Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CUL1
  • Mouse genes Cul1
  • Rat genes Cul1
  • Zfish genes cul1a,cul1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cul1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P46527	Human	PMID:11961546
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P62877	Human	PMID:11961546
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q86VP6	Human	PMID:12504025
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P62877	Human	PMID:12504026
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P63208	Human	PMID:12504026
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q13309	Human	PMID:12504026
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q86VP6	Human	PMID:12504026
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P62877	Human	PMID:12609982
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P63208	Human	PMID:12609982
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q13309	Human	PMID:12609982
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q86VP6	Human	PMID:12609982
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9Y297	Human	PMID:12609982
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P63208	Human	PMID:14685242
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q86VP6	Human	PMID:15537541
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q83730	Human	PMID:16051867
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9UKT5	Human	PMID:16278047
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P67809	Human	PMID:16797541
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q7Z6M2	Human	PMID:16797541
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q86VP6	Human	PMID:16861300
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P19474	Human	PMID:16880511
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P63208	Human	PMID:17290223
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q86VP6	Human	PMID:17290223
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q15843	Human	PMID:17318178
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9Y297	Human	PMID:17318178
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P61081	Human	PMID:17914462
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q8NI29	Human	PMID:18203720
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q96EF6	Human	PMID:18203720
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9H4M3	Human	PMID:18203720
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q13309	Human	PMID:18239684
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q15843	Human	PMID:18264111
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q15843	Human	PMID:18274552
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9UKB1	Human	PMID:18354482
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9Y297	Human	PMID:18354482
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:O96017	Human	PMID:18644861
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q6TVW2	Human	PMID:18667692
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q15843	Human	PMID:18723677
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:O94888	Human	PMID:18775313
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P46527	Human	PMID:18805092
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P61081	Human	PMID:18805092
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P62877	Human	PMID:18805092
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q15843	Human	PMID:18805092
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P63208	Human	PMID:18818696
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q96GG9	Human	PMID:18826954
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P63208	Human	PMID:18929646
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9UKB1	Human	PMID:19615732
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9Y297	Human	PMID:19615732
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q15843	Human	PMID:19713960
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P49427	Human	PMID:19945379
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P63208	Human	PMID:19945379
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9Y297	Human	PMID:19945379
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P62877	Human	PMID:20399188
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P41002	Human	PMID:20596027
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q00987	Human	PMID:20708156
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q15843	Human	PMID:21102408
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q96Q27	Human	PMID:21119685
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P08238	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P63208	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P67809	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q13309	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q15843	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q7Z6M2	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q86VP6	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q8NEZ5	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q969H0	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q96EF6	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9UK99	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9UKB1	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9UKT8	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9Y297	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9Y4X5	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P52491	Human	PMID:21765416
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P62877	Human	PMID:21765416
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q15843	Human	PMID:21765416
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q8N668	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9NX08	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9P000	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:O94888	Human	PMID:22466964
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:O75586	Human	PMID:22479149
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P41002	Human	PMID:22632967
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P62877	Human	PMID:22660580
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P63208	Human	PMID:22660580
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q969H0	Human	PMID:23108047
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9NRD1	Human	PMID:23108047
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9UKT5	Human	PMID:23108047
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9UKT8	Human	PMID:23108047
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q8BFZ4	Human	PMID:23452855
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q8C4V4	Human	PMID:23452855
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q8BFZ4	Human	PMID:23452856
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q8C4V4	Human	PMID:23452856
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:O60826	Human	PMID:23563313
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q8WXC6-2	Human	PMID:23776465
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9Y4X5	Human	PMID:24076655
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q96GG9	Human	PMID:24192928
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9BTE7	Human	PMID:24192928
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q8ND76	Human	PMID:24794231
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P61081	Human	PMID:24949976
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P62877	Human	PMID:24949976
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q15843	Human	PMID:24949976
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9UKB1	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q86VP6	Human	PMID:25435324
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P41002	Human	PMID:25557911
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9UKB1	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q6PH85	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q8IWE4	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q92564	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q96GG9	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9BTE7	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q13309|UniProtKB:Q8IWE4	Human	PMID:27542266
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P63208	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P63208,UniProtKB:Q969H0-1	Human	PMID:28007894
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q13309	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q969H0	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q96EF6	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9NRD1	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9UKT5	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9Y4X5	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P62877,UniProtKB:P63208,UniProtKB:Q04721,UniProtKB:Q969H0	Human	PMID:29149593
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q9NRD1	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:P62877	Human	PMID:32726803
Molecular Function	GO:0005515	protein binding	CUL1	IPI	UniProtKB:Q15843	Human	PMID:32726803
Molecular Function	GO:0005515	protein binding	Cul1	IPI	UniProtKB:O94888|UniProtKB:P55072	Mouse	MGI:MGI:5915908|PMID:22466964
Molecular Function	GO:0005515	protein binding	Cul1	IPI	PR:P62878	Mouse	PMID:16880526
Molecular Function	GO:0005515	protein binding	Cul1	IPI	PR:Q9QZN0	Mouse	PMID:12665572
Molecular Function	GO:0005515	protein binding	Cul1	IPI	PR:Q9WTX5	Mouse	PMID:16880526
Molecular Function	GO:0005515	protein binding	Cul1	IPI	PR:Q9Z0Z3	Mouse	PMID:19398581
Molecular Function	GO:0005515	protein binding	Cul1	IPI	PR:Q60584	Mouse	PMID:19398581
Molecular Function	GO:0160072	ubiquitin ligase complex scaffold activity	CUL1	IDA		Human	PMID:15145941
Molecular Function	GO:0160072	ubiquitin ligase complex scaffold activity	CUL1	IDA		Human	PMID:23263282
Cellular Component	GO:0031461	cullin-RING ubiquitin ligase complex	CUL1	IDA		Human	PMID:22405651
Cellular Component	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex	CUL1	IPI	UniProtKB:O60260	Human	PMID:12628165
Cellular Component	GO:0005886	plasma membrane	CUL1	IDA		Human	PMID:19617556
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	CUL1	IDA		Human	PMID:11956208
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	CUL1	IDA		Human	PMID:15103331
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	CUL1	IDA		Human	PMID:15145941
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	CUL1	IDA		Human	PMID:16880511
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	CUL1	IDA		Human	PMID:20596027
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	CUL1	IDA		Human	PMID:21572392
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	CUL1	IDA		Human	PMID:21725316
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	CUL1	IDA		Human	PMID:23263282
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	CUL1	IDA		Human	PMID:25585578
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	CUL1	IDA		Human	PMID:28007894
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	Cul1	IDA		Mouse	MGI:MGI:4821082|PMID:12140560
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	Cul1	IDA		Mouse	MGI:MGI:5487698|PMID:23452856
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	Cul1	IDA		Mouse	PMID:12665572
Biological Process	GO:0009887	animal organ morphogenesis	Cul1	IMP	MGI:MGI:2152042	Mouse	PMID:10508527
Biological Process	GO:0006915	apoptotic process	Cul1	IMP	MGI:MGI:2152042	Mouse	PMID:10508527
Biological Process	GO:0008283	cell population proliferation	Cul1	IMP	MGI:MGI:2152042	Mouse	PMID:10508527
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	CUL1	IDA		Human	PMID:15145941
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	CUL1	IDA		Human	PMID:34480022
Biological Process	GO:0070936	protein K48-linked ubiquitination	CUL1	IDA		Human	PMID:15145941
Biological Process	GO:0070936	protein K48-linked ubiquitination	CUL1	IDA		Human	PMID:23263282
Biological Process	GO:0070936	protein K48-linked ubiquitination	Cul1	IDA		Mouse	PMID:29593216
Biological Process	GO:0006513	protein monoubiquitination	Cul1	IGI	MGI:MGI:103575,MGI:MGI:1891829,MGI:MGI:1919429	Mouse	PMID:21343341
Biological Process	GO:0016567	protein ubiquitination	CUL1	IDA		Human	PMID:15103331
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	CUL1	IDA		Human	PMID:15103331
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Cul1	IDA		Mouse	MGI:MGI:4821082|PMID:12140560

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern