Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYCS
  • Mouse genes Cycs
  • Rat genes Cycs,Cycs-ps9,LOC690675,RGD1562558
  • Zfish genes cycsa,cycsb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cycs

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	Cycs	IDA		Rat	PMID:7918531|RGD:11565847
Molecular Function	GO:0020037	heme binding	Cycs	IDA		Mouse	PMID:16757556
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:O14727	Human	PMID:10206961
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q9FKS5	Human	PMID:25595453
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q6A162	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:A0A0A0MR05	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:O00303	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:O43829	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:P06241	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:P37840	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q13573	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q1L5Z9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q3SXR2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q3SYB3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q66K80	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q6XD76	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q6ZMI0-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q8IYG6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q8IZU1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q8N5Z5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q92797-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q96BR5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q9BUL5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q9NSI6-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q9NTN9-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:Q9UKG9-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYCS	IPI	UniProtKB:O14727	Human	PMID:9267021
Cellular Component	GO:0043293	apoptosome	CYCS	IPI		Human	PMID:10206961
Cellular Component	GO:0005829	cytosol	CYCS	IDA		Human	PMID:12107093
Cellular Component	GO:0005829	cytosol	CYCS	IMP		Human	PMID:8689682
Cellular Component	GO:0005829	cytosol	Cycs	IDA		Mouse	PMID:16469926
Cellular Component	GO:0005829	cytosol	Cycs	IDA		Mouse	PMID:14657025
Cellular Component	GO:0005829	cytosol	Cycs	IDA		Mouse	PMID:15271982
Cellular Component	GO:0005829	cytosol	Cycs-ps9	IDA		Rat	PMID:17571083|RGD:10047203
Cellular Component	GO:0005829	cytosol	Cycs	IDA		Rat	PMID:17571083|RGD:10047203
Cellular Component	GO:0005829	cytosol	Cycs	IDA		Rat	PMID:18485100|RGD:2314399
Cellular Component	GO:0005829	cytosol	Cycs	IDA		Rat	PMID:18817839|RGD:2313963
Cellular Component	GO:0005758	mitochondrial intermembrane space	CYCS	IDA		Human	PMID:19393246
Cellular Component	GO:0005739	mitochondrion	CYCS	IDA		Human	PMID:12107093
Cellular Component	GO:0005739	mitochondrion	CYCS	IDA		Human	PMID:20671748
Cellular Component	GO:0005739	mitochondrion	CYCS	HDA		Human	PMID:20833797
Cellular Component	GO:0005739	mitochondrion	Cycs	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Cycs	IDA		Mouse	PMID:16469926
Cellular Component	GO:0005739	mitochondrion	Cycs	IDA		Mouse	PMID:14657025
Cellular Component	GO:0005739	mitochondrion	Cycs	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Cycs	IDA		Mouse	PMID:16103131
Cellular Component	GO:0005739	mitochondrion	Cycs	IDA		Mouse	PMID:14623868
Cellular Component	GO:0005739	mitochondrion	Cycs	IDA		Rat	PMID:10980192|RGD:2300408
Cellular Component	GO:0005739	mitochondrion	Cycs	IDA		Rat	PMID:11027612|RGD:2300405
Cellular Component	GO:0005739	mitochondrion	Cycs	IDA		Rat	PMID:11818574|RGD:70241
Cellular Component	GO:0005739	mitochondrion	Cycs	IDA		Rat	PMID:18252800|RGD:2313987
Cellular Component	GO:0005739	mitochondrion	Cycs	IDA		Rat	PMID:18485100|RGD:2314399
Cellular Component	GO:0043209	myelin sheath	Cycs	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005634	nucleus	CYCS	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005634	nucleus	CYCS	HDA		Human	PMID:21630459
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	CYCS	IDA		Human	PMID:10206961
Biological Process	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	CYCS	IDA		Human	PMID:10206961
Biological Process	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	Cycs	IMP	MGI:MGI:3581449	Mouse	PMID:15907471
Biological Process	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	Cycs	IMP	MGI:MGI:2154447	Mouse	PMID:10830166
Biological Process	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	Cycs	IMP		Mouse	PMID:14623868
Biological Process	GO:0006915	apoptotic process	Cycs	IDA		Mouse	PMID:16757556
Biological Process	GO:0006915	apoptotic process	Cycs	IMP		Rat	PMID:18817839|RGD:2313963
Biological Process	GO:0034349	glial cell apoptotic process	Cycs	IEP		Rat	PMID:18931364|RGD:2313998
Biological Process	GO:0042743	hydrogen peroxide metabolic process	Cycs	IDA		Mouse	PMID:16757556
Biological Process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	Cycs	IMP		Rat	PMID:10980192|RGD:2300408
Biological Process	GO:0010730	negative regulation of hydrogen peroxide biosynthetic process	Cycs	IMP		Rat	PMID:21410437|RGD:7349317
Biological Process	GO:1901857	positive regulation of cellular respiration	Cycs	IMP		Rat	PMID:21410437|RGD:7349317
Biological Process	GO:0043393	regulation of protein binding	Cycs	IMP	MGI:MGI:2154447	Mouse	PMID:10830166
Biological Process	GO:0034465	response to carbon monoxide	Cycs	IEP		Rat	PMID:6317876|RGD:11352705
Biological Process	GO:0046688	response to copper ion	Cycs	IEP		Rat	PMID:14608045|RGD:11352711
Biological Process	GO:0009629	response to gravity	Cycs	IEP		Rat	PMID:25928980|RGD:11352708
Biological Process	GO:0002931	response to ischemia	Cycs	IDA		Rat	PMID:21410437|RGD:7349317
Biological Process	GO:0006979	response to oxidative stress	Cycs	IEP		Rat	PMID:11818574|RGD:70241

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern