Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CUL4A
  • Mouse genes Cul4a
  • Rat genes Cul4a
  • Zfish genes cul4a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cul4a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q86VP6	Human	PMID:12504025
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q86VP6	Human	PMID:12504026
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q86VP6	Human	PMID:12609982
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q16531	Human	PMID:14739464
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q16531	Human	PMID:16473935
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q92466	Human	PMID:16473935
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q13216,UniProtKB:Q16531	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q13620,UniProtKB:Q16531,UniProtKB:Q58WW2	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q13620,UniProtKB:Q16531,UniProtKB:Q5H9S7	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q13620,UniProtKB:Q16531,UniProtKB:Q5TAQ9	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q13620,UniProtKB:Q16531,UniProtKB:Q8TEB1	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q13620,UniProtKB:Q16531,UniProtKB:Q92466	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q13620,UniProtKB:Q16531,UniProtKB:Q9BW61	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q13620,UniProtKB:Q16531,UniProtKB:Q9Y4B6	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q16531,UniProtKB:Q66K64	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q16531,UniProtKB:Q7L5Y6	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q16531,UniProtKB:Q96JK2	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q16531,UniProtKB:Q9NXF7	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q16531,UniProtKB:Q9NZJ0	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q8N5D0	Human	PMID:16964240
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q15291	Human	PMID:17041588
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q16531	Human	PMID:17041588
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q92466	Human	PMID:17041588
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:O94888	Human	PMID:18775313
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q16531	Human	PMID:19966799
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q16531	Human	PMID:21113133
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:P08238	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q16531	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q86VP6	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q92466	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q7Z4G1	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q8N668	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q9GZQ3	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q9H0A8	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q9NX08	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q9UBI1	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q16531	Human	PMID:22157821
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:O94888	Human	PMID:22466964
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:P55072	Human	PMID:22466964
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q92466	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q6PH85	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q8IWE4	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q96GG9	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q9BTE7	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q92466	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q16531	Human	PMID:30945288
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:Q92466	Human	PMID:30945288
Molecular Function	GO:0005515	protein binding	CUL4A	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Cul4a	IPI	UniProtKB:P48432	Mouse	MGI:MGI:7387162|PMID:30442713
Molecular Function	GO:0005515	protein binding	Cul4a	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0005515	protein binding	Cul4a	IPI	PR:P46414	Mouse	PMID:16467204
Molecular Function	GO:0061630	ubiquitin protein ligase activity	CUL4A	IDA		Human	PMID:20870715
Molecular Function	GO:0031625	ubiquitin protein ligase binding	CUL4A	IDA		Human	PMID:11027288
Molecular Function	GO:0031625	ubiquitin protein ligase binding	CUL4A	IDA		Human	PMID:20870715
Cellular Component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	CUL4A	IDA		Human	PMID:16949367
Cellular Component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	CUL4A	IDA		Human	PMID:18381890
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	CUL4A	EXP		Human	PMID:22118460
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	CUL4A	IDA		Human	PMID:12732143
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	CUL4A	IDA		Human	PMID:14739464
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	CUL4A	IDA		Human	PMID:17085480
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	CUL4A	IDA		Human	PMID:18794347
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	CUL4A	IDA		Human	PMID:20129063
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	CUL4A	IDA		Human	PMID:20223979
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	Cul4a	EXP		Mouse	MGI:MGI:6867266|PMID:22118460
Cellular Component	GO:0005634	nucleus	CUL4A	IDA		Human	PMID:10585395
Cellular Component	GO:0005634	nucleus	CUL4A	IDA		Human	PMID:11027288
Biological Process	GO:0008283	cell population proliferation	Cul4a	IDA		Mouse	PMID:16467204
Biological Process	GO:0034644	cellular response to UV	CUL4A	EXP		Human	PMID:22118460
Biological Process	GO:0034644	cellular response to UV	Cul4a	EXP		Mouse	MGI:MGI:6867266|PMID:22118460
Biological Process	GO:0006974	DNA damage response	CUL4A	EXP		Human	PMID:22118460
Biological Process	GO:0006974	DNA damage response	Cul4a	EXP		Mouse	MGI:MGI:6867266|PMID:22118460
Biological Process	GO:0035118	embryonic pectoral fin morphogenesis	cul4a	IMP	ZFIN:ZDB-MRPHLNO-100503-4	Zfish	PMID:20223979
Biological Process	GO:0048821	erythrocyte development	cul4a	IMP	ZFIN:ZDB-FISH-220331-9	Zfish	PMID:31101894
Biological Process	GO:0007507	heart development	cul4a	IMP	ZFIN:ZDB-MRPHLNO-150402-10	Zfish	PMID:25274780
Biological Process	GO:0030097	hemopoiesis	Cul4a	IMP	MGI:MGI:3805522	Mouse	PMID:18339895
Biological Process	GO:0001701	in utero embryonic development	Cul4a	IMP		Mouse	MGI:MGI:2183132|PMID:12077329
Biological Process	GO:0030853	negative regulation of granulocyte differentiation	Cul4a	IDA		Mouse	PMID:12393421
Biological Process	GO:0071600	otic vesicle morphogenesis	cul4a	IMP	ZFIN:ZDB-MRPHLNO-100503-4	Zfish	PMID:20223979
Biological Process	GO:0033339	pectoral fin development	cul4a	IMP	ZFIN:ZDB-MRPHLNO-150402-10	Zfish	PMID:25274780
Biological Process	GO:0008284	positive regulation of cell population proliferation	Cul4a	IDA		Mouse	PMID:16467204
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	Cul4a	IMP		Mouse	PMID:19056892
Biological Process	GO:0045732	positive regulation of protein catabolic process	CUL4A	IDA		Human	PMID:11027288
Biological Process	GO:0045732	positive regulation of protein catabolic process	CUL4A	IDA		Human	PMID:20870715
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	CUL4A	IMP		Human	PMID:14739464
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Cul4a	IDA		Mouse	PMID:16467204
Biological Process	GO:0016567	protein ubiquitination	CUL4A	IDA		Human	PMID:26431207
Biological Process	GO:0016567	protein ubiquitination	CUL4A	IMP		Human	PMID:28437394
Biological Process	GO:2000001	regulation of DNA damage checkpoint	Cul4a	IMP	MGI:MGI:3851025	Mouse	PMID:19481525
Biological Process	GO:2000819	regulation of nucleotide-excision repair	Cul4a	IMP	MGI:MGI:3851025	Mouse	PMID:19481525
Biological Process	GO:0051246	regulation of protein metabolic process	Cul4a	IMP		Mouse	PMID:19056892
Biological Process	GO:0042254	ribosome biogenesis	CUL4A	IMP		Human	PMID:26711351
Biological Process	GO:0042254	ribosome biogenesis	Cul4a	IMP		Mouse	MGI:MGI:6294197|PMID:26711351
Biological Process	GO:0035019	somatic stem cell population maintenance	Cul4a	IMP	MGI:MGI:2183544	Mouse	PMID:17616641
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Cul4a	IMP	MGI:MGI:3851025	Mouse	PMID:19481525

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern