Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYFIP2
  • Mouse genes Cyfip2
  • Rat genes Cyfip2
  • Zfish genes cyfip2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyfip2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CYFIP2	IPI	UniProtKB:Q06787	Human	PMID:11438699
Molecular Function	GO:0005515	protein binding	CYFIP2	IPI	UniProtKB:P63000	Human	PMID:15048733
Molecular Function	GO:0005515	protein binding	CYFIP2	IPI	UniProtKB:Q06787	Human	PMID:24658146
Molecular Function	GO:0005515	protein binding	Cyfip2	IPI	UniProtKB:P35922|UniProtKB:Q61584|UniProtKB:Q9WVR4	Mouse	MGI:MGI:3036554|PMID:11438699
Molecular Function	GO:0005515	protein binding	Cyfip2	IPI	UniProtKB:Q4ACU6	Mouse	MGI:MGI:6092779|PMID:28671696
Molecular Function	GO:0005515	protein binding	Cyfip2	IPI	UniProtKB:Q8BHE4	Mouse	MGI:MGI:5825407|PMID:27605705
Cellular Component	GO:0005737	cytoplasm	CYFIP2	IDA		Human	PMID:11438699
Cellular Component	GO:0070062	extracellular exosome	CYFIP2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CYFIP2	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	CYFIP2	HDA		Human	PMID:23533145
Cellular Component	GO:0016020	membrane	CYFIP2	HDA		Human	PMID:19946888
Cellular Component	GO:0048471	perinuclear region of cytoplasm	CYFIP2	IDA		Human	PMID:10449408
Cellular Component	GO:0031209	SCAR complex	CYFIP2	IDA		Human	PMID:17101133
Cellular Component	GO:0031209	SCAR complex	CYFIP2	IDA		Human	PMID:26428302
Cellular Component	GO:0031209	SCAR complex	Cyfip2	IDA		Mouse	MGI:MGI:6508508|PMID:26428302
Cellular Component	GO:0045202	synapse	CYFIP2	IDA		Human	PMID:11438699
Cellular Component	GO:0045202	synapse	Cyfip2	IEP		Mouse	PMID:11438699
Cellular Component	GO:0045202	synapse	Cyfip2	IDA		Mouse	PMID:11438699
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	CYFIP2	IDA		Human	PMID:18387192
Biological Process	GO:0006915	apoptotic process	CYFIP2	IDA		Human	PMID:10449408
Biological Process	GO:0098609	cell-cell adhesion	CYFIP2	IDA		Human	PMID:15048733
Biological Process	GO:0097484	dendrite extension	Cyfip2	IMP		Mouse	MGI:MGI:5825407|PMID:27605705
Biological Process	GO:0031175	neuron projection development	Cyfip2	IMP		Mouse	MGI:MGI:5825407|PMID:27605705
Biological Process	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway	Cyfip2	IMP		Mouse	MGI:MGI:5825407|PMID:27605705
Biological Process	GO:0045862	positive regulation of proteolysis	CYFIP2	IDA		Human	PMID:18387192
Biological Process	GO:0010842	retina layer formation	cyfip2	IMP	ZFIN:ZDB-GENO-100908-3	Zfish	PMID:20537992
Biological Process	GO:0031290	retinal ganglion cell axon guidance	cyfip2	IMP	ZFIN:ZDB-CRISPR-191120-5	Zfish	PMID:29518358
Biological Process	GO:0031290	retinal ganglion cell axon guidance	cyfip2	IMP	ZFIN:ZDB-GENO-980202-978	Zfish	PMID:20537992
Biological Process	GO:0001964	startle response	cyfip2	IMP	ZFIN:ZDB-GENO-180827-2	Zfish	PMID:29669291

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern