Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CX3CL1
  • Mouse genes Cx3cl1
  • Rat genes Cx3cl1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cx3cl1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042056	chemoattractant activity	CX3CL1	IMP		Human	PMID:10899174
Molecular Function	GO:0008009	chemokine activity	CX3CL1	IGI	UniProtKB:P35411	Human	PMID:10415068
Molecular Function	GO:0008009	chemokine activity	CX3CL1	IDA		Human	PMID:21829356
Molecular Function	GO:0008009	chemokine activity	Cx3cl1	IDA		Rat	PMID:9724801|RGD:727628
Molecular Function	GO:0031737	CX3C chemokine receptor binding	CX3CL1	IDA		Human	PMID:10415068
Molecular Function	GO:0031737	CX3C chemokine receptor binding	CX3CL1	IDA		Human	PMID:23125415
Molecular Function	GO:0031737	CX3C chemokine receptor binding	Cx3cl1	IDA		Mouse	MGI:MGI:3833195|PMID:18971423
Molecular Function	GO:0045237	CXCR1 chemokine receptor binding	CX3CL1	IPI	UniProtKB:Q9Z0D9	Human	PMID:10187784
Molecular Function	GO:0005178	integrin binding	CX3CL1	IDA		Human	PMID:23125415
Molecular Function	GO:0005515	protein binding	CX3CL1	IPI	UniProtKB:P05106	Human	PMID:23125415
Molecular Function	GO:0005515	protein binding	CX3CL1	IPI	UniProtKB:P05106	Human	PMID:24789099
Molecular Function	GO:0005515	protein binding	CX3CL1	IPI	UniProtKB:P05556	Human	PMID:24789099
Molecular Function	GO:0005515	protein binding	CX3CL1	IPI	UniProtKB:P69332	Human	PMID:25745166
Molecular Function	GO:0005515	protein binding	CX3CL1	IPI	UniProtKB:Q8I2D9	Human	PMID:27653778
Molecular Function	GO:0005515	protein binding	CX3CL1	IPI	UniProtKB:Q8IEJ0	Human	PMID:27653778
Molecular Function	GO:0005515	protein binding	CX3CL1	IPI	UniProtKB:P49238	Human	PMID:9931005
Cellular Component	GO:0044297	cell body	Cx3cl1	IDA		Mouse	MGI:MGI:6189307|PMID:12815711
Cellular Component	GO:0042995	cell projection	Cx3cl1	IDA		Rat	PMID:11870871|RGD:4892001
Cellular Component	GO:0009986	cell surface	CX3CL1	IDA		Human	PMID:12714508
Cellular Component	GO:0005737	cytoplasm	Cx3cl1	IDA		Rat	PMID:19748551|RGD:4891944
Cellular Component	GO:0005576	extracellular region	CX3CL1	IDA		Human	PMID:10415068
Cellular Component	GO:0005576	extracellular region	CX3CL1	IMP		Human	PMID:10899174
Cellular Component	GO:0005576	extracellular region	CX3CL1	IDA		Human	PMID:12714508
Cellular Component	GO:0005576	extracellular region	Cx3cl1	IDA		Rat	PMID:16019082|RGD:13673766
Cellular Component	GO:0016020	membrane	CX3CL1	IDA		Human	PMID:10899174
Cellular Component	GO:0016020	membrane	CX3CL1	IDA		Human	PMID:12714508
Cellular Component	GO:0016020	membrane	Cx3cl1	IDA		Rat	PMID:16019082|RGD:13673766
Cellular Component	GO:0043005	neuron projection	Cx3cl1	IDA		Mouse	MGI:MGI:6189307|PMID:12815711
Cellular Component	GO:0043005	neuron projection	Cx3cl1	IDA		Rat	PMID:15341587|RGD:1358720
Cellular Component	GO:0043025	neuronal cell body	Cx3cl1	IDA		Mouse	MGI:MGI:6189307|PMID:12815711
Cellular Component	GO:0043025	neuronal cell body	Cx3cl1	IDA		Rat	PMID:12059974|RGD:13673875
Cellular Component	GO:0043025	neuronal cell body	Cx3cl1	IDA		Rat	PMID:15341587|RGD:1358720
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Cx3cl1	IDA		Rat	PMID:11870871|RGD:4892001
Cellular Component	GO:0005886	plasma membrane	Cx3cl1	IDA		Mouse	MGI:MGI:6258315|PMID:28612258
Biological Process	GO:0007568	aging	Cx3cl1	IEP		Rat	PMID:20018408|RGD:9491804
Biological Process	GO:0060055	angiogenesis involved in wound healing	Cx3cl1	IMP	MGI:MGI:3608773	Mouse	PMID:18097059
Biological Process	GO:0035425	autocrine signaling	Cx3cl1	IGI	UniProtKB:P35411	Rat	PMID:12729461|RGD:13673777
Biological Process	GO:0007155	cell adhesion	CX3CL1	IPI	UniProtKB:Q9Z0D9	Human	PMID:10187784
Biological Process	GO:0060326	cell chemotaxis	CX3CL1	IDA		Human	PMID:10415068
Biological Process	GO:0098609	cell-cell adhesion	Cx3cl1	IDA		Rat	PMID:12729461|RGD:13673777
Biological Process	GO:0070098	chemokine-mediated signaling pathway	CX3CL1	IDA		Human	PMID:10415068
Biological Process	GO:0006935	chemotaxis	CX3CL1	IDA		Human	PMID:21829356
Biological Process	GO:0006935	chemotaxis	CX3CL1	IMP		Human	PMID:23125415
Biological Process	GO:0006935	chemotaxis	Cx3cl1	IGI	UniProtKB:P49238	Rat	PMID:16019082|RGD:13673766
Biological Process	GO:0006935	chemotaxis	Cx3cl1	IDA		Rat	PMID:9724801|RGD:727628
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Cx3cl1	IMP		Mouse	PMID:18971423
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Cx3cl1	IDA		Mouse	PMID:18971423
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Cx3cl1	IDA		Mouse	PMID:18322241
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Cx3cl1	IGI	UniProtKB:P35411	Rat	PMID:12729461|RGD:13673777
Biological Process	GO:0060080	inhibitory postsynaptic potential	Cx3cl1	IMP		Rat	PMID:19748551|RGD:4891944
Biological Process	GO:0033622	integrin activation	CX3CL1	IMP		Human	PMID:23125415
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	CX3CL1	IMP		Human	PMID:23125415
Biological Process	GO:0048247	lymphocyte chemotaxis	Cx3cl1	IDA		Mouse	PMID:9177350
Biological Process	GO:0001774	microglial cell activation	Cx3cl1	IDA		Rat	PMID:11870871|RGD:4892001
Biological Process	GO:0001774	microglial cell activation	Cx3cl1	IDA		Rat	PMID:20018408|RGD:9491804
Biological Process	GO:0061518	microglial cell proliferation	CX3CL1	IMP		Human	PMID:12125082
Biological Process	GO:0043066	negative regulation of apoptotic process	CX3CL1	IMP		Human	PMID:24294368
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	CX3CL1	IGI	UniProtKB:P35411	Human	PMID:10869418
Biological Process	GO:0030336	negative regulation of cell migration	CX3CL1	IDA		Human	PMID:25435433
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Cx3cl1	IDA		Mouse	PMID:18971423
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Cx3cl1	IDA		Mouse	PMID:18322241
Biological Process	GO:1900450	negative regulation of glutamate receptor signaling pathway	Cx3cl1	IDA		Rat	PMID:16019082|RGD:13673766
Biological Process	GO:0110091	negative regulation of hippocampal neuron apoptotic process	CX3CL1	IGI	UniProtKB:P35411	Human	PMID:10869418
Biological Process	GO:0032690	negative regulation of interleukin-1 alpha production	Cx3cl1	IDA		Rat	PMID:19627440|RGD:13673772
Biological Process	GO:1903979	negative regulation of microglial cell activation	Cx3cl1	IDA		Rat	PMID:19627440|RGD:13673772
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	CX3CL1	IDA		Human	PMID:10652441
Biological Process	GO:0045906	negative regulation of vasoconstriction	Cx3cl1	IDA		Rat	PMID:19201996|RGD:4891967
Biological Process	GO:0070050	neuron cellular homeostasis	Cx3cl1	IDA		Rat	PMID:16019082|RGD:13673766
Biological Process	GO:0030593	neutrophil chemotaxis	Cx3cl1	IDA		Mouse	PMID:9177350
Biological Process	GO:0030168	platelet activation	Cx3cl1	IMP		Rat	PMID:12969973|RGD:4891996
Biological Process	GO:0050918	positive chemotaxis	CX3CL1	IMP		Human	PMID:10899174
Biological Process	GO:0032233	positive regulation of actin filament bundle assembly	CX3CL1	IGI	UniProtKB:P35411	Human	PMID:10415068
Biological Process	GO:0051041	positive regulation of calcium-independent cell-cell adhesion	CX3CL1	IDA		Human	PMID:12714508
Biological Process	GO:0045785	positive regulation of cell adhesion	Cx3cl1	IDA		Rat	PMID:17114429|RGD:4891970
Biological Process	GO:0030335	positive regulation of cell migration	Cx3cl1	IDA		Rat	PMID:17114429|RGD:4891970
Biological Process	GO:0008284	positive regulation of cell population proliferation	CX3CL1	IMP		Human	PMID:24294368
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Cx3cl1	IGI	UniProtKB:P49797	Rat	PMID:12729461|RGD:13673777
Biological Process	GO:1903721	positive regulation of I-kappaB phosphorylation	CX3CL1	IGI	UniProtKB:P35411	Human	PMID:10869418
Biological Process	GO:0050729	positive regulation of inflammatory response	CX3CL1	IEP		Human	PMID:11777952
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	Cx3cl1	IMP		Rat	PMID:19282612|RGD:4891965
Biological Process	GO:0043410	positive regulation of MAPK cascade	CX3CL1	IGI	UniProtKB:Q01986	Human	PMID:10415068
Biological Process	GO:1904141	positive regulation of microglial cell migration	CX3CL1	IDA		Human	PMID:10415068
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	Cx3cl1	IDA		Rat	PMID:20018408|RGD:9491804
Biological Process	GO:0010976	positive regulation of neuron projection development	Cx3cl1	IDA		Rat	PMID:23825416|RGD:8655547
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	CX3CL1	IGI	UniProtKB:P35411	Human	PMID:10869418
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	CX3CL1	IGI	UniProtKB:P35411	Human	PMID:10415068
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	CX3CL1	IGI	UniProtKB:P35411	Human	PMID:10869418
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Cx3cl1	IMP		Rat	PMID:12729461|RGD:13673777
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	CX3CL1	IGI	UniProtKB:P35411	Human	PMID:10415068
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	CX3CL1	IGI	UniProtKB:P35411	Human	PMID:10869418
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Cx3cl1	IDA		Rat	PMID:12729461|RGD:13673777
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Cx3cl1	IDA		Rat	PMID:17182651|RGD:4891893
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Cx3cl1	IDA		Rat	PMID:12729461|RGD:13673777
Biological Process	GO:0032914	positive regulation of transforming growth factor beta1 production	Cx3cl1	IMP	MGI:MGI:3608773	Mouse	PMID:18097059
Biological Process	GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway	CX3CL1	IDA		Human	PMID:10652441
Biological Process	GO:0001666	response to hypoxia	Cx3cl1	IEP		Rat	PMID:18630689|RGD:4891889
Biological Process	GO:0002931	response to ischemia	Cx3cl1	IGI	UniProtKB:P35411	Rat	PMID:12059974|RGD:13673875
Biological Process	GO:0042060	wound healing	Cx3cl1	IMP	MGI:MGI:3608773	Mouse	PMID:18097059

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern