Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CXCR2
  • Mouse genes Cxcr2
  • Rat genes Cxcr2
  • Zfish genes cxcr2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cxcr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016494	C-X-C chemokine receptor activity	CXCR2	IDA		Human	PMID:10878382
Molecular Function	GO:0004950	chemokine receptor activity	Cxcr2	IDA		Mouse	PMID:16618742
Molecular Function	GO:0004930	G protein-coupled receptor activity	CXCR2	IDA		Human	PMID:10438939
Molecular Function	GO:0051916	granulocyte colony-stimulating factor binding	cxcr2	IGI	ZFIN:ZDB-GENE-090313-165	Zfish	PMID:27815178
Molecular Function	GO:0019959	interleukin-8 binding	CXCR2	IPI	UniProtKB:P10145	Human	PMID:1840701
Molecular Function	GO:0004918	interleukin-8 receptor activity	CXCR2	IDA		Human	PMID:10820279
Molecular Function	GO:0005515	protein binding	CXCR2	IPI	UniProtKB:P04233	Human	PMID:17435771
Molecular Function	GO:0005515	protein binding	CXCR2	IPI	UniProtKB:P46940	Human	PMID:21876773
Molecular Function	GO:0005515	protein binding	CXCR2	IPI	UniProtKB:P10145	Human	PMID:22904195
Molecular Function	GO:0005515	protein binding	CXCR2	IPI	UniProtKB:P10145	Human	PMID:23597562
Molecular Function	GO:0005515	protein binding	CXCR2	IPI	UniProtKB:A5PKU2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CXCR2	IPI	UniProtKB:P54849	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CXCR2	IPI	UniProtKB:Q05940	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CXCR2	IPI	UniProtKB:Q14318	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CXCR2	IPI	UniProtKB:Q8N7P3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CXCR2	IPI	UniProtKB:Q8WVX3-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CXCR2	IPI	UniProtKB:Q96HE8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CXCR2	IPI	UniProtKB:Q9BVK8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CXCR2	IPI	UniProtKB:Q9HD20-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CXCR2	IPI	UniProtKB:Q9NP94	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CXCR2	IPI	UniProtKB:Q9NRQ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Cxcr2	IPI	UniProtKB:Q6W5C0	Mouse	MGI:MGI:3028809|PMID:14764687
Cellular Component	GO:0009986	cell surface	CXCR2	IDA		Human	PMID:10878382
Cellular Component	GO:0042629	mast cell granule	CXCR2	IDA		Human	PMID:9725262
Cellular Component	GO:0016020	membrane	CXCR2	IDA		Human	PMID:10725748
Cellular Component	GO:0015630	microtubule cytoskeleton	CXCR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0072686	mitotic spindle	CXCR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	CXCR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CXCR2	IDA		Human	GO_REF:0000052
Biological Process	GO:0002438	acute inflammatory response to antigenic stimulus	Cxcr2	IMP		Rat	PMID:15516486|RGD:7257704
Biological Process	GO:0007166	cell surface receptor signaling pathway	CXCR2	IDA		Human	PMID:10734056
Biological Process	GO:0007166	cell surface receptor signaling pathway	CXCR2	IDA		Human	PMID:10878382
Biological Process	GO:0006968	cellular defense response	CXCR2	IDA		Human	PMID:10725748
Biological Process	GO:0006935	chemotaxis	CXCR2	IDA		Human	PMID:10725748
Biological Process	GO:0042742	defense response to bacterium	cxcr2	IMP	ZFIN:ZDB-MRPHLNO-140915-1	Zfish	PMID:23475575
Biological Process	GO:0038112	interleukin-8-mediated signaling pathway	CXCR2	IDA		Human	PMID:10820279
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	cxcr2	IMP	ZFIN:ZDB-GENO-190805-2	Zfish	PMID:28538177
Biological Process	GO:0072173	metanephric tubule morphogenesis	Cxcr2	IMP		Rat	PMID:17634442|RGD:7257700
Biological Process	GO:0030901	midbrain development	Cxcr2	IEP		Rat	PMID:18436867|RGD:4892032
Biological Process	GO:0043066	negative regulation of apoptotic process	Cxcr2	IMP		Mouse	PMID:16618742
Biological Process	GO:0043066	negative regulation of apoptotic process	Cxcr2	IMP		Rat	PMID:17634442|RGD:7257700
Biological Process	GO:0033030	negative regulation of neutrophil apoptotic process	Cxcr2	IMP		Rat	PMID:22312020|RGD:7257693
Biological Process	GO:0042119	neutrophil activation	CXCR2	IDA		Human	PMID:10878382
Biological Process	GO:0042119	neutrophil activation	cxcr2	IMP	ZFIN:ZDB-MRPHLNO-140915-1	Zfish	PMID:23475575
Biological Process	GO:0030593	neutrophil chemotaxis	CXCR2	IDA		Human	PMID:10820279
Biological Process	GO:0030593	neutrophil chemotaxis	Cxcr2	IMP		Rat	PMID:10975996|RGD:5135014
Biological Process	GO:1990266	neutrophil migration	cxcr2	IMP	ZFIN:ZDB-GENO-190805-2	Zfish	PMID:28538177
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	CXCR2	IDA		Human	PMID:10438939
Biological Process	GO:0045766	positive regulation of angiogenesis	Cxcr2	IMP		Rat	PMID:18832730|RGD:7257696
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	Cxcr2	IMP		Rat	PMID:22562555|RGD:7257691
Biological Process	GO:0008284	positive regulation of cell population proliferation	CXCR2	IDA		Human	PMID:10438939
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Cxcr2	IDA		Rat	PMID:10975996|RGD:5135014
Biological Process	GO:0002690	positive regulation of leukocyte chemotaxis	Cxcr2	IMP		Rat	PMID:17717298|RGD:7257697
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	Cxcr2	IMP		Rat	PMID:23947621|RGD:7257689
Biological Process	GO:0043117	positive regulation of vascular permeability	Cxcr2	IMP		Rat	PMID:19255141|RGD:7257695
Biological Process	GO:0031623	receptor internalization	CXCR2	IDA		Human	PMID:10734056

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern