Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CTSZ
  • Mouse genes Ctsz
  • Rat genes Ctsz
  • Zfish genes ctsz
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ctsz

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004180	carboxypeptidase activity	CTSZ	IMP		Human	PMID:19433310
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:P26371	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:O15162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:P26371	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:Q5JR59	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:Q9UJV3-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:P26371	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:Q7Z3S9	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:O75031	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:P26371	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:P60014	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:Q07627	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:Q5TD97	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:Q63HR2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:Q8N9N5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:Q92764	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:Q9BYR6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:Q9BYR9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:Q9BYV9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTSZ	IPI	UniProtKB:Q9UJV3-2	Human	PMID:32296183
Cellular Component	GO:0005938	cell cortex	CTSZ	IDA		Human	PMID:19433310
Cellular Component	GO:0005938	cell cortex	Ctsz	IDA		Rat	PMID:19433310|RGD:12792998
Cellular Component	GO:0009986	cell surface	Ctsz	IDA		Rat	PMID:19433310|RGD:12792998
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSZ	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSZ	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Ctsz	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0031410	cytoplasmic vesicle	CTSZ	IDA		Human	PMID:19433310
Cellular Component	GO:0005783	endoplasmic reticulum	CTSZ	IDA		Human	GO_REF:0000054
Cellular Component	GO:0070062	extracellular exosome	CTSZ	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	CTSZ	IDA		Human	PMID:19433310
Cellular Component	GO:0005615	extracellular space	CTSZ	HDA		Human	PMID:20551380
Cellular Component	GO:0005615	extracellular space	Ctsz	IDA		Rat	PMID:19433310|RGD:12792998
Cellular Component	GO:0030426	growth cone	Ctsz	IDA		Rat	PMID:19433310|RGD:12792998
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CTSZ	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005764	lysosome	CTSZ	IDA		Human	PMID:19433310
Biological Process	GO:0001525	angiogenesis	ctsz	IMP	ZFIN:ZDB-MRPHLNO-090617-4	Zfish	PMID:19389629
Biological Process	GO:0001525	angiogenesis	ctsz	IMP	ZFIN:ZDB-MRPHLNO-090617-3,ZFIN:ZDB-MRPHLNO-090617-4	Zfish	PMID:19389629
Biological Process	GO:0001525	angiogenesis	ctsz	IMP	ZFIN:ZDB-MRPHLNO-090617-3	Zfish	PMID:19389629
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis	Ctsz	IEP		Mouse	MGI:MGI:3722010|PMID:17500053
Biological Process	GO:0010977	negative regulation of neuron projection development	Ctsz	IMP		Rat	PMID:19433310|RGD:12792998
Biological Process	GO:0010757	negative regulation of plasminogen activation	CTSZ	IMP		Human	PMID:19433310
Biological Process	GO:0032091	negative regulation of protein binding	CTSZ	IDA		Human	PMID:19433310
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	Ctsz	IMP		Rat	PMID:19433310|RGD:12792998
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Ctsz	IMP		Rat	PMID:19433310|RGD:12792998
Biological Process	GO:0006508	proteolysis	CTSZ	IMP		Human	PMID:19433310
Biological Process	GO:1901214	regulation of neuron death	CTSZ	IGI	UniProtKB:P07323	Human	PMID:19433310

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern