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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Cxcl12

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cxcl12
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0042056chemoattractant activitycxcl12aIMPZFIN:ZDB-GENO-200709-9ZfishPMID:31371827
Molecular FunctionGO:0042056chemoattractant activitycxcl12aIMPZfishPMID:16129886
Molecular FunctionGO:0042056chemoattractant activitycxcl12aIDAZfishPMID:18579679
Molecular FunctionGO:0042056chemoattractant activitycxcl12bIDAZfishPMID:18579679
Molecular FunctionGO:0008009chemokine activityCXCL12IDAHumanPMID:18308860
Molecular FunctionGO:0008009chemokine activityCXCL12IMPHumanPMID:27400149
Molecular FunctionGO:0008009chemokine activityCxcl12IDAMousePMID:12183377
Molecular FunctionGO:0042379chemokine receptor bindingCXCL12IMPHumanPMID:22457824
Molecular FunctionGO:0045236CXCR chemokine receptor bindingCXCL12IDAHumanPMID:20388803
Molecular FunctionGO:0005178integrin bindingCXCL12IDAHumanPMID:29301984
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:O00585HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:O14625HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:O15444HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:O95715HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:P02776HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:P02778HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:P10720HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:P13501HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:P13501:PRO_0000005175HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:P19875HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:P47992HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:P51671HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:P78556HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:P80162HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:Q07325HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:Q6UXB2HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:Q99616HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:Q9NRJ3HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:Q9UBD3HumanPMID:28381538
Molecular FunctionGO:0005515protein bindingCXCL12IPIUniProtKB:Q9Y258HumanPMID:28381538
Cellular ComponentGO:0062023collagen-containing extracellular matrixCXCL12HDAHumanPMID:25037231
Cellular ComponentGO:0005737cytoplasmCxcl12IDARatPMID:24924806|RGD:11352662
Cellular ComponentGO:0009897external side of plasma membraneCxcl12IDAMousePMID:19008373
Cellular ComponentGO:0070062extracellular exosomeCXCL12HDAHumanPMID:23533145
Cellular ComponentGO:0005615extracellular spaceCxcl12IDARatPMID:11820456|RGD:632503
Cellular ComponentGO:0140494migrasomecxcl12aIMPZFIN:ZDB-GENO-200709-9ZfishPMID:31371827
Cellular ComponentGO:0005634nucleusCxcl12IDARatPMID:29550796|RGD:13792610
Cellular ComponentGO:0005886plasma membraneCxcl12IDARatPMID:17046839|RGD:2306583
Biological ProcessGO:0008344adult locomotory behaviorCxcl12IMPRatPMID:19303923|RGD:2306565
Biological ProcessGO:0009887animal organ morphogenesiscxcl12aIMPZfishPMID:11748832
Biological ProcessGO:0031100animal organ regenerationCxcl12IMPRatPMID:17148669|RGD:2306581
Biological ProcessGO:0007411axon guidancecxcl12aIGIZFIN:ZDB-MRPHLNO-050318-6,ZFIN:ZDB-MRPHLNO-050318-7ZfishPMID:15716407
Biological ProcessGO:0007411axon guidancecxcl12aIMPZFIN:ZDB-MRPHLNO-050324-1ZfishPMID:15659553
Biological ProcessGO:0007411axon guidancecxcl12aIMPZFIN:ZDB-MRPHLNO-050324-1ZfishPMID:19595689
Biological ProcessGO:0043534blood vessel endothelial cell migrationCxcl12IMPMGI:MGI:1934384MousePMID:15626744
Biological ProcessGO:0007420brain developmentCxcl12IDAMousePMID:12183377
Biological ProcessGO:0007420brain developmentCxcl12IEPRatPMID:12401342|RGD:1358280
Biological ProcessGO:0001569branching involved in blood vessel morphogenesisCxcl12IMPMGI:MGI:1934384MousePMID:15626744
Biological ProcessGO:0060326cell chemotaxisCXCL12IDAHumanPMID:18308860
Biological ProcessGO:0042074cell migration involved in gastrulationcxcl12aIMPZFIN:ZDB-MRPHLNO-051028-2ZfishPMID:18579679
Biological ProcessGO:0042074cell migration involved in gastrulationcxcl12aIGIZFIN:ZDB-MRPHLNO-051028-1,ZFIN:ZDB-MRPHLNO-051028-2ZfishPMID:18579679
Biological ProcessGO:0042074cell migration involved in gastrulationcxcl12bIMPZFIN:ZDB-MRPHLNO-051028-1ZfishPMID:18579679
Biological ProcessGO:0042074cell migration involved in gastrulationcxcl12bIGIZFIN:ZDB-MRPHLNO-051028-1,ZFIN:ZDB-MRPHLNO-051028-2ZfishPMID:18579679
Biological ProcessGO:0002042cell migration involved in sprouting angiogenesiscxcl12bIGIZFIN:ZDB-MRPHLNO-110429-2,ZFIN:ZDB-MRPHLNO-110429-3ZfishPMID:21429985
Biological ProcessGO:0002042cell migration involved in sprouting angiogenesiscxcl12bIMPZFIN:ZDB-MRPHLNO-110429-2ZfishPMID:21429985
Biological ProcessGO:0000902cell morphogenesiscxcl12aIGIZFIN:ZDB-MRPHLNO-051028-1,ZFIN:ZDB-MRPHLNO-051028-2ZfishPMID:18579679
Biological ProcessGO:0000902cell morphogenesiscxcl12bIGIZFIN:ZDB-MRPHLNO-051028-1,ZFIN:ZDB-MRPHLNO-051028-2ZfishPMID:18579679
Biological ProcessGO:0098609cell-cell adhesionCxcl12IDAMousePMID:20847314
Biological ProcessGO:1990869cellular response to chemokineCXCL12IMPHumanPMID:27400149
Biological ProcessGO:0038146chemokine (C-X-C motif) ligand 12 signaling pathwayCXCL12IMPHumanPMID:27400149
Biological ProcessGO:0070098chemokine-mediated signaling pathwayCXCL12IDAHumanPMID:20388803
Biological ProcessGO:0006935chemotaxiscxcl12aIGIZFIN:ZDB-GENO-140207-11,ZFIN:ZDB-MRPHLNO-140205-5,ZFIN:ZDB-MRPHLNO-140205-6ZfishPMID:24119842
Biological ProcessGO:0006935chemotaxiscxcl12aIMPZFIN:ZDB-GENO-101119-34ZfishPMID:24119842
Biological ProcessGO:0050966detection of mechanical stimulus involved in sensory perception of painCxcl12IMPRatPMID:27760212|RGD:12910551
Biological ProcessGO:0050965detection of temperature stimulus involved in sensory perception of painCxcl12IMPRatPMID:27760212|RGD:12910551
Biological ProcessGO:0071542dopaminergic neuron differentiationCxcl12IDAMouseMGI:MGI:5700491|PMID:22535492
Biological ProcessGO:0031101fin regenerationcxcl12aIMPZfishPMID:19503807
Biological ProcessGO:0031101fin regenerationcxcl12aIDAZfishPMID:16586100
Biological ProcessGO:0030900forebrain developmentcxcl12aIMPZFIN:ZDB-MRPHLNO-050324-1ZfishPMID:19595689
Biological ProcessGO:0007281germ cell developmentCxcl12IDAMousePMID:12900445
Biological ProcessGO:0008354germ cell migrationCxcl12IDAMousePMID:12900445
Biological ProcessGO:0008354germ cell migrationcxcl12aIMPZfishPMID:15068797
Biological ProcessGO:0008354germ cell migrationcxcl12aIMPZFIN:ZDB-GENO-131017-4ZfishPMID:23826390
Biological ProcessGO:0008354germ cell migrationcxcl12aIMPZfishPMID:16129886
Biological ProcessGO:0008354germ cell migrationcxcl12aIMPZfishPMID:12464177
Biological ProcessGO:0035701hematopoietic stem cell migrationcxcl12aIGIZFIN:ZDB-GENE-040426-2132ZfishPMID:28416284
Biological ProcessGO:0030097hemopoiesiscxcl12bIMPZFIN:ZDB-MRPHLNO-141113-3ZfishPMID:25119043
Biological ProcessGO:0050930induction of positive chemotaxisCxcl12IDAMousePMID:12900445
Biological ProcessGO:0050930induction of positive chemotaxiscxcl12aIMPZfishPMID:15068797
Biological ProcessGO:0050930induction of positive chemotaxiscxcl12aIMPZfishPMID:15081362
Biological ProcessGO:0050930induction of positive chemotaxiscxcl12bIGIZFIN:ZDB-GENE-030318-1ZfishPMID:15081362
Biological ProcessGO:0033622integrin activationCXCL12IDAHumanPMID:29301984
Biological ProcessGO:0070121Kupffer's vesicle developmentcxcl12bIGIZFIN:ZDB-GENE-980526-176ZfishPMID:31430272
Biological ProcessGO:0070121Kupffer's vesicle developmentcxcl12bIMPZFIN:ZDB-GENO-200330-3ZfishPMID:31430272
Biological ProcessGO:0001946lymphangiogenesiscxcl12aIMPZFIN:ZDB-MRPHLNO-071022-5ZfishPMID:24903752
Biological ProcessGO:0097535lymphoid lineage cell migration into thymuscxcl12aIGIZFIN:ZDB-MRPHLNO-071113-1,ZFIN:ZDB-MRPHLNO-121001-4ZfishPMID:22342843
Biological ProcessGO:0097535lymphoid lineage cell migration into thymuscxcl12bIGIZFIN:ZDB-MRPHLNO-071113-1,ZFIN:ZDB-MRPHLNO-121001-4ZfishPMID:22342843
Biological ProcessGO:0097535lymphoid lineage cell migration into thymuscxcl12bIGIZFIN:ZDB-MRPHLNO-071113-1,ZFIN:ZDB-MRPHLNO-121001-6ZfishPMID:22342843
Biological ProcessGO:0097535lymphoid lineage cell migration into thymuscxcl12bIMPZFIN:ZDB-MRPHLNO-071113-1ZfishPMID:22342843
Biological ProcessGO:0008045motor neuron axon guidanceCxcl12IMPMGI:MGI:1934384MousePMID:16129397
Biological ProcessGO:0030239myofibril assemblycxcl12aIMPZFIN:ZDB-MRPHLNO-071022-4ZfishPMID:17517144
Biological ProcessGO:0008285negative regulation of cell population proliferationCxcl12IGIMGI:MGI:109562MousePMID:22956548
Biological ProcessGO:0008285negative regulation of cell population proliferationCxcl12IGIMGI:MGI:1341264MousePMID:22956548
Biological ProcessGO:0008285negative regulation of cell population proliferationcxcl12aIDAZfishPMID:16586100
Biological ProcessGO:2000669negative regulation of dendritic cell apoptotic processCXCL12IDAHumanPMID:15059845
Biological ProcessGO:2000472negative regulation of hematopoietic stem cell migrationcxcl12aIGIZFIN:ZDB-GENO-130204-7,ZFIN:ZDB-MRPHLNO-051028-2ZfishPMID:21856868
Biological ProcessGO:1902230negative regulation of intrinsic apoptotic signaling pathway in response to DNA damageCXCL12IDAHumanPMID:20388803
Biological ProcessGO:1903237negative regulation of leukocyte tethering or rollingCXCL12IDAHumanPMID:18308860
Biological ProcessGO:0090024negative regulation of neutrophil chemotaxiscxcl12aIGIZFIN:ZDB-GENO-110209-3,ZFIN:ZDB-MRPHLNO-051028-3ZfishPMID:20592249
Biological ProcessGO:0001764neuron migrationCxcl12IDARatPMID:12401342|RGD:1358280
Biological ProcessGO:0001764neuron migrationcxcl12aIGIZFIN:ZDB-GENO-101119-34,ZFIN:ZDB-MRPHLNO-051028-1ZfishPMID:23382464
Biological ProcessGO:0001764neuron migrationcxcl12aIMPZFIN:ZDB-MRPHLNO-050324-1ZfishPMID:19595689
Biological ProcessGO:0001764neuron migrationcxcl12aIMPZFIN:ZDB-MRPHLNO-050324-1ZfishPMID:15659553
Biological ProcessGO:0001764neuron migrationcxcl12aIMPZfishPMID:16129396
Biological ProcessGO:0001764neuron migrationcxcl12bIMPZFIN:ZDB-MRPHLNO-051028-1ZfishPMID:16129396
Biological ProcessGO:0001764neuron migrationcxcl12bIGIZFIN:ZDB-GENO-101119-34,ZFIN:ZDB-MRPHLNO-051028-1ZfishPMID:23382464
Biological ProcessGO:0048842positive regulation of axon extension involved in axon guidanceCxcl12IMPRatPMID:18701697|RGD:2306571
Biological ProcessGO:0048842positive regulation of axon extension involved in axon guidancecxcl12aIDAZfishPMID:17267551
Biological ProcessGO:0090280positive regulation of calcium ion importCxcl12IDAMousePMID:8962122
Biological ProcessGO:0045785positive regulation of cell adhesionCXCL12IDAHumanPMID:23620790
Biological ProcessGO:0030335positive regulation of cell migrationCxcl12IDAMousePMID:12900445
Biological ProcessGO:0030335positive regulation of cell migrationCxcl12IMPRatPMID:11820456|RGD:632503
Biological ProcessGO:0030335positive regulation of cell migrationCxcl12IMPRatPMID:19327017|RGD:2306564
Biological ProcessGO:0030335positive regulation of cell migrationcxcl12aIMPZFIN:ZDB-GENO-070123-6ZfishPMID:16678780
Biological ProcessGO:0030335positive regulation of cell migrationcxcl12aIMPZFIN:ZDB-MRPHLNO-050324-1ZfishPMID:17267445
Biological ProcessGO:0030335positive regulation of cell migrationcxcl12aIMPZfishPMID:12444253
Biological ProcessGO:0008284positive regulation of cell population proliferationCxcl12IMPRatPMID:17425785|RGD:2306580
Biological ProcessGO:0050921positive regulation of chemotaxisCxcl12IGIMGI:MGI:1341264MousePMID:22956548
Biological ProcessGO:0033603positive regulation of dopamine secretionCxcl12IDARatPMID:18671738|RGD:2306573
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationCxcl12IMPRatPMID:18690419|RGD:2306572
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeCxcl12IGIMGI:MGI:1341264MousePMID:22956548
Biological ProcessGO:0090026positive regulation of monocyte chemotaxisCXCL12IDAHumanPMID:18802065
Biological ProcessGO:1901741positive regulation of myoblast fusionCxcl12IMPMousePMID:23844157
Biological ProcessGO:0045666positive regulation of neuron differentiationCxcl12IMPRatPMID:17425785|RGD:2306580
Biological ProcessGO:0051897positive regulation of protein kinase B signalingCxcl12IGIMGI:MGI:1341264MousePMID:22956548
Biological ProcessGO:2000406positive regulation of T cell migrationCXCL12IDAHumanPMID:23620790
Biological ProcessGO:0048920posterior lateral line neuromast primordium migrationcxcl12aIMPZFIN:ZDB-GENO-101119-34ZfishPMID:24119842
Biological ProcessGO:0048920posterior lateral line neuromast primordium migrationcxcl12aIMPZFIN:ZDB-MRPHLNO-051028-3ZfishPMID:29945870
Biological ProcessGO:0048920posterior lateral line neuromast primordium migrationcxcl12aIMPZFIN:ZDB-MRPHLNO-050324-1ZfishPMID:17394634
Biological ProcessGO:0048920posterior lateral line neuromast primordium migrationcxcl12aIGIZFIN:ZDB-MRPHLNO-050324-1,ZFIN:ZDB-MRPHLNO-081216-1ZfishPMID:18585376
Biological ProcessGO:0048920posterior lateral line neuromast primordium migrationcxcl12aIGIZFIN:ZDB-GENO-140207-11,ZFIN:ZDB-MRPHLNO-140205-5,ZFIN:ZDB-MRPHLNO-140205-6ZfishPMID:24119842
Biological ProcessGO:0048920posterior lateral line neuromast primordium migrationcxcl12aIGIZFIN:ZDB-MRPHLNO-050324-1,ZFIN:ZDB-MRPHLNO-100608-9ZfishPMID:20308561
Biological ProcessGO:0048920posterior lateral line neuromast primordium migrationcxcl12aIMPZFIN:ZDB-GENO-101119-34ZfishPMID:17570670
Biological ProcessGO:0048920posterior lateral line neuromast primordium migrationcxcl12aIMPZFIN:ZDB-MRPHLNO-050324-1ZfishPMID:20308561
Biological ProcessGO:0030516regulation of axon extensioncxcl12aIMPZfishPMID:15081362
Biological ProcessGO:0051924regulation of calcium ion transportCxcl12IDARatPMID:18671738|RGD:2306573
Biological ProcessGO:0030334regulation of cell migrationCxcl12IGIMGI:MGI:1306805MousePMID:19064997
Biological ProcessGO:0030334regulation of cell migrationCxcl12IDAMousePMID:12183377
Biological ProcessGO:0106014regulation of inflammatory response to woundingcxcl12aIMPZFIN:ZDB-GENO-101119-34ZfishPMID:28220184
Biological ProcessGO:0051453regulation of intracellular pHcxcl12aIGIZFIN:ZDB-GENE-030721-1ZfishPMID:25843033
Biological ProcessGO:0051453regulation of intracellular pHcxcl12bIGIZFIN:ZDB-GENE-030318-1ZfishPMID:25843033
Biological ProcessGO:0090022regulation of neutrophil chemotaxiscxcl12aIMPZFIN:ZDB-GENO-101119-34ZfishPMID:28220184
Biological ProcessGO:0009408response to heatCxcl12IEPRatPMID:18552407|RGD:2306574
Biological ProcessGO:0001666response to hypoxiaCxcl12IEPRatPMID:17581219|RGD:2306578
Biological ProcessGO:0009612response to mechanical stimulusCxcl12IEPRatPMID:17145991|RGD:2306582
Biological ProcessGO:0043434response to peptide hormoneCxcl12IEPRatPMID:19294511|RGD:2306566
Biological ProcessGO:0009314response to radiationCxcl12IEPRatPMID:19024651|RGD:2306569
Biological ProcessGO:1990478response to ultrasoundCxcl12IEPRatPMID:25181476|RGD:11352664
Biological ProcessGO:0031290retinal ganglion cell axon guidancecxcl12aIDAZfishPMID:17267551
Biological ProcessGO:0031290retinal ganglion cell axon guidancecxcl12aIGIZFIN:ZDB-GENO-070412-4,ZFIN:ZDB-MRPHLNO-050318-6ZfishPMID:17267551
Biological ProcessGO:0031290retinal ganglion cell axon guidancecxcl12bIGIZFIN:ZDB-GENO-070412-4,ZFIN:ZDB-MRPHLNO-051028-1ZfishPMID:17267551
Biological ProcessGO:0002040sprouting angiogenesiscxcl12bIMPZFIN:ZDB-GENO-110513-4ZfishPMID:21429983
Biological ProcessGO:0055002striated muscle cell developmentcxcl12aIMPZFIN:ZDB-MRPHLNO-071022-4ZfishPMID:17517144
Biological ProcessGO:0042098T cell proliferationCxcl12IMPMGI:MGI:1934384MousePMID:12707343
Biological ProcessGO:0022029telencephalon cell migrationCxcl12IMPRatPMID:16971524|RGD:2306584
Biological ProcessGO:0021730trigeminal sensory nucleus developmentcxcl12aIGIZFIN:ZDB-GENO-101119-34,ZFIN:ZDB-MRPHLNO-051028-1ZfishPMID:23382464
Biological ProcessGO:0021730trigeminal sensory nucleus developmentcxcl12bIGIZFIN:ZDB-GENO-101119-34,ZFIN:ZDB-MRPHLNO-051028-1ZfishPMID:23382464
Biological ProcessGO:0001570vasculogenesiscxcl12bIMPZFIN:ZDB-MRPHLNO-051028-1ZfishPMID:19797767

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory