Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Cx3cr1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CX3CR1
- Mouse genes Cx3cr1
- Rat genes Cx3cr1
- Zfish genes ccr2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cx3cr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019960	C-X3-C chemokine binding	CX3CR1	IDA		Human	PMID:23125415
Molecular Function	GO:0019960	C-X3-C chemokine binding	Cx3cr1	IPI	UniProtKB:P78423	Mouse	MGI:MGI:6162594\|PMID:10187784
Molecular Function	GO:0016495	C-X3-C chemokine receptor activity	CX3CR1	IDA		Human	PMID:12055230
Molecular Function	GO:0016495	C-X3-C chemokine receptor activity	CX3CR1	IDA		Human	PMID:9782118
Molecular Function	GO:0016495	C-X3-C chemokine receptor activity	Cx3cr1	IDA		Mouse	MGI:MGI:3833195\|PMID:18971423
Molecular Function	GO:0016495	C-X3-C chemokine receptor activity	Cx3cr1	IDA		Mouse	MGI:MGI:6162594\|PMID:10187784
Molecular Function	GO:0016495	C-X3-C chemokine receptor activity	Cx3cr1	IDA		Rat	PMID:11278650\|RGD:4892025
Molecular Function	GO:0004950	chemokine receptor activity	Cx3cr1	IMP		Rat	PMID:10415068\|RGD:13673824
Molecular Function	GO:0031737	CX3C chemokine receptor binding	CX3CR1	IDA		Human	PMID:9782118
Molecular Function	GO:0004896	cytokine receptor activity	Cx3cr1	IMP		Mouse	PMID:18971423
Molecular Function	GO:0004930	G protein-coupled receptor activity	Cx3cr1	IMP		Mouse	MGI:MGI:6162594\|PMID:10187784
Molecular Function	GO:0005515	protein binding	CX3CR1	IPI	UniProtKB:P78423	Human	PMID:9931005
Cellular Component	GO:0009986	cell surface	CX3CR1	IDA		Human	PMID:28791023
Cellular Component	GO:0009986	cell surface	Cx3cr1	IDA		Mouse	MGI:MGI:6162594\|PMID:10187784
Cellular Component	GO:0009986	cell surface	Cx3cr1	IDA		Rat	PMID:10415068\|RGD:13673824
Cellular Component	GO:0009986	cell surface	Cx3cr1	IDA		Rat	PMID:11870871\|RGD:4892001
Cellular Component	GO:0097447	dendritic tree	Cx3cr1	IDA		Rat	PMID:10869418\|RGD:4892026
Cellular Component	GO:0043005	neuron projection	Cx3cr1	IDA		Rat	PMID:10869418\|RGD:4892026
Cellular Component	GO:0032809	neuronal cell body membrane	Cx3cr1	IDA		Rat	PMID:10869418\|RGD:4892026
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Cx3cr1	IDA		Rat	PMID:11870871\|RGD:4892001
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Cx3cr1	IDA		Rat	PMID:19748551\|RGD:4891944
Cellular Component	GO:0005886	plasma membrane	CX3CR1	IDA		Human	PMID:12055230
Cellular Component	GO:0005886	plasma membrane	CX3CR1	IDA		Human	GO_REF:0000052
Biological Process	GO:0002250	adaptive immune response	Cx3cr1	IMP		Mouse	MGI:MGI:6110065\|PMID:29326275
Biological Process	GO:0061760	antifungal innate immune response	CX3CR1	IMP		Human	PMID:29326275
Biological Process	GO:0061760	antifungal innate immune response	Cx3cr1	IMP		Mouse	MGI:MGI:6110065\|PMID:29326275
Biological Process	GO:0035425	autocrine signaling	Cx3cr1	IGI	UniProtKB:O55145	Rat	PMID:12729461\|RGD:13673777
Biological Process	GO:0007420	brain development	Cx3cr1	IMP		Mouse	MGI:MGI:5287328\|PMID:21778362
Biological Process	GO:0007155	cell adhesion	CX3CR1	IDA		Human	PMID:9782118
Biological Process	GO:0007155	cell adhesion	Cx3cr1	IPI	UniProtKB:P78423	Mouse	MGI:MGI:6162594\|PMID:10187784
Biological Process	GO:0060326	cell chemotaxis	Cx3cr1	IMP		Rat	PMID:10415068\|RGD:13673824
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Cx3cr1	IGI	UniProtKB:P05067	Mouse	MGI:MGI:6162390\|PMID:23499256
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Cx3cr1	IEP		Rat	PMID:10422773\|RGD:4892028
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Cx3cr1	IEP		Rat	PMID:12446007\|RGD:4892023
Biological Process	GO:0021626	central nervous system maturation	Cx3cr1	IMP		Mouse	MGI:MGI:5576986\|PMID:24487234
Biological Process	GO:0070098	chemokine-mediated signaling pathway	Cx3cr1	IMP		Rat	PMID:10415068\|RGD:13673824
Biological Process	GO:0006935	chemotaxis	CX3CR1	IGI	UniProtKB:O55145	Human	PMID:16019082
Biological Process	GO:0048874	host-mediated regulation of intestinal microbiota composition	Cx3cr1	IMP		Mouse	MGI:MGI:6110065\|PMID:29326275
Biological Process	GO:0048874	host-mediated regulation of intestinal microbiota composition	Cx3cr1	IMP		Mouse	MGI:MGI:3526790\|PMID:15653504
Biological Process	GO:0006955	immune response	Cx3cr1	IMP		Mouse	MGI:MGI:3526790\|PMID:15653504
Biological Process	GO:0030595	leukocyte chemotaxis	Cx3cr1	IMP		Mouse	MGI:MGI:3770058\|PMID:16675847
Biological Process	GO:0050901	leukocyte tethering or rolling	Cx3cr1	IGI	UniProtKB:O00585,UniProtKB:P19320	Mouse	MGI:MGI:6162594\|PMID:10187784
Biological Process	GO:0007613	memory	Cx3cr1	IMP		Rat	PMID:23855980\|RGD:9491766
Biological Process	GO:0007613	memory	Cx3cr1	IMP		Rat	PMID:24447880\|RGD:9491776
Biological Process	GO:0001774	microglial cell activation	Cx3cr1	IMP		Rat	PMID:24447880\|RGD:9491776
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Cx3cr1	IMP		Mouse	MGI:MGI:5576986\|PMID:24487234
Biological Process	GO:0042117	monocyte activation	ccr2	IMP	ZFIN:ZDB-MRPHLNO-171025-3	Zfish	PMID:28844797
Biological Process	GO:0150090	multiple spine synapse organization, single dendrite	Cx3cr1	IMP		Mouse	MGI:MGI:5576986\|PMID:24487234
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	Cx3cr1	IGI	UniProtKB:P78423	Rat	PMID:10869418\|RGD:4892026
Biological Process	GO:0030336	negative regulation of cell migration	Cx3cr1	IMP		Rat	PMID:17114429\|RGD:4891970
Biological Process	GO:0002881	negative regulation of chronic inflammatory response to non-antigenic stimulus	Cx3cr1	IMP		Rat	PMID:24447880\|RGD:9491776
Biological Process	GO:0110091	negative regulation of hippocampal neuron apoptotic process	Cx3cr1	IGI	UniProtKB:P78423	Rat	PMID:10869418\|RGD:4892026
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	Cx3cr1	IMP		Rat	PMID:20018408\|RGD:9491804
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	Cx3cr1	IMP		Rat	PMID:23855980\|RGD:9491766
Biological Process	GO:1904150	negative regulation of microglial cell mediated cytotoxicity	Cx3cr1	IMP		Mouse	MGI:MGI:3639805\|PMID:16732273
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Cx3cr1	IMP		Mouse	MGI:MGI:6162594\|PMID:10187784
Biological Process	GO:0045766	positive regulation of angiogenesis	Cx3cr1	IMP		Rat	PMID:18006432\|RGD:4892022
Biological Process	GO:0045766	positive regulation of angiogenesis	Cx3cr1	IMP		Rat	PMID:22659346\|RGD:9491778
Biological Process	GO:1903721	positive regulation of I-kappaB phosphorylation	Cx3cr1	IGI	UniProtKB:P78423	Rat	PMID:10869418\|RGD:4892026
Biological Process	GO:1904141	positive regulation of microglial cell migration	Cx3cr1	IMP		Rat	PMID:10415068\|RGD:13673824
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	Cx3cr1	IMP		Mouse	MGI:MGI:3045506\|PMID:12871640
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	Cx3cr1	IMP		Rat	PMID:20018408\|RGD:9491804
Biological Process	GO:0050769	positive regulation of neurogenesis	Cx3cr1	IMP		Mouse	MGI:MGI:6189288\|PMID:20018408
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Cx3cr1	IGI	UniProtKB:P78423	Rat	PMID:10869418\|RGD:4892026
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Cx3cr1	IGI	UniProtKB:P78423	Rat	PMID:10869418\|RGD:4892026
Biological Process	GO:0045428	regulation of nitric oxide biosynthetic process	Cx3cr1	IGI	UniProtKB:P05067	Mouse	MGI:MGI:6162390\|PMID:23499256
Biological Process	GO:0032680	regulation of tumor necrosis factor production	Cx3cr1	IGI	UniProtKB:P05067	Mouse	MGI:MGI:6162390\|PMID:23499256
Biological Process	GO:0002931	response to ischemia	Cx3cr1	IGI	UniProtKB:O55145	Rat	PMID:12059974\|RGD:13673875
Biological Process	GO:0035176	social behavior	Cx3cr1	IMP		Mouse	MGI:MGI:5576986\|PMID:24487234
Biological Process	GO:0060074	synapse maturation	Cx3cr1	IMP		Mouse	MGI:MGI:5576986\|PMID:24487234
Biological Process	GO:0098883	synapse pruning	Cx3cr1	IMP		Mouse	MGI:MGI:5287328\|PMID:21778362

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.