Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CXCL10
  • Mouse genes Cxcl10
  • Rat genes Cxcl10
  • Zfish genes cxcl11.4,cxcl11.8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cxcl10

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042056	chemoattractant activity	CXCL10	IDA		Human	PMID:11157474
Molecular Function	GO:0008009	chemokine activity	CXCL10	IDA		Human	PMID:12782716
Molecular Function	GO:0008009	chemokine activity	Cxcl10	IDA		Rat	PMID:9288136|RGD:2311389
Molecular Function	GO:0048248	CXCR3 chemokine receptor binding	CXCL10	IDA		Human	PMID:12782716
Molecular Function	GO:0008201	heparin binding	CXCL10	IMP		Human	PMID:18645041
Molecular Function	GO:0005515	protein binding	CXCL10	IPI	UniProtKB:P27487	Human	PMID:18275857
Molecular Function	GO:0005515	protein binding	CXCL10	IPI	UniProtKB:P27487	Human	PMID:21314817
Molecular Function	GO:0005515	protein binding	CXCL10	IPI	UniProtKB:O00585	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CXCL10	IPI	UniProtKB:P02776	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CXCL10	IPI	UniProtKB:P13501	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CXCL10	IPI	UniProtKB:P48061	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CXCL10	IPI	UniProtKB:P51671	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CXCL10	IPI	UniProtKB:Q07325	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CXCL10	IPI	UniProtKB:Q99616	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CXCL10	IPI	UniProtKB:Q9NRJ3	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CXCL10	IPI	UniProtKB:Q9Y258	Human	PMID:28381538
Cellular Component	GO:0009897	external side of plasma membrane	Cxcl10	IDA		Mouse	PMID:19008373
Cellular Component	GO:0005576	extracellular region	CXCL10	IDA		Human	PMID:20041150
Cellular Component	GO:0005615	extracellular space	Cxcl10	IDA		Mouse	PMID:11894098
Cellular Component	GO:0005615	extracellular space	Cxcl10	IDA		Mouse	PMID:17277142
Cellular Component	GO:0005615	extracellular space	Cxcl10	IDA		Rat	PMID:17457469|RGD:2311382
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	CXCL10	IDA		Human	PMID:12782716
Biological Process	GO:0140374	antiviral innate immune response	CXCL10	IEP		Human	PMID:25930096
Biological Process	GO:0034605	cellular response to heat	Cxcl10	IEP		Rat	PMID:17457469|RGD:2311382
Biological Process	GO:0097398	cellular response to interleukin-17	Cxcl10	IDA		Mouse	PMID:30294880
Biological Process	GO:0071222	cellular response to lipopolysaccharide	CXCL10	IMP		Human	PMID:23776175
Biological Process	GO:0098586	cellular response to virus	CXCL10	IEP		Human	PMID:28146100
Biological Process	GO:0070098	chemokine-mediated signaling pathway	CXCL10	IMP		Human	PMID:18645041
Biological Process	GO:0006935	chemotaxis	CXCL10	IDA		Human	PMID:12782716
Biological Process	GO:0051607	defense response to virus	Cxcl10	IDA		Mouse	PMID:17277142
Biological Process	GO:0042118	endothelial cell activation	CXCL10	IGI	UniProtKB:P49682	Human	PMID:19470579
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	CXCL10	IMP		Human	PMID:12782716
Biological Process	GO:0006955	immune response	Cxcl10	IDA		Rat	PMID:12023393|RGD:625606
Biological Process	GO:0016525	negative regulation of angiogenesis	CXCL10	IDA		Human	PMID:7540647
Biological Process	GO:0016525	negative regulation of angiogenesis	Cxcl10	IDA		Rat	PMID:9288136|RGD:2311389
Biological Process	GO:0045662	negative regulation of myoblast differentiation	Cxcl10	IMP		Mouse	PMID:23844157
Biological Process	GO:1901740	negative regulation of myoblast fusion	Cxcl10	IMP		Mouse	PMID:23844157
Biological Process	GO:0030335	positive regulation of cell migration	Cxcl10	IDA		Rat	PMID:8798675|RGD:727661
Biological Process	GO:0008284	positive regulation of cell population proliferation	Cxcl10	IDA		Rat	PMID:8798675|RGD:727661
Biological Process	GO:0002690	positive regulation of leukocyte chemotaxis	Cxcl10	IDA		Rat	PMID:9288136|RGD:2311389
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	CXCL10	IDA		Human	PMID:8608232
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	CXCL10	IDA		Human	PMID:12782716
Biological Process	GO:2000406	positive regulation of T cell migration	CXCL10	IDA		Human	PMID:23620790
Biological Process	GO:0042981	regulation of apoptotic process	CXCL10	IDA		Human	PMID:22652417
Biological Process	GO:0042127	regulation of cell population proliferation	CXCL10	IDA		Human	PMID:12782716
Biological Process	GO:1901509	regulation of endothelial tube morphogenesis	CXCL10	IDA		Human	PMID:16484616
Biological Process	GO:0010819	regulation of T cell chemotaxis	CXCL10	IDA		Human	PMID:8608232
Biological Process	GO:0010996	response to auditory stimulus	Cxcl10	IEP		Rat	PMID:15519684|RGD:2289072
Biological Process	GO:0009617	response to bacterium	Cxcl10	IEP		Mouse	PMID:23012479
Biological Process	GO:0009409	response to cold	Cxcl10	IEP		Rat	PMID:16469832|RGD:2311385
Biological Process	GO:0010332	response to gamma radiation	Cxcl10	IEP		Rat	PMID:19084914|RGD:2306303
Biological Process	GO:0032496	response to lipopolysaccharide	Cxcl10	IEP		Rat	PMID:9288136|RGD:2311389
Biological Process	GO:0032496	response to lipopolysaccharide	cxcl11.8	IDA		Zfish	PMID:19381848
Biological Process	GO:0009615	response to virus	Cxcl10	IEP		Rat	PMID:12909590|RGD:2311388
Biological Process	GO:0033280	response to vitamin D	Cxcl10	IEP		Rat	PMID:15637289|RGD:2311387
Biological Process	GO:0010818	T cell chemotaxis	CXCL10	IMP		Human	PMID:18645041

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern