Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CTSK
  • Mouse genes Ctsk
  • Rat genes Ctsk
  • Zfish genes ctsk
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ctsk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005518	collagen binding	CTSK	IDA		Human	PMID:22952693
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CTSK	IDA		Human	PMID:22952693
Molecular Function	GO:0008234	cysteine-type peptidase activity	CTSK	IDA		Human	PMID:19834056
Molecular Function	GO:0001968	fibronectin binding	CTSK	IPI	UniProtKB:P02751	Human	PMID:22952693
Molecular Function	GO:0005515	protein binding	CTSK	IPI	UniProtKB:Q9UIV8	Human	PMID:12504904
Molecular Function	GO:0043394	proteoglycan binding	CTSK	IPI	UniProtKB:Q05793	Human	PMID:22952693
Cellular Component	GO:0005737	cytoplasm	Ctsk	IDA		Rat	PMID:14585819|RGD:1354673
Cellular Component	GO:0009897	external side of plasma membrane	Ctsk	IDA		Mouse	MGI:MGI:2664014|PMID:12782676
Cellular Component	GO:0005615	extracellular space	CTSK	IDA		Human	PMID:11082042
Cellular Component	GO:0005615	extracellular space	CTSK	IDA		Human	PMID:22952693
Cellular Component	GO:0005615	extracellular space	Ctsk	IDA		Mouse	MGI:MGI:2664014|PMID:12782676
Cellular Component	GO:0005615	extracellular space	Ctsk	IDA		Rat	PMID:16261450|RGD:1601023
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CTSK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005764	lysosome	CTSK	IDA		Human	PMID:11082042
Cellular Component	GO:0005764	lysosome	CTSK	IDA		Human	PMID:22365146
Cellular Component	GO:0005764	lysosome	Ctsk	IDA		Mouse	MGI:MGI:2664014|PMID:12782676
Cellular Component	GO:0005764	lysosome	Ctsk	IDA		Mouse	PMID:29514215
Cellular Component	GO:0005764	lysosome	Ctsk	IDA		Rat	PMID:14585819|RGD:1354673
Cellular Component	GO:0005654	nucleoplasm	CTSK	IDA		Human	GO_REF:0000052
Biological Process	GO:0000422	autophagy of mitochondrion	CTSK	HMP		Human	PMID:24912190
Biological Process	GO:0060348	bone development	ctsk	IGI	ZFIN:ZDB-GENE-030131-4714	Zfish	PMID:26404503
Biological Process	GO:0045453	bone resorption	Ctsk	IMP	MGI:MGI:2182131	Mouse	PMID:19834056
Biological Process	GO:0045453	bone resorption	Ctsk	IMP		Rat	PMID:10430032|RGD:1601030
Biological Process	GO:0051216	cartilage development	ctsk	IGI	ZFIN:ZDB-GENE-030131-4714	Zfish	PMID:26404503
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Ctsk	IEP		Rat	PMID:23110133|RGD:151665477
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Ctsk	IEP		Rat	PMID:23110133|RGD:151665477
Biological Process	GO:0034224	cellular response to zinc ion starvation	Ctsk	IEP		Rat	PMID:21893222|RGD:151667428
Biological Process	GO:0030574	collagen catabolic process	CTSK	IDA		Human	PMID:19834056
Biological Process	GO:0030574	collagen catabolic process	CTSK	IDA		Human	PMID:22952693
Biological Process	GO:0030574	collagen catabolic process	Ctsk	IMP	MGI:MGI:2182131	Mouse	PMID:19834056
Biological Process	GO:0001957	intramembranous ossification	Ctsk	IEP		Rat	PMID:16193234|RGD:1601024
Biological Process	GO:1903131	mononuclear cell differentiation	Ctsk	IEP		Rat	PMID:23110133|RGD:151665477
Biological Process	GO:0061037	negative regulation of cartilage development	Ctsk	IMP	MGI:MGI:2182131	Mouse	PMID:19834056
Biological Process	GO:0006508	proteolysis	Ctsk	IDA		Rat	PMID:21893222|RGD:151667428
Biological Process	GO:0006508	proteolysis	Ctsk	IDA		Rat	PMID:22576626|RGD:151667429
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	CTSK	IDA		Human	PMID:11082042
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	CTSK	IDA		Human	PMID:22952693
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	Ctsk	IMP		Mouse	MGI:MGI:2664014|PMID:12782676
Biological Process	GO:0045471	response to ethanol	Ctsk	IEP		Rat	PMID:22576626|RGD:151667429
Biological Process	GO:0032868	response to insulin	Ctsk	IEP		Rat	PMID:20818503|RGD:151667419
Biological Process	GO:0009612	response to mechanical stimulus	ctsk	IDA		Zfish	PMID:23632157
Biological Process	GO:0014070	response to organic cyclic compound	Ctsk	IEP		Rat	PMID:20818503|RGD:151667419
Biological Process	GO:0006590	thyroid hormone generation	CTSK	IDA		Human	PMID:11082042
Biological Process	GO:0006590	thyroid hormone generation	Ctsk	IMP		Mouse	MGI:MGI:2664014|PMID:12782676

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern