Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYBB
  • Mouse genes Cybb
  • Rat genes Cybb
  • Zfish genes cybb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cybb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0009055	electron transfer activity	CYBB	IDA		Human	PMID:12042318
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	CYBB	IMP		Human	PMID:9774399
Molecular Function	GO:0020037	heme binding	CYBB	IMP		Human	PMID:9774399
Molecular Function	GO:0005515	protein binding	CYBB	IPI	UniProtKB:Q9BQA9	Human	PMID:28351984
Molecular Function	GO:0005515	protein binding	CYBB	IPI	UniProtKB:Q9BQA9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CYBB	IPI	UniProtKB:P13498	Human	PMID:3305576
Molecular Function	GO:0005515	protein binding	Cybb	IPI	UniProtKB:O70145	Mouse	MGI:MGI:5007562|PMID:21551061
Molecular Function	GO:0005515	protein binding	Cybb	IPI	UniProtKB:Q8BMT4	Mouse	MGI:MGI:5568138|PMID:24739962
Molecular Function	GO:0005515	protein binding	Cybb	IPI	UniProtKB:Q61462|UniProtKB:Q8BMT4	Mouse	MGI:MGI:5568138|PMID:24739962
Molecular Function	GO:0005515	protein binding	Cybb	IPI	RGD:620573	Rat	PMID:15322091|RGD:1580287
Molecular Function	GO:0005515	protein binding	Cybb	IPI	RGD:2070	Rat	PMID:21376054|RGD:5129173
Molecular Function	GO:0046982	protein heterodimerization activity	CYBB	IPI	UniProtKB:P13498	Human	PMID:12042318
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	CYBB	IDA		Human	PMID:12042318
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	Cybb	IDA		Mouse	PMID:22493499
Cellular Component	GO:0005737	cytoplasm	Cybb	IDA		Mouse	MGI:MGI:5468041|PMID:23303671
Cellular Component	GO:0005737	cytoplasm	Cybb	IDA		Mouse	PMID:15499027
Cellular Component	GO:0005737	cytoplasm	Cybb	IDA		Mouse	PMID:15850784
Cellular Component	GO:0030425	dendrite	Cybb	IDA		Rat	PMID:17027166|RGD:1599676
Cellular Component	GO:0005783	endoplasmic reticulum	Cybb	IDA		Rat	PMID:17027166|RGD:1599676
Cellular Component	GO:0005794	Golgi apparatus	Cybb	IDA		Rat	PMID:17027166|RGD:1599676
Cellular Component	GO:0005739	mitochondrion	Cybb	HDA		Mouse	PMID:14651853
Cellular Component	GO:0043020	NADPH oxidase complex	CYBB	IDA		Human	PMID:3305576
Cellular Component	GO:0043020	NADPH oxidase complex	Cybb	IDA		Mouse	MGI:MGI:5568138|PMID:24739962
Cellular Component	GO:0043020	NADPH oxidase complex	Cybb	IDA		Rat	PMID:12241540|RGD:2291907
Cellular Component	GO:0043020	NADPH oxidase complex	Cybb	IDA		Rat	PMID:15322091|RGD:1580287
Cellular Component	GO:0043025	neuronal cell body	Cybb	IDA		Rat	PMID:17027166|RGD:1599676
Cellular Component	GO:0005635	nuclear envelope	Cybb	IDA		Rat	PMID:21691064|RGD:11040687
Cellular Component	GO:0097038	perinuclear endoplasmic reticulum	Cybb	IDA		Rat	PMID:10938010|RGD:632513
Cellular Component	GO:0045335	phagocytic vesicle	Cybb	IDA		Mouse	MGI:MGI:5468041|PMID:23303671
Cellular Component	GO:0005886	plasma membrane	CYBB	IDA		Human	PMID:15233623
Cellular Component	GO:0005886	plasma membrane	Cybb	IDA		Mouse	PMID:15499027
Cellular Component	GO:0005886	plasma membrane	Cybb	IDA		Rat	PMID:17027166|RGD:1599676
Cellular Component	GO:0005791	rough endoplasmic reticulum	Cybb	IDA		Rat	PMID:17027166|RGD:1599676
Biological Process	GO:0071276	cellular response to cadmium ion	Cybb	IEP		Rat	PMID:21195169|RGD:11040689
Biological Process	GO:0071361	cellular response to ethanol	Cybb	IEP		Rat	PMID:26079697|RGD:11040765
Biological Process	GO:0071456	cellular response to hypoxia	Cybb	IEP		Rat	PMID:21302291|RGD:11040609
Biological Process	GO:1904845	cellular response to L-glutamine	Cybb	IEP		Rat	PMID:12241540|RGD:2291907
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	Cybb	IMP	MGI:MGI:1857284	Mouse	PMID:15258578
Biological Process	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway	Cybb	IMP		Rat	PMID:21302291|RGD:11040609
Biological Process	GO:0006954	inflammatory response	Cybb	IMP		Mouse	MGI:MGI:5568138|PMID:24739962
Biological Process	GO:0045087	innate immune response	CYBB	IMP		Human	PMID:9774399
Biological Process	GO:0045087	innate immune response	Cybb	IMP		Mouse	MGI:MGI:5901952|PMID:28351984
Biological Process	GO:0045766	positive regulation of angiogenesis	Cybb	IMP		Rat	PMID:24633549|RGD:11040763
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Cybb	IMP		Rat	PMID:19318376|RGD:11040691
Biological Process	GO:0045730	respiratory burst	CYBB	IMP		Human	PMID:9774399
Biological Process	GO:1904044	response to aldosterone	Cybb	IEP		Rat	PMID:21824999|RGD:11040695
Biological Process	GO:1990776	response to angiotensin	Cybb	IEP		Rat	PMID:11884382|RGD:11040630
Biological Process	GO:0007584	response to nutrient	Cybb	IEP		Rat	PMID:16784966|RGD:1599678
Biological Process	GO:0009410	response to xenobiotic stimulus	Cybb	IDA		Rat	PMID:16766636|RGD:1599677
Biological Process	GO:0042554	superoxide anion generation	CYBB	IDA		Human	PMID:12042318
Biological Process	GO:0006801	superoxide metabolic process	CYBB	IDA		Human	PMID:12042318
Biological Process	GO:0006801	superoxide metabolic process	Cybb	IMP		Mouse	MGI:MGI:5568138|PMID:24739962

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern