Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ctsl

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CTSL,CTSV
- Mouse genes Ctsl
- Rat genes Ctsl
- Zfish genes ctsla,ctslb,ctsll,si:dkey-239j18.2,si:dkey-239j18.3,si:dkey-269i1.4,zgc:174153,zgc:174154,zgc:174855
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ctsl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004177	aminopeptidase activity	Ctsl	IDA		Rat	PMID:11687729\|RGD:1600623
Molecular Function	GO:0004177	aminopeptidase activity	Ctsl	IDA		Rat	PMID:11788364\|RGD:631244
Molecular Function	GO:0004177	aminopeptidase activity	Ctsl	IDA		Rat	PMID:8702598\|RGD:1625498
Molecular Function	GO:0005518	collagen binding	CTSL	IDA		Human	PMID:22952693
Molecular Function	GO:0016807	cysteine-type carboxypeptidase activity	Ctsl	IDA		Mouse	PMID:11023992
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CTSL	IDA		Human	PMID:12809493
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CTSL	IDA		Human	PMID:14511383
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CTSL	IDA		Human	PMID:22952693
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CTSL	IMP		Human	PMID:28743268
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Ctsl	IDA		Rat	PMID:12788072\|RGD:12793045
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Ctsl	IDA		Rat	PMID:16960372\|RGD:2315574
Molecular Function	GO:0008234	cysteine-type peptidase activity	CTSL	IDA		Human	PMID:8811434
Molecular Function	GO:0004175	endopeptidase activity	Ctsl	IMP		Mouse	MGI:MGI:6274956\|PMID:28835281
Molecular Function	GO:0004175	endopeptidase activity	Ctsl	IMP	MGI:MGI:2136432	Mouse	PMID:18450756
Molecular Function	GO:0001968	fibronectin binding	CTSL	IPI	UniProtKB:P02751	Human	PMID:22952693
Molecular Function	GO:0042393	histone binding	CTSL	IDA		Human	PMID:21326229
Molecular Function	GO:0042393	histone binding	Ctsl	IDA		Mouse	MGI:MGI:5009377\|PMID:18957203
Molecular Function	GO:0030984	kininogen binding	Ctsl	IPI	RGD:2980	Rat	PMID:3356189\|RGD:1600550
Molecular Function	GO:0042277	peptide binding	Ctsl	IDA		Rat	PMID:8702598\|RGD:1625498
Molecular Function	GO:0005515	protein binding	CTSV	IPI	UniProtKB:Q9UIV8	Human	PMID:12809493
Molecular Function	GO:0005515	protein binding	CTSL	IPI	UniProtKB:Q9UIV8	Human	PMID:12504904
Molecular Function	GO:0005515	protein binding	CTSL	IPI	UniProtKB:Q9UIV8	Human	PMID:12809493
Molecular Function	GO:0005515	protein binding	CTSL	IPI	UniProtKB:G5EFH4	Human	PMID:17889653
Molecular Function	GO:0005515	protein binding	CTSL	IPI	UniProtKB:O43765	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CTSL	IPI	UniProtKB:P0DTC2	Human	PMID:32512386
Molecular Function	GO:0005515	protein binding	CTSL	IPI	UniProtKB:P59594	Human	PMID:32512386
Molecular Function	GO:0005515	protein binding	CTSL	IPI	UniProtKB:P0DTC2	Human	PMID:33774649
Molecular Function	GO:0005515	protein binding	CTSL	IPI	UniProtKB:P59594	Human	PMID:33774649
Molecular Function	GO:0005515	protein binding	Ctsl	IPI	UniProtKB:P04441-1	Mouse	MGI:MGI:6259330\|PMID:12417635
Molecular Function	GO:0005515	protein binding	Ctsl	IPI	UniProtKB:P04441-1	Mouse	MGI:MGI:3691984\|PMID:11483509
Molecular Function	GO:0005515	protein binding	Ctsl	IPI	PR:P12400	Mouse	PMID:14681235
Molecular Function	GO:0044877	protein-containing complex binding	Ctsl	IPI	RGD:628643\|RGD:2447\|RGD:621509	Rat	PMID:2470410\|RGD:2315535
Molecular Function	GO:0043394	proteoglycan binding	CTSL	IPI	UniProtKB:Q05793	Human	PMID:22952693
Molecular Function	GO:0097655	serpin family protein binding	CTSL	IPI	UniProtKB:P29508	Human	PMID:21383048
Cellular Component	GO:0045177	apical part of cell	Ctsl	IDA		Rat	PMID:15761664\|RGD:2315594
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSL	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Ctsl	HDA		Mouse	MGI:MGI:6201853\|PMID:28071719
Cellular Component	GO:0005737	cytoplasm	Ctsl	IDA		Rat	PMID:14585819\|RGD:1354673
Cellular Component	GO:0031410	cytoplasmic vesicle	Ctsl	IDA		Mouse	PMID:9310336
Cellular Component	GO:0009897	external side of plasma membrane	Ctsl	IDA		Mouse	MGI:MGI:2664014\|PMID:12782676
Cellular Component	GO:0009897	external side of plasma membrane	Ctsl	IDA		Rat	PMID:19284293\|RGD:2315554
Cellular Component	GO:0070062	extracellular exosome	CTSL	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	ctslb	IDA		Zfish	PMID:11748832
Cellular Component	GO:0005615	extracellular space	CTSL	IDA		Human	PMID:22952693
Cellular Component	GO:0005615	extracellular space	Ctsl	IDA		Mouse	MGI:MGI:6437015\|PMID:10716919
Cellular Component	GO:0005615	extracellular space	Ctsl	IDA		Mouse	MGI:MGI:6259330\|PMID:12417635
Cellular Component	GO:0005615	extracellular space	Ctsl	IDA		Mouse	MGI:MGI:2664014\|PMID:12782676
Cellular Component	GO:0005615	extracellular space	Ctsl	IDA		Mouse	PMID:9310336
Cellular Component	GO:0005794	Golgi apparatus	CTSL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CTSL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005764	lysosome	CTSL	IDA		Human	PMID:15196205
Cellular Component	GO:0005764	lysosome	CTSL	IDA		Human	PMID:1837142
Cellular Component	GO:0005764	lysosome	CTSL	IDA		Human	PMID:22365146
Cellular Component	GO:0005764	lysosome	CTSL	IDA		Human	PMID:28743268
Cellular Component	GO:0005764	lysosome	Ctsl	IDA		Mouse	MGI:MGI:2664014\|PMID:12782676
Cellular Component	GO:0005764	lysosome	Ctsl	IDA		Mouse	MGI:MGI:3691984\|PMID:11483509
Cellular Component	GO:0005764	lysosome	Ctsl	IDA		Mouse	PMID:15099520
Cellular Component	GO:0005764	lysosome	Ctsl	IDA		Mouse	PMID:11023992
Cellular Component	GO:0005764	lysosome	Ctsl	IDA		Rat	PMID:11687729\|RGD:1600623
Cellular Component	GO:0005764	lysosome	Ctsl	IDA		Rat	PMID:11788364\|RGD:631244
Cellular Component	GO:0005764	lysosome	Ctsl	IDA		Rat	PMID:8702598\|RGD:1625498
Cellular Component	GO:0005902	microvillus	Ctsl	IDA		Rat	PMID:15085256\|RGD:2315617
Cellular Component	GO:0005771	multivesicular body	CTSL	IDA		Human	PMID:22365146
Cellular Component	GO:0043005	neuron projection	Ctsl	IDA		Rat	PMID:16176344\|RGD:2315590
Cellular Component	GO:0005730	nucleolus	Ctsl	IDA		Mouse	MGI:MGI:5009356\|PMID:20338168
Cellular Component	GO:0005634	nucleus	Ctsl	IDA		Mouse	MGI:MGI:5009377\|PMID:18957203
Cellular Component	GO:0043204	perikaryon	Ctsl	IDA		Rat	PMID:16176344\|RGD:2315590
Cellular Component	GO:0005886	plasma membrane	CTSL	IDA		Human	PMID:22365146
Cellular Component	GO:0030141	secretory granule	Ctsl	IDA		Rat	PMID:18410501\|RGD:2315564
Cellular Component	GO:0030141	secretory granule	Ctsl	IDA		Rat	PMID:19372204\|RGD:2315552
Cellular Component	GO:0005773	vacuole	Ctsl	IDA		Rat	PMID:16176344\|RGD:2315590
Biological Process	GO:0002250	adaptive immune response	CTSL	IEP		Human	PMID:15196205
Biological Process	GO:0048002	antigen processing and presentation of peptide antigen	Ctsl	IMP		Mouse	MGI:MGI:2655909\|PMID:9545226
Biological Process	GO:0048002	antigen processing and presentation of peptide antigen	Ctsl	IMP		Mouse	MGI:MGI:3655445\|PMID:12021314
Biological Process	GO:0048102	autophagic cell death	Ctsl	IEP		Rat	PMID:16176344\|RGD:2315590
Biological Process	GO:0042637	catagen	Ctsl	IMP	MGI:MGI:2136432	Mouse	PMID:11023992
Biological Process	GO:0043373	CD4-positive, alpha-beta T cell lineage commitment	Ctsl	IMP		Mouse	MGI:MGI:2655909\|PMID:9545226
Biological Process	GO:0007154	cell communication	Ctsl	IDA		Rat	PMID:9876020\|RGD:2315585
Biological Process	GO:0009267	cellular response to starvation	Ctsl	IEP		Rat	PMID:16176344\|RGD:2315590
Biological Process	GO:0097067	cellular response to thyroid hormone stimulus	CTSL	IEP		Human	PMID:21217776
Biological Process	GO:0030574	collagen catabolic process	CTSL	IDA		Human	PMID:10716919
Biological Process	GO:0030574	collagen catabolic process	CTSL	IDA		Human	PMID:22952693
Biological Process	GO:0030574	collagen catabolic process	Ctsl	IDA		Mouse	MGI:MGI:6437015\|PMID:10716919
Biological Process	GO:0046697	decidualization	Ctsl	IGI	MGI:MGI:88561	Mouse	PMID:9310336
Biological Process	GO:0046697	decidualization	Ctsl	IEP		Rat	PMID:15644143\|RGD:2315602
Biological Process	GO:0060309	elastin catabolic process	Ctsl	IMP		Mouse	MGI:MGI:6259330\|PMID:12417635
Biological Process	GO:0039654	fusion of virus membrane with host endosome membrane	CTSL	IDA		Human	PMID:16081529
Biological Process	GO:0039654	fusion of virus membrane with host endosome membrane	CTSL	IDA		Human	PMID:18562523
Biological Process	GO:0019064	fusion of virus membrane with host plasma membrane	CTSL	IDA		Human	PMID:32855215
Biological Process	GO:0031069	hair follicle morphogenesis	Ctsl	IMP	MGI:MGI:2136432	Mouse	PMID:11023992
Biological Process	GO:0043616	keratinocyte proliferation	Ctsl	IMP	MGI:MGI:2136432	Mouse	PMID:11023992
Biological Process	GO:0008584	male gonad development	Ctsl	IEP		Rat	PMID:16135663\|RGD:2315592
Biological Process	GO:0010259	multicellular organism aging	Ctsl	IEP		Rat	PMID:16865413\|RGD:2315581
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	Ctsl	IMP	MGI:MGI:2136432	Mouse	PMID:11023992
Biological Process	GO:0021675	nerve development	Ctsl	IEP		Rat	PMID:15686940\|RGD:2315613
Biological Process	GO:0016540	protein autoprocessing	CTSL	IDA		Human	PMID:9468501
Biological Process	GO:0030163	protein catabolic process	Ctsl	IDA		Rat	PMID:11788364\|RGD:631244
Biological Process	GO:0006508	proteolysis	CTSL	IDA		Human	PMID:21326229
Biological Process	GO:0006508	proteolysis	CTSL	IDA		Human	PMID:8811434
Biological Process	GO:0006508	proteolysis	Ctsl	IDA		Mouse	MGI:MGI:5009377\|PMID:18957203
Biological Process	GO:0006508	proteolysis	Ctsl	IDA		Rat	PMID:12788072\|RGD:12793045
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	CTSL	IDA		Human	PMID:22952693
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	Ctsl	IMP		Mouse	MGI:MGI:2664014\|PMID:12782676
Biological Process	GO:0019065	receptor-mediated endocytosis of virus by host cell	CTSL	IDA		Human	PMID:16081529
Biological Process	GO:0019065	receptor-mediated endocytosis of virus by host cell	CTSL	IDA		Human	PMID:32221306
Biological Process	GO:0019065	receptor-mediated endocytosis of virus by host cell	CTSL	IDA		Human	PMID:32855215
Biological Process	GO:0051384	response to glucocorticoid	Ctsl	IEP		Rat	PMID:15705658\|RGD:1626501
Biological Process	GO:0009749	response to glucose	Ctsl	IEP		Rat	PMID:9877467\|RGD:2315702
Biological Process	GO:0034698	response to gonadotropin	Ctsl	IEP		Rat	PMID:14563703\|RGD:1304448
Biological Process	GO:1990834	response to odorant	Ctsl	IEP		Rat	PMID:23103411\|RGD:11530015
Biological Process	GO:0014070	response to organic cyclic compound	Ctsl	IEP		Rat	PMID:18465118\|RGD:2315561
Biological Process	GO:0060008	Sertoli cell differentiation	Ctsl	IEP		Rat	PMID:15647457\|RGD:1581112
Biological Process	GO:0007283	spermatogenesis	Ctsl	IEP		Rat	PMID:9876020\|RGD:2315585
Biological Process	GO:0006590	thyroid hormone generation	Ctsl	IMP		Mouse	MGI:MGI:2664014\|PMID:12782676
Biological Process	GO:0046718	viral entry into host cell	CTSL	IDA		Human	PMID:16339146
Biological Process	GO:0046718	viral entry into host cell	CTSL	IDA		Human	PMID:18562523
Biological Process	GO:0046718	viral entry into host cell	CTSL	IDA		Human	PMID:26953343
Biological Process	GO:0046718	viral entry into host cell	CTSL	IDA		Human	PMID:32855215
Biological Process	GO:0031638	zymogen activation	CTSL	IDA		Human	PMID:9468501

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.