434
Biological Process	GO:0006508	proteolysis	Ctsh	IMP		Mouse	MGI:MGI:4838939\|PMID:20435891
Biological Process	GO:1990834	response to odorant	Ctsh	IEP		Rat	PMID:23103411\|RGD:11530015
Biological Process	GO:0032526	response to retinoic acid	Ctsh	IDA		Mouse	MGI:MGI:3722010\|PMID:17500053
Biological Process	GO:0007283	spermatogenesis	Ctsh	IEP		Rat	PMID:9238520\|RGD:5686401
Biological Process	GO:0043129	surfactant homeostasis	CTSH	IDA		Human	PMID:18216060
Biological Process	GO:0001913	T cell mediated cytotoxicity	Ctsh	IGI	UniProtKB:P97821	Mouse	MGI:MGI:4838939\|PMID:20435891
Biological Process	GO:0031638	zymogen activation	CTSH	IDA		Human	PMID:20435891
Biological Process	GO:0031638	zymogen activation	Ctsh	IMP		Mouse	MGI:MGI:4838939\|PMID:20435891

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.