Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CUX2
  • Mouse genes Cux2
  • Rat genes Cux2
  • Zfish genes cux2a,cux2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cux2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Cux2	IDA		Mouse	PMID:15656993
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Cux2	IDA		Mouse	MGI:MGI:3531237|PMID:15656993
Molecular Function	GO:0005515	protein binding	CUX2	IPI	UniProtKB:Q93009	Human	PMID:35044719
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Cux2	IDA		Mouse	MGI:MGI:3531237|PMID:15656993
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Cux2	IMP		Mouse	MGI:MGI:4836115|PMID:20510857
Molecular Function	GO:0043565	sequence-specific DNA binding	CUX2	IDA		Human	PMID:15656993
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	CUX2	IDA		Human	PMID:28473536
Cellular Component	GO:0070062	extracellular exosome	CUX2	HDA		Human	PMID:19056867
Cellular Component	GO:0005634	nucleus	CUX2	IDA		Human	PMID:15656993
Cellular Component	GO:0005634	nucleus	Cux2	IDA		Mouse	PMID:17412818
Cellular Component	GO:0005634	nucleus	Cux2	IDA		Mouse	PMID:15656993
Biological Process	GO:0071310	cellular response to organic substance	Cux2	IDA		Mouse	PMID:18794345
Biological Process	GO:0050890	cognition	CUX2	IMP		Human	PMID:15389760
Biological Process	GO:0021782	glial cell development	cux2b	IMP	ZFIN:ZDB-CRISPR-191009-29,ZFIN:ZDB-CRISPR-191009-30	Zfish	PMID:30924555
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Cux2	IDA		Mouse	PMID:15656993
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	CUX2	IDA		Human	PMID:15656993
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Cux2	IDA		Mouse	MGI:MGI:3531237|PMID:15656993
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	Cux2	IMP		Mouse	MGI:MGI:4836115|PMID:20510857
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	Cux2	IMP		Mouse	MGI:MGI:4836115|PMID:20510857
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Cux2	IMP		Mouse	MGI:MGI:4836115|PMID:20510857
Biological Process	GO:0010628	positive regulation of gene expression	Cux2	IMP		Mouse	MGI:MGI:4836115|PMID:20510857
Biological Process	GO:0051965	positive regulation of synapse assembly	Cux2	IMP		Mouse	MGI:MGI:4836115|PMID:20510857
Biological Process	GO:0060041	retina development in camera-type eye	cux2b	IMP	ZFIN:ZDB-CRISPR-191009-29,ZFIN:ZDB-CRISPR-191009-30	Zfish	PMID:30924555
Biological Process	GO:0007614	short-term memory	Cux2	IMP		Mouse	MGI:MGI:4836115|PMID:20510857

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern