Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CXCL1,CXCL2,CXCL3
  • Mouse genes Cxcl2
  • Rat genes Cxcl2
  • Zfish genes cxcl8a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cxcl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008009	chemokine activity	Cxcl2	IDA		Rat	PMID:10975996|RGD:5135014
Molecular Function	GO:0008009	chemokine activity	cxcl8a	IDA		Zfish	PMID:27815178
Molecular Function	GO:0005515	protein binding	CXCL1	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CXCL2	IPI	UniProtKB:P27487	Human	PMID:18275857
Molecular Function	GO:0005515	protein binding	CXCL2	IPI	UniProtKB:P27487	Human	PMID:21314817
Molecular Function	GO:0005515	protein binding	CXCL2	IPI	UniProtKB:P02776	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CXCL2	IPI	UniProtKB:P13501	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CXCL2	IPI	UniProtKB:P48061	Human	PMID:28381538
Cellular Component	GO:0005615	extracellular space	CXCL3	IDA		Human	PMID:10095777
Cellular Component	GO:0005615	extracellular space	Cxcl2	IDA		Mouse	PMID:25084278
Cellular Component	GO:0005615	extracellular space	Cxcl2	IDA		Mouse	PMID:16239543
Cellular Component	GO:0005615	extracellular space	Cxcl2	IDA		Mouse	PMID:16618742
Cellular Component	GO:0005615	extracellular space	Cxcl2	IDA		Mouse	PMID:21148126
Cellular Component	GO:0005615	extracellular space	Cxcl2	IDA		Mouse	PMID:12055258
Cellular Component	GO:0005615	extracellular space	Cxcl2	IDA		Rat	PMID:20724665|RGD:5134960
Biological Process	GO:0001525	angiogenesis	cxcl8a	IDA		Zfish	PMID:28949016
Biological Process	GO:0071347	cellular response to interleukin-1	Cxcl2	IEP		Rat	PMID:16239643|RGD:5135237
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Cxcl2	IEP		Rat	PMID:16239643|RGD:5135237
Biological Process	GO:0071219	cellular response to molecule of bacterial origin	cxcl8a	IDA		Zfish	PMID:31900206
Biological Process	GO:0071305	cellular response to vitamin D	cxcl8a	IMP	ZFIN:ZDB-MRPHLNO-120222-5	Zfish	PMID:27705794
Biological Process	GO:0071305	cellular response to vitamin D	cxcl8a	IMP	ZFIN:ZDB-GENO-151016-4	Zfish	PMID:27705794
Biological Process	GO:0098508	endothelial to hematopoietic transition	cxcl8a	IMP	ZFIN:ZDB-MRPHLNO-120222-5	Zfish	PMID:25870200
Biological Process	GO:0071621	granulocyte chemotaxis	cxcl8a	IDA		Zfish	PMID:27815178
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	cxcl8a	IMP	ZFIN:ZDB-MRPHLNO-120222-5	Zfish	PMID:25870200
Biological Process	GO:0060218	hematopoietic stem cell differentiation	cxcl8a	IMP	ZFIN:ZDB-MRPHLNO-120222-5	Zfish	PMID:25870200
Biological Process	GO:0030595	leukocyte chemotaxis	Cxcl2	IMP		Rat	PMID:11837784|RGD:727566
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	cxcl8a	IMP	ZFIN:ZDB-GENO-151016-4	Zfish	PMID:28538177
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	cxcl8a	IMP	ZFIN:ZDB-MRPHLNO-140630-1	Zfish	PMID:23509368
Biological Process	GO:0030593	neutrophil chemotaxis	Cxcl2	IMP		Rat	PMID:12460233|RGD:632969
Biological Process	GO:0030593	neutrophil chemotaxis	cxcl8a	IMP	ZFIN:ZDB-MRPHLNO-140630-1	Zfish	PMID:25445910
Biological Process	GO:0030593	neutrophil chemotaxis	cxcl8a	IDA		Zfish	PMID:23219724
Biological Process	GO:0030593	neutrophil chemotaxis	cxcl8a	IMP	ZFIN:ZDB-MRPHLNO-130219-5	Zfish	PMID:27806130
Biological Process	GO:0030593	neutrophil chemotaxis	cxcl8a	IMP	ZFIN:ZDB-MRPHLNO-130219-5	Zfish	PMID:23219724
Biological Process	GO:1990266	neutrophil migration	cxcl8a	IMP	ZFIN:ZDB-GENO-151016-4	Zfish	PMID:28538177
Biological Process	GO:1990266	neutrophil migration	cxcl8a	IMP	ZFIN:ZDB-MRPHLNO-140630-1	Zfish	PMID:28642884
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Cxcl2	IDA		Rat	PMID:10975996|RGD:5135014
Biological Process	GO:0002631	regulation of granuloma formation	cxcl8a	IMP	ZFIN:ZDB-MRPHLNO-130219-5	Zfish	PMID:27806130
Biological Process	GO:0002631	regulation of granuloma formation	cxcl8a	IGI	ZFIN:ZDB-GENE-040426-2252	Zfish	PMID:27806130
Biological Process	GO:0001975	response to amphetamine	Cxcl2	IEP		Rat	PMID:19582783|RGD:2314489
Biological Process	GO:0009617	response to bacterium	cxcl8a	IMP	ZFIN:ZDB-MRPHLNO-140630-1	Zfish	PMID:25445910
Biological Process	GO:0009617	response to bacterium	cxcl8a	IGI	ZFIN:ZDB-GENE-040426-2252	Zfish	PMID:27806130
Biological Process	GO:0009617	response to bacterium	cxcl8a	IMP	ZFIN:ZDB-MRPHLNO-130219-5	Zfish	PMID:27806130
Biological Process	GO:0032355	response to estradiol	Cxcl2	IEP		Rat	PMID:20709317|RGD:5134961
Biological Process	GO:0010332	response to gamma radiation	Cxcl2	IEP		Rat	PMID:20185578|RGD:5134998
Biological Process	GO:0051384	response to glucocorticoid	Cxcl2	IEP		Rat	PMID:20728373|RGD:5134959
Biological Process	GO:0009408	response to heat	Cxcl2	IEP		Rat	PMID:19582783|RGD:2314489
Biological Process	GO:0002237	response to molecule of bacterial origin	CXCL2	IDA		Human	PMID:19912257
Biological Process	GO:0002237	response to molecule of bacterial origin	Cxcl2	IDA		Mouse	MGI:MGI:4943853|PMID:19912257
Biological Process	GO:1901698	response to nitrogen compound	cxcl8a	IDA		Zfish	PMID:31900206
Biological Process	GO:0014070	response to organic cyclic compound	cxcl8a	IDA		Zfish	PMID:31900206
Biological Process	GO:0009611	response to wounding	cxcl8a	IMP	ZFIN:ZDB-MRPHLNO-140630-1	Zfish	PMID:23509368
Biological Process	GO:0001570	vasculogenesis	cxcl8a	IMP	ZFIN:ZDB-MRPHLNO-120222-6	Zfish	PMID:21493894
Biological Process	GO:0001570	vasculogenesis	cxcl8a	IMP	ZFIN:ZDB-MRPHLNO-120222-5	Zfish	PMID:21493894
Biological Process	GO:0042060	wound healing	Cxcl2	IEP		Rat	PMID:21345009|RGD:5135066

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern