Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Cyp11a1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CYP11A1
- Mouse genes Cyp11a1
- Rat genes Cyp11a1
- Zfish genes cyp11a1.1,cyp11a1.2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp11a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015485	cholesterol binding	Cyp11a1	IMP		Rat	PMID:16226009\|RGD:1599700
Molecular Function	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	CYP11A1	IDA		Human	PMID:11502818
Molecular Function	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	CYP11A1	IDA		Human	PMID:18182448
Molecular Function	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	CYP11A1	IDA		Human	PMID:21636783
Molecular Function	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	Cyp11a1	IDA		Mouse	PMID:7527351
Molecular Function	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	Cyp11a1	IMP		Rat	PMID:16226009\|RGD:1599700
Molecular Function	GO:0020037	heme binding	CYP11A1	IDA		Human	PMID:21636783
Molecular Function	GO:0005515	protein binding	CYP11A1	IPI	UniProtKB:Q9NZ94-2	Human	PMID:25464930
Cellular Component	GO:0030061	mitochondrial crista	Cyp11a1	IDA		Rat	PMID:11691658\|RGD:1599714
Cellular Component	GO:0005743	mitochondrial inner membrane	Cyp11a1	IDA		Rat	PMID:21075169\|RGD:4420111
Cellular Component	GO:0005739	mitochondrion	Cyp11a1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Cyp11a1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Cyp11a1	IDA		Mouse	PMID:8111631
Cellular Component	GO:0005739	mitochondrion	Cyp11a1	IDA		Rat	PMID:2170421\|RGD:13506267
Cellular Component	GO:0005739	mitochondrion	Cyp11a1	IDA		Rat	PMID:8674848\|RGD:1624285
Cellular Component	GO:0043204	perikaryon	Cyp11a1	IDA		Rat	PMID:16632873\|RGD:4889134
Biological Process	GO:0018879	biphenyl metabolic process	Cyp11a1	IEP		Rat	PMID:19071209\|RGD:4768197
Biological Process	GO:0018879	biphenyl metabolic process	Cyp11a1	IEP		Rat	PMID:20356859\|RGD:4448154
Biological Process	GO:0006700	C21-steroid hormone biosynthetic process	CYP11A1	IDA		Human	PMID:11502818
Biological Process	GO:0006700	C21-steroid hormone biosynthetic process	CYP11A1	IDA		Human	PMID:18182448
Biological Process	GO:0006700	C21-steroid hormone biosynthetic process	CYP11A1	IDA		Human	PMID:21636783
Biological Process	GO:0006700	C21-steroid hormone biosynthetic process	Cyp11a1	IDA		Mouse	PMID:7527351
Biological Process	GO:0006700	C21-steroid hormone biosynthetic process	Cyp11a1	IDA		Rat	PMID:19665544\|RGD:4891164
Biological Process	GO:0006700	C21-steroid hormone biosynthetic process	cyp11a1.1	IMP	ZFIN:ZDB-MRPHLNO-060301-3	Zfish	PMID:16437115
Biological Process	GO:0071236	cellular response to antibiotic	Cyp11a1	IEP		Rat	PMID:18655822\|RGD:4777466
Biological Process	GO:0071276	cellular response to cadmium ion	Cyp11a1	IEP		Rat	PMID:17719163\|RGD:4835171
Biological Process	GO:0071320	cellular response to cAMP	Cyp11a1	IEP		Rat	PMID:17719163\|RGD:4835171
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	Cyp11a1	IEP		Rat	PMID:17494997\|RGD:2289861
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	Cyp11a1	IEP		Rat	PMID:20810564\|RGD:4145531
Biological Process	GO:0071371	cellular response to gonadotropin stimulus	Cyp11a1	IEP		Rat	PMID:9397943\|RGD:4891988
Biological Process	GO:0071347	cellular response to interleukin-1	Cyp11a1	IEP		Rat	PMID:9397943\|RGD:4891988
Biological Process	GO:0071347	cellular response to interleukin-1	Cyp11a1	IEP		Rat	PMID:9582502\|RGD:4891986
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Cyp11a1	IEP		Rat	PMID:20665543\|RGD:4145535
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	Cyp11a1	IEP		Rat	PMID:19416745\|RGD:4145628
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Cyp11a1	IEP		Rat	PMID:18511507\|RGD:4781450
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Cyp11a1	IEP		Rat	PMID:9397943\|RGD:4891988
Biological Process	GO:0021549	cerebellum development	Cyp11a1	IEP		Rat	PMID:16329132\|RGD:1599699
Biological Process	GO:0008203	cholesterol metabolic process	CYP11A1	IMP		Human	PMID:18182448
Biological Process	GO:0008203	cholesterol metabolic process	CYP11A1	IDA		Human	PMID:21636783
Biological Process	GO:0034651	cortisol biosynthetic process	cyp11a1.2	IMP	ZFIN:ZDB-MRPHLNO-130911-6	Zfish	PMID:23671259
Biological Process	GO:0061371	determination of heart left/right asymmetry	cyp11a1.1	IMP	ZFIN:ZDB-MRPHLNO-191114-3	Zfish	PMID:31075101
Biological Process	GO:0018894	dibenzo-p-dioxin metabolic process	Cyp11a1	IEP		Rat	PMID:18637154\|RGD:4778755
Biological Process	GO:0090504	epiboly	cyp11a1.1	IMP	ZFIN:ZDB-MRPHLNO-060301-3	Zfish	PMID:23671259
Biological Process	GO:0060014	granulosa cell differentiation	Cyp11a1	IEP		Rat	PMID:2176216\|RGD:632561
Biological Process	GO:0021766	hippocampus development	Cyp11a1	IEP		Rat	PMID:21047951\|RGD:4145527
Biological Process	GO:0033327	Leydig cell differentiation	Cyp11a1	IEP		Rat	PMID:18502897\|RGD:4781870
Biological Process	GO:0008584	male gonad development	Cyp11a1	IEP		Rat	PMID:18772241\|RGD:2303053
Biological Process	GO:0060135	maternal process involved in female pregnancy	Cyp11a1	IEP		Rat	PMID:17726144\|RGD:4833999
Biological Process	GO:0007617	mating behavior	Cyp11a1	IMP		Rat	PMID:16101892\|RGD:1599706
Biological Process	GO:0006082	organic acid metabolic process	Cyp11a1	IEP		Rat	PMID:17400581\|RGD:4889129
Biological Process	GO:0018958	phenol-containing compound metabolic process	Cyp11a1	IEP		Rat	PMID:18191889\|RGD:4831838
Biological Process	GO:0018963	phthalate metabolic process	Cyp11a1	IEP		Rat	PMID:18923996\|RGD:2317622
Biological Process	GO:0031116	positive regulation of microtubule polymerization	cyp11a1.1	IMP	ZFIN:ZDB-MRPHLNO-060301-3	Zfish	PMID:23955365
Biological Process	GO:0031116	positive regulation of microtubule polymerization	cyp11a1.1	IMP	ZFIN:ZDB-MRPHLNO-060301-3	Zfish	PMID:16437115
Biological Process	GO:0031116	positive regulation of microtubule polymerization	cyp11a1.1	IGI	ZFIN:ZDB-MRPHLNO-060301-3,ZFIN:ZDB-MRPHLNO-131112-1	Zfish	PMID:23955365
Biological Process	GO:0090031	positive regulation of steroid hormone biosynthetic process	cyp11a1.2	IMP	ZFIN:ZDB-GENO-220503-1	Zfish	PMID:31693487
Biological Process	GO:0043279	response to alkaloid	Cyp11a1	IEP		Rat	PMID:18772241\|RGD:2303053
Biological Process	GO:0043200	response to amino acid	Cyp11a1	IEP		Rat	PMID:18040670\|RGD:4831841
Biological Process	GO:0046677	response to antibiotic	Cyp11a1	IEP		Rat	PMID:19118620\|RGD:4763313
Biological Process	GO:0046686	response to cadmium ion	Cyp11a1	IEP		Rat	PMID:15223132\|RGD:1599710
Biological Process	GO:0051591	response to cAMP	Cyp11a1	IEP		Rat	PMID:2176216\|RGD:632561
Biological Process	GO:0051412	response to corticosterone	Cyp11a1	IEP		Rat	PMID:18335507\|RGD:4831835
Biological Process	GO:0043627	response to estrogen	Cyp11a1	IEP		Rat	PMID:12715917\|RGD:1599712
Biological Process	GO:0043627	response to estrogen	Cyp11a1	IEP		Rat	PMID:19734697\|RGD:4145613
Biological Process	GO:0060992	response to fungicide	Cyp11a1	IEP		Rat	PMID:14967917\|RGD:4891062
Biological Process	GO:0010332	response to gamma radiation	Cyp11a1	IEP		Rat	PMID:18046538\|RGD:4831839
Biological Process	GO:0033595	response to genistein	Cyp11a1	IEP		Rat	PMID:16214947\|RGD:4889136
Biological Process	GO:0034698	response to gonadotropin	Cyp11a1	IEP		Rat	PMID:19929576\|RGD:4145607
Biological Process	GO:0042542	response to hydrogen peroxide	Cyp11a1	IMP		Rat	PMID:14635199\|RGD:1599711
Biological Process	GO:0017085	response to insecticide	Cyp11a1	IEP		Rat	PMID:19892000\|RGD:4145608
Biological Process	GO:0010212	response to ionizing radiation	Cyp11a1	IEP		Rat	PMID:18821396\|RGD:4770368
Biological Process	GO:0033591	response to L-ascorbic acid	Cyp11a1	IEP		Rat	PMID:17280759\|RGD:4891016
Biological Process	GO:0007584	response to nutrient	Cyp11a1	IEP		Rat	PMID:16844298\|RGD:1599695
Biological Process	GO:0014070	response to organic cyclic compound	Cyp11a1	IEP		Rat	PMID:18606229\|RGD:4781442
Biological Process	GO:0014070	response to organic cyclic compound	Cyp11a1	IEP		Rat	PMID:22777679\|RGD:151893504
Biological Process	GO:0014070	response to organic cyclic compound	Cyp11a1	IEP		Rat	PMID:28208728\|RGD:151893505
Biological Process	GO:0010033	response to organic substance	Cyp11a1	IEP		Rat	PMID:16226009\|RGD:1599700
Biological Process	GO:0010033	response to organic substance	Cyp11a1	IEP		Rat	PMID:18804513\|RGD:4772578
Biological Process	GO:0043434	response to peptide hormone	Cyp11a1	IEP		Rat	PMID:18609294\|RGD:4781133
Biological Process	GO:0009651	response to salt stress	Cyp11a1	IEP		Rat	PMID:7678819\|RGD:4391949
Biological Process	GO:0048545	response to steroid hormone	Cyp11a1	IEP		Rat	PMID:19961867\|RGD:4145605
Biological Process	GO:0048545	response to steroid hormone	cyp11a1.1	IEP		Zfish	PMID:28265462
Biological Process	GO:0033197	response to vitamin E	Cyp11a1	IEP		Rat	PMID:17280759\|RGD:4891016
Biological Process	GO:0009410	response to xenobiotic stimulus	Cyp11a1	IEP		Rat	PMID:20144211\|RGD:4145598
Biological Process	GO:0014037	Schwann cell differentiation	Cyp11a1	IEP		Rat	PMID:18373277\|RGD:4784823
Biological Process	GO:0007283	spermatogenesis	cyp11a1.2	IMP	ZFIN:ZDB-GENO-220503-1	Zfish	PMID:31693487
Biological Process	GO:0006694	steroid biosynthetic process	Cyp11a1	IMP		Rat	PMID:16226009\|RGD:1599700
Biological Process	GO:0006694	steroid biosynthetic process	Cyp11a1	IMP		Rat	PMID:17218406\|RGD:1624270
Biological Process	GO:0006694	steroid biosynthetic process	cyp11a1.2	IMP	ZFIN:ZDB-MRPHLNO-130911-6	Zfish	PMID:23671259
Biological Process	GO:0061370	testosterone biosynthetic process	Cyp11a1	IEP		Rat	PMID:19883722\|RGD:4145609

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.