Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CUL4B
  • Mouse genes Cul4b
  • Rat genes Cul4b
  • Zfish genes cul4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cul4b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003684	damaged DNA binding	CUL4B	IDA		Human	PMID:22334663
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:P62877	Human	PMID:12609982
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q86VP6	Human	PMID:12609982
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q13619,UniProtKB:Q16531,UniProtKB:Q58WW2	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q13619,UniProtKB:Q16531,UniProtKB:Q5H9S7	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q13619,UniProtKB:Q16531,UniProtKB:Q5TAQ9	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q13619,UniProtKB:Q16531,UniProtKB:Q8TEB1	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q13619,UniProtKB:Q16531,UniProtKB:Q92466	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q13619,UniProtKB:Q16531,UniProtKB:Q9BW61	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q13619,UniProtKB:Q16531,UniProtKB:Q9Y4B6	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q8N5D0	Human	PMID:16964240
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q16531	Human	PMID:17041588
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q9BQ67	Human	PMID:17041588
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:O94888	Human	PMID:18775313
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q16531	Human	PMID:19651607
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:P08238	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q16531	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q86VP6	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q93009	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q86X83	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q8N668	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q9GZQ3	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q9NX08	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q9UBI1	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q9Y6G5	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:O94888	Human	PMID:22466964
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q16543	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:P62877	Human	PMID:23238014
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q16531	Human	PMID:23238014
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q16543	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q86VP6	Human	PMID:25435324
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q9H898-2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:P62877	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q16531	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q86VP6	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q6PH85	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q8IWE4	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q96GG9	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q9BTE7	Human	PMID:26906416
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:P62877	Human	PMID:30945288
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q16531	Human	PMID:30945288
Molecular Function	GO:0005515	protein binding	CUL4B	IPI	UniProtKB:Q93009	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Cul4b	IPI	UniProtKB:P48432	Mouse	MGI:MGI:7387162|PMID:30442713
Molecular Function	GO:0005515	protein binding	Cul4b	IPI	RGD:1305159	Rat	PMID:21816345|RGD:9587469
Cellular Component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	CUL4B	IDA		Human	PMID:16949367
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	CUL4B	EXP		Human	PMID:22118460
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	Cul4b	EXP		Mouse	MGI:MGI:6867266|PMID:22118460
Cellular Component	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	CUL4B	IDA		Human	PMID:18794347
Cellular Component	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	CUL4B	IDA		Human	PMID:21628527
Cellular Component	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	CUL4B	IDA		Human	PMID:22334663
Cellular Component	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	Cul4b	IDA		Mouse	MGI:MGI:7334688|PMID:35197566
Cellular Component	GO:0005829	cytosol	CUL4B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Cul4b	IDA		Rat	PMID:21816345|RGD:9587469
Cellular Component	GO:0070062	extracellular exosome	CUL4B	HDA		Human	PMID:19056867
Cellular Component	GO:0005654	nucleoplasm	CUL4B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Cul4b	IDA		Rat	PMID:21816345|RGD:9587469
Biological Process	GO:0048708	astrocyte differentiation	Cul4b	IMP	MGI:MGI:5500946	Mouse	PMID:26025376
Biological Process	GO:0010467	gene expression	Cul4b	IMP	MGI:MGI:5500946	Mouse	PMID:26025376
Biological Process	GO:0035518	histone H2A monoubiquitination	CUL4B	IDA		Human	PMID:22334663
Biological Process	GO:0031175	neuron projection development	Cul4b	IDA		Rat	PMID:21816345|RGD:9587469
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	Cul4b	IMP		Mouse	PMID:19056892
Biological Process	GO:0045732	positive regulation of protein catabolic process	Cul4b	IMP		Mouse	PMID:18602923
Biological Process	GO:0010498	proteasomal protein catabolic process	CUL4B	IDA		Human	PMID:25970626
Biological Process	GO:0010498	proteasomal protein catabolic process	CUL4B	IMP		Human	PMID:25970626
Biological Process	GO:0000209	protein polyubiquitination	Cul4b	IDA		Mouse	MGI:MGI:7334688|PMID:35197566
Biological Process	GO:0016567	protein ubiquitination	CUL4B	IMP		Human	PMID:28437394
Biological Process	GO:0042254	ribosome biogenesis	CUL4B	IMP		Human	PMID:26711351
Biological Process	GO:0042254	ribosome biogenesis	Cul4b	IMP		Mouse	MGI:MGI:6294197|PMID:26711351
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Cul4b	IDA		Mouse	MGI:MGI:7334688|PMID:35197566
Biological Process	GO:0070914	UV-damage excision repair	CUL4B	IDA		Human	PMID:22334663

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern