Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CUL2
  • Mouse genes Cul2
  • Rat genes Cul2
  • Zfish genes cul2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cul2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q86VP6	Human	PMID:12504026
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q86VP6	Human	PMID:12609982
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P40337	Human	PMID:15601820
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P62877	Human	PMID:15601820
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q15369	Human	PMID:15601820
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P62877	Human	PMID:17183367
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q15369	Human	PMID:17183367
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q8N668	Human	PMID:17183367
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q9C0D3	Human	PMID:17304241
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P40337	Human	PMID:18323857
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:O94888	Human	PMID:18775313
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q96GG9	Human	PMID:18826954
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P62877	Human	PMID:19327355
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q15369	Human	PMID:19327355
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:O94888	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P08238	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P40337	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q15048	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q15369	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q9BQ90	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q9C0D3	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q8N668	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q9GZQ3	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q9H0A8	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q9NX08	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q9Y6G5	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P12504	Human	PMID:22190034
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:O94888	Human	PMID:22466964
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P40337,UniProtKB:P62877	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P40337,UniProtKB:P62877,UniProtKB:Q15370,UniProtKB:Q16665	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P40337,UniProtKB:P62877,UniProtKB:Q16665	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P40337,UniProtKB:P62877,UniProtKB:Q16665,UniProtKB:Q16665	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P40337,UniProtKB:P62877,UniProtKB:Q99814	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P40337,UniProtKB:Q16665,UniProtKB:Q96GG9	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P62877	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q96GG9	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q15369	Human	PMID:23563313
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q8N668	Human	PMID:23563313
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q96GG9	Human	PMID:24192928
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q9BTE7	Human	PMID:24192928
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P12504	Human	PMID:24402281
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P40337	Human	PMID:25661653
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q6PH85	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q8IWE4	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q92564	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q96GG9	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q9BTE7	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:Q9BQ90	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CUL2	IPI	UniProtKB:P62877	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Cul2	IPI	PR:P40338	Mouse	PMID:15601820
Molecular Function	GO:0005515	protein binding	Cul2	IPI	PR:P42859	Mouse	PMID:17500595
Molecular Function	GO:0005515	protein binding	Cul2	IPI	RGD:61928	Rat	PMID:19950214|RGD:2317359
Molecular Function	GO:0044877	protein-containing complex binding	Cul2	IPI	RGD:3960|RGD:1308453|RGD:620658|RGD:621200	Rat	PMID:10213691|RGD:2301042
Molecular Function	GO:0031625	ubiquitin protein ligase binding	CUL2	IDA		Human	PMID:17636018
Cellular Component	GO:0031462	Cul2-RING ubiquitin ligase complex	CUL2	IDA		Human	PMID:17636018
Cellular Component	GO:0031462	Cul2-RING ubiquitin ligase complex	Cul2	IDA		Mouse	PMID:16129783
Cellular Component	GO:0005730	nucleolus	Cul2	IDA		Mouse	PMID:16129783
Cellular Component	GO:0005654	nucleoplasm	CUL2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030891	VCB complex	Cul2	IDA		Rat	PMID:10213691|RGD:2301042
Biological Process	GO:0043009	chordate embryonic development	cul2	IMP	ZFIN:ZDB-MRPHLNO-080826-1	Zfish	PMID:18372249
Biological Process	GO:0030163	protein catabolic process	Cul2	IMP		Mouse	PMID:15601820
Biological Process	GO:0001944	vasculature development	cul2	IMP	ZFIN:ZDB-MRPHLNO-080826-1	Zfish	PMID:18372249

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern