Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CXCR1
  • Mouse genes Cxcr1
  • Rat genes Cxcr1
  • Zfish genes cxcr2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cxcr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051916	granulocyte colony-stimulating factor binding	cxcr2	IGI	ZFIN:ZDB-GENE-090313-165	Zfish	PMID:27815178
Molecular Function	GO:0019959	interleukin-8 binding	CXCR1	IPI	UniProtKB:P10145	Human	PMID:11564821
Molecular Function	GO:0004918	interleukin-8 receptor activity	CXCR1	IDA		Human	PMID:10734056
Molecular Function	GO:0005515	protein binding	CXCR1	IPI	UniProtKB:P10145	Human	PMID:30384436
Molecular Function	GO:0005515	protein binding	CXCR1	IPI	UniProtKB:A5PKU2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CXCR1	IPI	UniProtKB:P24593	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CXCR1	IPI	UniProtKB:Q969F0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CXCR1	IPI	UniProtKB:Q9NY35	Human	PMID:32296183
Biological Process	GO:0007166	cell surface receptor signaling pathway	CXCR1	IDA		Human	PMID:10734056
Biological Process	GO:0042742	defense response to bacterium	cxcr2	IMP	ZFIN:ZDB-MRPHLNO-140915-1	Zfish	PMID:23475575
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	cxcr2	IMP	ZFIN:ZDB-GENO-190805-2	Zfish	PMID:28538177
Biological Process	GO:0042119	neutrophil activation	cxcr2	IMP	ZFIN:ZDB-MRPHLNO-140915-1	Zfish	PMID:23475575
Biological Process	GO:1990266	neutrophil migration	cxcr2	IMP	ZFIN:ZDB-GENO-190805-2	Zfish	PMID:28538177
Biological Process	GO:0031623	receptor internalization	CXCR1	IDA		Human	PMID:10734056

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern