Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CTSS
  • Mouse genes Ctss
  • Rat genes Ctss
  • Zfish genes ctss1,ctss2.1,ctss2.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ctss

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005518	collagen binding	CTSS	IDA		Human	PMID:22952693
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CTSS	IDA		Human	PMID:12788072
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CTSS	IDA		Human	PMID:22952693
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CTSS	IDA		Human	PMID:8612130
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Ctss	EXP		Mouse	MGI:MGI:3487192|PMID:15308097
Molecular Function	GO:0008234	cysteine-type peptidase activity	Ctss	IDA		Rat	PMID:11570845|RGD:5687154
Molecular Function	GO:0001968	fibronectin binding	CTSS	IPI	UniProtKB:P02751	Human	PMID:22952693
Molecular Function	GO:0043236	laminin binding	CTSS	IDA		Human	PMID:22952693
Molecular Function	GO:0008233	peptidase activity	Ctss	IDA		Mouse	PMID:11854359
Molecular Function	GO:0043394	proteoglycan binding	CTSS	IPI	UniProtKB:Q05793	Human	PMID:22952693
Cellular Component	GO:0009986	cell surface	Ctss	IDA		Rat	PMID:16436681|RGD:5687150
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSS	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSS	HDA		Human	PMID:25037231
Cellular Component	GO:0005615	extracellular space	CTSS	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	CTSS	IDA		Human	PMID:22952693
Cellular Component	GO:0005615	extracellular space	CTSS	IDA		Human	PMID:9524075
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CTSS	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005770	late endosome	CTSS	IDA		Human	PMID:22365146
Cellular Component	GO:0005764	lysosome	CTSS	IDA		Human	PMID:15196205
Cellular Component	GO:0005764	lysosome	Ctss	IDA		Mouse	PMID:29514215
Cellular Component	GO:0005764	lysosome	Ctss	IDA		Mouse	PMID:11854359
Cellular Component	GO:0016020	membrane	Ctss	IDA		Mouse	PMID:11854359
Cellular Component	GO:0045335	phagocytic vesicle	CTSS	IDA		Human	PMID:30612035
Biological Process	GO:0002250	adaptive immune response	CTSS	IEP		Human	PMID:15196205
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	CTSS	IDA		Human	PMID:30612035
Biological Process	GO:0048002	antigen processing and presentation of peptide antigen	CTSS	IDA		Human	PMID:8612130
Biological Process	GO:0034769	basement membrane disassembly	CTSS	IDA		Human	PMID:22952693
Biological Process	GO:0034769	basement membrane disassembly	Ctss	IMP		Mouse	MGI:MGI:5553237|PMID:22952693
Biological Process	GO:0045453	bone resorption	Ctss	IMP		Rat	PMID:10470376|RGD:5687153
Biological Process	GO:0097067	cellular response to thyroid hormone stimulus	CTSS	IEP		Human	PMID:21217776
Biological Process	GO:0030574	collagen catabolic process	CTSS	IDA		Human	PMID:22952693
Biological Process	GO:0001656	metanephros development	Ctss	IEP		Rat	PMID:16153003|RGD:8554708
Biological Process	GO:2001259	positive regulation of cation channel activity	CTSS	IDA		Human	PMID:22864553
Biological Process	GO:2001259	positive regulation of cation channel activity	Ctss	IDA		Mouse	MGI:MGI:5619448|PMID:22864553
Biological Process	GO:0050729	positive regulation of inflammatory response	Ctss	IGI	MGI:MGI:2676278	Mouse	PMID:12163455
Biological Process	GO:0016485	protein processing	CTSS	IDA		Human	PMID:22864553
Biological Process	GO:0006508	proteolysis	CTSS	IDA		Human	PMID:12788072
Biological Process	GO:0006508	proteolysis	CTSS	IDA		Human	PMID:22864553
Biological Process	GO:0006508	proteolysis	Ctss	IDA		Mouse	PMID:11854359
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	CTSS	IDA		Human	PMID:22952693
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	Ctss	IMP		Mouse	MGI:MGI:5553237|PMID:22952693
Biological Process	GO:0051930	regulation of sensory perception of pain	Ctss	IMP		Rat	PMID:17551020|RGD:5686911
Biological Process	GO:0010447	response to acidic pH	CTSS	IDA		Human	PMID:22864553

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern