Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP17A1
  • Mouse genes Cyp17a1
  • Rat genes Cyp17a1
  • Zfish genes cyp17a1,cyp17a2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp17a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	cyp17a1	IDA		Zfish	PMID:25533464
Molecular Function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	CYP17A1	IMP		Human	PMID:24140098
Molecular Function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	cyp17a1	IDA		Zfish	PMID:25533464
Molecular Function	GO:0020037	heme binding	CYP17A1	IDA		Human	PMID:22266943
Molecular Function	GO:0004508	steroid 17-alpha-monooxygenase activity	CYP17A1	IMP		Human	PMID:22170710
Molecular Function	GO:0004508	steroid 17-alpha-monooxygenase activity	CYP17A1	IDA		Human	PMID:22266943
Molecular Function	GO:0004508	steroid 17-alpha-monooxygenase activity	CYP17A1	IMP		Human	PMID:24140098
Molecular Function	GO:0004508	steroid 17-alpha-monooxygenase activity	Cyp17a1	IDA		Mouse	PMID:7588219
Molecular Function	GO:0004508	steroid 17-alpha-monooxygenase activity	Cyp17a1	IMP	MGI:MGI:3047328	Mouse	PMID:15169901
Molecular Function	GO:0004508	steroid 17-alpha-monooxygenase activity	Cyp17a1	IDA		Rat	PMID:2786990|RGD:1298835
Molecular Function	GO:0004508	steroid 17-alpha-monooxygenase activity	cyp17a1	IDA		Zfish	PMID:25533464
Molecular Function	GO:0004508	steroid 17-alpha-monooxygenase activity	cyp17a2	IDA		Zfish	PMID:25533464
Cellular Component	GO:0030424	axon	Cyp17a1	IDA		Mouse	PMID:7588260
Cellular Component	GO:0042995	cell projection	Cyp17a1	IDA		Rat	PMID:15934942|RGD:4889140
Cellular Component	GO:0005783	endoplasmic reticulum	Cyp17a1	IDA		Rat	PMID:11691658|RGD:1599714
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Cyp17a1	IDA		Rat	PMID:17936465|RGD:4889109
Cellular Component	GO:0005739	mitochondrion	Cyp17a1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0043025	neuronal cell body	Cyp17a1	IDA		Mouse	PMID:7588260
Cellular Component	GO:0043025	neuronal cell body	Cyp17a1	IDA		Rat	PMID:15934942|RGD:4889140
Biological Process	GO:0030325	adrenal gland development	Cyp17a1	IEP		Rat	PMID:17065412|RGD:4889133
Biological Process	GO:1903449	androst-4-ene-3,17-dione biosynthetic process	cyp17a1	IDA		Zfish	PMID:25533464
Biological Process	GO:0018879	biphenyl metabolic process	Cyp17a1	IEP		Rat	PMID:20356859|RGD:4448154
Biological Process	GO:0071236	cellular response to antibiotic	Cyp17a1	IEP		Rat	PMID:18655822|RGD:4777466
Biological Process	GO:0071371	cellular response to gonadotropin stimulus	Cyp17a1	IEP		Rat	PMID:20963569|RGD:4842495
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Cyp17a1	IEP		Rat	PMID:20665543|RGD:4145535
Biological Process	GO:0018894	dibenzo-p-dioxin metabolic process	Cyp17a1	IEP		Rat	PMID:20059580|RGD:2324640
Biological Process	GO:0030237	female sex determination	cyp17a1	IGI	ZFIN:ZDB-GENE-040806-1	Zfish	PMID:30202919
Biological Process	GO:0030237	female sex determination	cyp17a1	IMP	ZFIN:ZDB-GENO-191029-6	Zfish	PMID:30202919
Biological Process	GO:0006704	glucocorticoid biosynthetic process	Cyp17a1	IDA		Mouse	PMID:7588219
Biological Process	GO:0021766	hippocampus development	Cyp17a1	IEP		Rat	PMID:21047951|RGD:4145527
Biological Process	GO:0042446	hormone biosynthetic process	CYP17A1	IDA		Human	PMID:22266943
Biological Process	GO:0033327	Leydig cell differentiation	Cyp17a1	IEP		Rat	PMID:18502897|RGD:4781870
Biological Process	GO:0008584	male gonad development	Cyp17a1	IEP		Rat	PMID:10822021|RGD:4889557
Biological Process	GO:0030238	male sex determination	cyp17a1	IMP	ZFIN:ZDB-GENO-191029-6	Zfish	PMID:30202919
Biological Process	GO:0030238	male sex determination	cyp17a1	IGI	ZFIN:ZDB-GENE-040806-1	Zfish	PMID:30202919
Biological Process	GO:0006082	organic acid metabolic process	Cyp17a1	IEP		Rat	PMID:17400581|RGD:4889129
Biological Process	GO:0030728	ovulation	Cyp17a1	IEP		Rat	PMID:19775733|RGD:4888508
Biological Process	GO:0018958	phenol-containing compound metabolic process	Cyp17a1	IEP		Rat	PMID:18191889|RGD:4831838
Biological Process	GO:0018963	phthalate metabolic process	Cyp17a1	IEP		Rat	PMID:16809437|RGD:1601046
Biological Process	GO:0090031	positive regulation of steroid hormone biosynthetic process	Cyp17a1	IMP		Rat	PMID:19615041|RGD:4888510
Biological Process	GO:0042448	progesterone metabolic process	CYP17A1	IDA		Human	PMID:22266943
Biological Process	GO:0042448	progesterone metabolic process	cyp17a1	IDA		Zfish	PMID:25533464
Biological Process	GO:0042448	progesterone metabolic process	cyp17a2	IDA		Zfish	PMID:25533464
Biological Process	GO:0010034	response to acetate	Cyp17a1	IEP		Rat	PMID:21046364|RGD:4842189
Biological Process	GO:0051591	response to cAMP	Cyp17a1	IEP		Rat	PMID:17291543|RGD:1624316
Biological Process	GO:0034097	response to cytokine	Cyp17a1	IEP		Rat	PMID:15958400|RGD:4889138
Biological Process	GO:0060992	response to fungicide	Cyp17a1	IEP		Rat	PMID:16214947|RGD:4889136
Biological Process	GO:0060992	response to fungicide	Cyp17a1	IEP		Rat	PMID:17369198|RGD:4889131
Biological Process	GO:0034698	response to gonadotropin	Cyp17a1	IEP		Rat	PMID:17291543|RGD:1624316
Biological Process	GO:0009635	response to herbicide	Cyp17a1	IEP		Rat	PMID:20667998|RGD:4145533
Biological Process	GO:0017085	response to insecticide	Cyp17a1	IEP		Rat	PMID:17569032|RGD:4835759
Biological Process	GO:0010212	response to ionizing radiation	Cyp17a1	IEP		Rat	PMID:18821396|RGD:4770368
Biological Process	GO:0051597	response to methylmercury	Cyp17a1	IEP		Rat	PMID:17869401|RGD:4889111
Biological Process	GO:0031667	response to nutrient levels	Cyp17a1	IEP		Rat	PMID:17936465|RGD:4889109
Biological Process	GO:0031667	response to nutrient levels	Cyp17a1	IEP		Rat	PMID:19389810|RGD:4476263
Biological Process	GO:0014070	response to organic cyclic compound	Cyp17a1	IEP		Rat	PMID:18923996|RGD:2317622
Biological Process	GO:0010033	response to organic substance	Cyp17a1	IEP		Rat	PMID:18804513|RGD:4772578
Biological Process	GO:0032526	response to retinoic acid	Cyp17a1	IEP		Rat	PMID:19497980|RGD:2317621
Biological Process	GO:0048545	response to steroid hormone	Cyp17a1	IEP		Rat	PMID:19961867|RGD:4145605
Biological Process	GO:0009636	response to toxic substance	Cyp17a1	IEP		Rat	PMID:17291543|RGD:1624316
Biological Process	GO:0009410	response to xenobiotic stimulus	Cyp17a1	IEP		Rat	PMID:19603415|RGD:4145625
Biological Process	GO:0006694	steroid biosynthetic process	Cyp17a1	IMP		Rat	PMID:2786990|RGD:1298835
Biological Process	GO:0008202	steroid metabolic process	CYP17A1	IDA		Human	PMID:22266943

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern