Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP11B1,CYP11B2
  • Mouse genes Cyp11b1
  • Rat genes Cyp11b1
  • Zfish genes cyp11c1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp11b1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047783	corticosterone 18-monooxygenase activity	Cyp11b1	IDA		Mouse	PMID:1686470
Molecular Function	GO:0047783	corticosterone 18-monooxygenase activity	Cyp11b1	IDA		Mouse	PMID:8645611
Molecular Function	GO:0020037	heme binding	CYP11B2	IDA		Human	PMID:23322723
Molecular Function	GO:0004507	steroid 11-beta-monooxygenase activity	CYP11B1	IMP		Human	PMID:2022736
Molecular Function	GO:0004507	steroid 11-beta-monooxygenase activity	CYP11B1	IDA		Human	PMID:2256920
Molecular Function	GO:0004507	steroid 11-beta-monooxygenase activity	CYP11B1	IDA		Human	PMID:8506298
Molecular Function	GO:0004507	steroid 11-beta-monooxygenase activity	CYP11B2	IDA		Human	PMID:1741400
Molecular Function	GO:0004507	steroid 11-beta-monooxygenase activity	CYP11B2	IDA		Human	PMID:2256920
Molecular Function	GO:0004507	steroid 11-beta-monooxygenase activity	CYP11B2	IDA		Human	PMID:23322723
Molecular Function	GO:0004507	steroid 11-beta-monooxygenase activity	Cyp11b1	IDA		Rat	PMID:16405651|RGD:1624284
Molecular Function	GO:0005496	steroid binding	Cyp11b1	IDA		Rat	PMID:16405651|RGD:1624284
Cellular Component	GO:0005739	mitochondrion	CYP11B1	IDA		Human	PMID:2256920
Cellular Component	GO:0005739	mitochondrion	CYP11B2	IDA		Human	PMID:1741400
Cellular Component	GO:0005739	mitochondrion	CYP11B2	IDA		Human	PMID:2256920
Cellular Component	GO:0005739	mitochondrion	Cyp11b1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Cyp11b1	IDA		Mouse	PMID:10224232
Cellular Component	GO:0005739	mitochondrion	Cyp11b1	IDA		Rat	PMID:8674848|RGD:1624285
Biological Process	GO:0046085	adenosine metabolic process	Cyp11b1	IEP		Rat	PMID:20937274|RGD:4145529
Biological Process	GO:0032342	aldosterone biosynthetic process	CYP11B1	IMP		Human	PMID:19342457
Biological Process	GO:0032342	aldosterone biosynthetic process	CYP11B1	IDA		Human	PMID:2256920
Biological Process	GO:0032342	aldosterone biosynthetic process	CYP11B2	IDA		Human	PMID:1741400
Biological Process	GO:0032342	aldosterone biosynthetic process	CYP11B2	IMP		Human	PMID:19342457
Biological Process	GO:0032342	aldosterone biosynthetic process	CYP11B2	IDA		Human	PMID:2256920
Biological Process	GO:0032342	aldosterone biosynthetic process	CYP11B2	IDA		Human	PMID:23322723
Biological Process	GO:0032342	aldosterone biosynthetic process	Cyp11b1	IMP		Rat	PMID:19342457|RGD:4891166
Biological Process	GO:0006700	C21-steroid hormone biosynthetic process	CYP11B1	IDA		Human	PMID:2256920
Biological Process	GO:0006700	C21-steroid hormone biosynthetic process	CYP11B2	IDA		Human	PMID:2256920
Biological Process	GO:0032870	cellular response to hormone stimulus	CYP11B1	IEP		Human	PMID:19342457
Biological Process	GO:0032870	cellular response to hormone stimulus	CYP11B2	IEP		Human	PMID:19342457
Biological Process	GO:0035865	cellular response to potassium ion	CYP11B1	IEP		Human	PMID:19342457
Biological Process	GO:0035865	cellular response to potassium ion	CYP11B2	IEP		Human	PMID:19342457
Biological Process	GO:0071346	cellular response to type II interferon	Cyp11b1	IEP		Rat	PMID:12121434|RGD:632369
Biological Process	GO:0034651	cortisol biosynthetic process	CYP11B1	IMP		Human	PMID:19342457
Biological Process	GO:0034651	cortisol biosynthetic process	CYP11B1	IMP		Human	PMID:2022736
Biological Process	GO:0034651	cortisol biosynthetic process	CYP11B1	IDA		Human	PMID:8506298
Biological Process	GO:0034651	cortisol biosynthetic process	CYP11B2	IMP		Human	PMID:19342457
Biological Process	GO:0034651	cortisol biosynthetic process	Cyp11b1	IMP		Rat	PMID:19342457|RGD:4891166
Biological Process	GO:0034650	cortisol metabolic process	cyp11c1	IMP	ZFIN:ZDB-MRPHLNO-140414-1	Zfish	PMID:24167225
Biological Process	GO:0018894	dibenzo-p-dioxin metabolic process	Cyp11b1	IEP		Rat	PMID:16254025|RGD:4889135
Biological Process	GO:0006704	glucocorticoid biosynthetic process	Cyp11b1	IDA		Mouse	PMID:8645611
Biological Process	GO:0006704	glucocorticoid biosynthetic process	Cyp11b1	IMP		Mouse	PMID:10224232
Biological Process	GO:0006704	glucocorticoid biosynthetic process	Cyp11b1	IDA		Mouse	PMID:1686470
Biological Process	GO:0006704	glucocorticoid biosynthetic process	Cyp11b1	IDA		Rat	PMID:19665544|RGD:4891164
Biological Process	GO:0008584	male gonad development	cyp11c1	IMP	ZFIN:ZDB-GENO-210923-11	Zfish	PMID:32222764
Biological Process	GO:0007617	mating behavior	cyp11c1	IMP	ZFIN:ZDB-GENO-210923-11	Zfish	PMID:32222764
Biological Process	GO:0055075	potassium ion homeostasis	CYP11B2	IMP		Human	PMID:9838244
Biological Process	GO:0008217	regulation of blood pressure	CYP11B1	IMP		Human	PMID:2022736
Biological Process	GO:0002017	regulation of blood volume by renal aldosterone	CYP11B2	IMP		Human	PMID:14614232
Biological Process	GO:0071548	response to dexamethasone	Cyp11b1	IEP		Rat	PMID:18252953|RGD:2307305
Biological Process	GO:0009410	response to xenobiotic stimulus	Cyp11b1	IEP		Rat	PMID:19733641|RGD:4460910
Biological Process	GO:0055078	sodium ion homeostasis	CYP11B2	IMP		Human	PMID:9838244
Biological Process	GO:0006694	steroid biosynthetic process	Cyp11b1	IDA		Rat	PMID:16405651|RGD:1624284

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern