Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CUBN
  • Mouse genes Cubn
  • Rat genes Cubn
  • Zfish genes cubn
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cubn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0038024	cargo receptor activity	CUBN	EXP		Human	PMID:14576052
Molecular Function	GO:0038024	cargo receptor activity	CUBN	IDA		Human	PMID:14576052
Molecular Function	GO:0038024	cargo receptor activity	CUBN	EXP		Human	PMID:20237569
Molecular Function	GO:0038024	cargo receptor activity	CUBN	EXP		Human	PMID:30523278
Molecular Function	GO:0038024	cargo receptor activity	Cubn	IMP		Rat	PMID:14576052|RGD:8554807
Molecular Function	GO:0030492	hemoglobin binding	Cubn	IDA		Rat	PMID:11805171|RGD:2317837
Molecular Function	GO:0042802	identical protein binding	Cubn	IPI	RGD:68355	Rat	PMID:11595644|RGD:628443
Molecular Function	GO:0042802	identical protein binding	Cubn	IPI	UniProtKB:O70244	Rat	PMID:20237569|RGD:8554548
Molecular Function	GO:0005515	protein binding	CUBN	IPI	UniProtKB:Q9BXJ7	Human	PMID:14576052
Molecular Function	GO:0005515	protein binding	CUBN	IPI	UniProtKB:P27352	Human	PMID:20237569
Molecular Function	GO:0005515	protein binding	CUBN	IPI	UniProtKB:Q9BXJ7	Human	PMID:30523278
Molecular Function	GO:0005515	protein binding	Cubn	IPI	PR:P16110	Mouse	PMID:11856751
Molecular Function	GO:0005515	protein binding	Cubn	IPI	UniProtKB:Q9QZ76	Rat	PMID:12724130|RGD:1299150
Molecular Function	GO:0042803	protein homodimerization activity	CUBN	IDA		Human	PMID:10552972
Molecular Function	GO:0038023	signaling receptor activity	Cubn	IDA		Rat	PMID:11581259|RGD:70244
Cellular Component	GO:0045177	apical part of cell	Cubn	IDA		Mouse	PMID:15342463
Cellular Component	GO:0045177	apical part of cell	Cubn	IDA		Mouse	PMID:11856751
Cellular Component	GO:0045177	apical part of cell	Cubn	IDA		Mouse	PMID:15616221
Cellular Component	GO:0016324	apical plasma membrane	CUBN	IDA		Human	PMID:14576052
Cellular Component	GO:0016324	apical plasma membrane	Cubn	IDA		Mouse	PMID:15616221
Cellular Component	GO:0016324	apical plasma membrane	Cubn	IDA		Rat	PMID:19202329|RGD:13210544
Cellular Component	GO:0005903	brush border	Cubn	IDA		Mouse	PMID:12815097
Cellular Component	GO:0031526	brush border membrane	Cubn	IDA		Rat	PMID:12724130|RGD:1299150
Cellular Component	GO:0031526	brush border membrane	Cubn	IDA		Rat	PMID:17990981|RGD:2317831
Cellular Component	GO:0005905	clathrin-coated pit	Cubn	IDA		Mouse	PMID:15616221
Cellular Component	GO:0005905	clathrin-coated pit	Cubn	IDA		Rat	PMID:14576052|RGD:8554807
Cellular Component	GO:0030135	coated vesicle	Cubn	IDA		Rat	PMID:14576052|RGD:8554807
Cellular Component	GO:0005737	cytoplasm	Cubn	IDA		Mouse	PMID:11856751
Cellular Component	GO:0030139	endocytic vesicle	CUBN	IDA		Human	PMID:14576052
Cellular Component	GO:0030139	endocytic vesicle	Cubn	IDA		Mouse	PMID:15616221
Cellular Component	GO:0030666	endocytic vesicle membrane	Cubn	IDA		Rat	PMID:15578272|RGD:2317835
Cellular Component	GO:0005783	endoplasmic reticulum	Cubn	IDA		Mouse	PMID:15616221
Cellular Component	GO:0005768	endosome	Cubn	IDA		Mouse	PMID:10766831
Cellular Component	GO:0005768	endosome	Cubn	IDA		Mouse	PMID:12815097
Cellular Component	GO:0070062	extracellular exosome	CUBN	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CUBN	IDA		Human	PMID:21082674
Cellular Component	GO:0070062	extracellular exosome	CUBN	HDA		Human	PMID:23533145
Cellular Component	GO:0005794	Golgi apparatus	Cubn	IDA		Mouse	PMID:15616221
Cellular Component	GO:0005798	Golgi-associated vesicle	Cubn	IDA		Rat	PMID:14576052|RGD:8554807
Cellular Component	GO:0043202	lysosomal lumen	Cubn	IDA		Rat	PMID:15578272|RGD:2317835
Cellular Component	GO:0016020	membrane	CUBN	IDA		Human	PMID:14576052
Cellular Component	GO:0016020	membrane	Cubn	IDA		Rat	PMID:11595644|RGD:628443
Cellular Component	GO:0031528	microvillus membrane	CUBN	IDA		Human	PMID:14576052
Cellular Component	GO:0031528	microvillus membrane	Cubn	IDA		Mouse	PMID:14321840
Cellular Component	GO:0005886	plasma membrane	Cubn	IDA		Rat	PMID:14576052|RGD:8554807
Cellular Component	GO:0032991	protein-containing complex	Cubn	IDA		Rat	PMID:17990981|RGD:2317831
Cellular Component	GO:0043235	receptor complex	CUBN	IPI		Human	PMID:30523278
Cellular Component	GO:0043235	receptor complex	Cubn	IDA		Rat	PMID:19202329|RGD:13210544
Biological Process	GO:0042366	cobalamin catabolic process	Cubn	IMP		Rat	PMID:14576052|RGD:8554807
Biological Process	GO:0009235	cobalamin metabolic process	CUBN	IDA		Human	PMID:14576052
Biological Process	GO:0015889	cobalamin transport	CUBN	IDA		Human	PMID:14576052
Biological Process	GO:0015889	cobalamin transport	Cubn	IMP		Rat	PMID:14576052|RGD:8554807
Biological Process	GO:0020028	endocytic hemoglobin import into cell	Cubn	IMP		Rat	PMID:11805171|RGD:2317837
Biological Process	GO:0051649	establishment of localization in cell	Cubn	IDA		Mouse	PMID:15616221
Biological Process	GO:0051649	establishment of localization in cell	Cubn	IMP		Mouse	PMID:15616221
Biological Process	GO:0001701	in utero embryonic development	Cubn	IDA		Rat	PMID:15616221|RGD:1599657
Biological Process	GO:0042953	lipoprotein transport	Cubn	IDA		Mouse	PMID:15616221
Biological Process	GO:0006898	receptor-mediated endocytosis	Cubn	IMP		Mouse	PMID:15616221
Biological Process	GO:0006898	receptor-mediated endocytosis	Cubn	IDA		Rat	PMID:11595644|RGD:628443
Biological Process	GO:0006898	receptor-mediated endocytosis	Cubn	IMP		Rat	PMID:14576052|RGD:8554807
Biological Process	GO:0009617	response to bacterium	Cubn	IEP		Mouse	PMID:23012479
Biological Process	GO:0007584	response to nutrient	Cubn	IMP		Rat	PMID:15616221|RGD:1599657

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern