Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Cyp19a1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CYP19A1
- Mouse genes Cyp19a1
- Rat genes Cyp19a1
- Zfish genes cyp19a1a,cyp19a1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp19a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070330	aromatase activity	CYP19A1	IDA		Human	PMID:19129847
Molecular Function	GO:0070330	aromatase activity	CYP19A1	IDA		Human	PMID:26482249
Molecular Function	GO:0070330	aromatase activity	Cyp19a1	IDA		Rat	PMID:16269516\|RGD:1600845
Molecular Function	GO:0020037	heme binding	CYP19A1	IDA		Human	PMID:19129847
Molecular Function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Cyp19a1	IDA		Mouse	PMID:7669221
Molecular Function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Cyp19a1	IDA		Rat	PMID:11850226\|RGD:1298839
Cellular Component	GO:0043679	axon terminus	Cyp19a1	IDA		Rat	PMID:14694190\|RGD:1600839
Cellular Component	GO:0005737	cytoplasm	Cyp19a1	IDA		Rat	PMID:14694190\|RGD:1600839
Cellular Component	GO:0005829	cytosol	Cyp19a1	IDA		Rat	PMID:21114983\|RGD:4890041
Cellular Component	GO:0043197	dendritic spine	Cyp19a1	IDA		Rat	PMID:14694190\|RGD:1600839
Cellular Component	GO:0005783	endoplasmic reticulum	CYP19A1	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005783	endoplasmic reticulum	Cyp19a1	IDA		Rat	PMID:14694190\|RGD:1600839
Cellular Component	GO:0043025	neuronal cell body	Cyp19a1	IDA		Rat	PMID:19565659\|RGD:4890388
Cellular Component	GO:0045202	synapse	Cyp19a1	IDA		Rat	PMID:20926671\|RGD:4890044
Cellular Component	GO:0008021	synaptic vesicle	Cyp19a1	IDA		Rat	PMID:14694190\|RGD:1600839
Cellular Component	GO:0043195	terminal bouton	Cyp19a1	IDA		Rat	PMID:20926671\|RGD:4890044
Biological Process	GO:0030325	adrenal gland development	Cyp19a1	IEP		Rat	PMID:8097866\|RGD:4145970
Biological Process	GO:0006710	androgen catabolic process	CYP19A1	IDA		Human	PMID:26482249
Biological Process	GO:0008209	androgen metabolic process	Cyp19a1	IMP	MGI:MGI:2154536	Mouse	PMID:11356695
Biological Process	GO:0008209	androgen metabolic process	Cyp19a1	IMP		Rat	PMID:19492405\|RGD:4890392
Biological Process	GO:0008206	bile acid metabolic process	Cyp19a1	IEP		Rat	PMID:20026603\|RGD:4890374
Biological Process	GO:0018879	biphenyl metabolic process	Cyp19a1	IEP		Rat	PMID:19464308\|RGD:4890403
Biological Process	GO:0060348	bone development	Cyp19a1	IEP		Rat	PMID:15012600\|RGD:4891061
Biological Process	GO:0008207	C21-steroid hormone metabolic process	Cyp19a1	IDA		Rat	PMID:19190754\|RGD:4889515
Biological Process	GO:0097720	calcineurin-mediated signaling	Cyp19a1	IMP		Rat	PMID:25057110\|RGD:12904895
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	Cyp19a1	IEP		Rat	PMID:20434519\|RGD:4890357
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	Cyp19a1	IEP		Rat	PMID:20810564\|RGD:4145531
Biological Process	GO:0071333	cellular response to glucose stimulus	Cyp19a1	IEP		Rat	PMID:18353182\|RGD:4785271
Biological Process	GO:0071371	cellular response to gonadotropin stimulus	Cyp19a1	IEP		Rat	PMID:16569475\|RGD:4891019
Biological Process	GO:0071464	cellular response to hydrostatic pressure	Cyp19a1	IEP		Rat	PMID:21047944\|RGD:4890042
Biological Process	GO:0018894	dibenzo-p-dioxin metabolic process	Cyp19a1	IEP		Rat	PMID:20059580\|RGD:2324640
Biological Process	GO:0006703	estrogen biosynthetic process	Cyp19a1	IDA		Rat	PMID:19665544\|RGD:4891164
Biological Process	GO:0030540	female genitalia development	Cyp19a1	IMP	MGI:MGI:2154536	Mouse	PMID:9618522
Biological Process	GO:0019099	female germ-line sex determination	cyp19a1a	IMP	ZFIN:ZDB-GENO-180419-7	Zfish	PMID:28575219
Biological Process	GO:0008585	female gonad development	Cyp19a1	IMP	MGI:MGI:2154536	Mouse	PMID:9618522
Biological Process	GO:0008585	female gonad development	cyp19a1a	IMP	ZFIN:ZDB-GENO-170414-6	Zfish	PMID:32001440
Biological Process	GO:0008585	female gonad development	cyp19a1a	IMP	ZFIN:ZDB-GENO-170414-8	Zfish	PMID:27876832
Biological Process	GO:0008585	female gonad development	cyp19a1a	IMP	ZFIN:ZDB-GENO-170414-6	Zfish	PMID:27876832
Biological Process	GO:0008585	female gonad development	cyp19a1a	IMP	ZFIN:ZDB-GENO-170414-7	Zfish	PMID:27876832
Biological Process	GO:0030237	female sex determination	cyp19a1a	IMP	ZFIN:ZDB-MRPHLNO-170428-4	Zfish	PMID:28203731
Biological Process	GO:0046660	female sex differentiation	cyp19a1a	IMP	ZFIN:ZDB-GENO-170126-20	Zfish	PMID:27642754
Biological Process	GO:0046660	female sex differentiation	cyp19a1a	IMP	ZFIN:ZDB-GENO-170126-21	Zfish	PMID:27642754
Biological Process	GO:0030851	granulocyte differentiation	Cyp19a1	IEP		Rat	PMID:18401763\|RGD:4784626
Biological Process	GO:0007507	heart development	cyp19a1b	IMP	ZFIN:ZDB-MRPHLNO-180918-2	Zfish	PMID:31692872
Biological Process	GO:0021766	hippocampus development	Cyp19a1	IEP		Rat	PMID:21047951\|RGD:4145527
Biological Process	GO:0021854	hypothalamus development	Cyp19a1	IEP		Rat	PMID:15804399\|RGD:4891928
Biological Process	GO:0001553	luteinization	Cyp19a1	IEP		Rat	PMID:23183184\|RGD:7257725
Biological Process	GO:0019100	male germ-line sex determination	cyp19a1a	IMP	ZFIN:ZDB-GENO-180419-7	Zfish	PMID:28575219
Biological Process	GO:0008584	male gonad development	Cyp19a1	IEP		Rat	PMID:20554652\|RGD:4890355
Biological Process	GO:0030879	mammary gland development	Cyp19a1	IMP	MGI:MGI:2154536	Mouse	PMID:9618522
Biological Process	GO:0030186	melatonin metabolic process	Cyp19a1	IEP		Rat	PMID:17700567\|RGD:4890365
Biological Process	GO:0045779	negative regulation of bone resorption	Cyp19a1	IMP		Rat	PMID:8694895\|RGD:7257714
Biological Process	GO:0002677	negative regulation of chronic inflammatory response	Cyp19a1	IMP	MGI:MGI:1857043	Mouse	PMID:25447050
Biological Process	GO:0010760	negative regulation of macrophage chemotaxis	Cyp19a1	IMP	MGI:MGI:1857043	Mouse	PMID:25447050
Biological Process	GO:0001541	ovarian follicle development	cyp19a1a	IMP		Zfish	PMID:30588557
Biological Process	GO:0018963	phthalate metabolic process	Cyp19a1	IEP		Rat	PMID:20920559\|RGD:4890045
Biological Process	GO:2000866	positive regulation of estradiol secretion	CYP19A1	IDA		Human	PMID:26482249
Biological Process	GO:0060736	prostate gland growth	Cyp19a1	IMP	MGI:MGI:2154536	Mouse	PMID:16723702
Biological Process	GO:0060736	prostate gland growth	Cyp19a1	IMP	MGI:MGI:2154536	Mouse	PMID:11356695
Biological Process	GO:1904076	regulation of estrogen biosynthetic process	cyp19a1a	IMP	ZFIN:ZDB-GENO-180419-7	Zfish	PMID:28575219
Biological Process	GO:0050803	regulation of synapse structure or activity	Cyp19a1	IMP		Rat	PMID:17005180\|RGD:1600855
Biological Process	GO:0010164	response to cesium ion	Cyp19a1	IEP		Rat	PMID:20451883\|RGD:4890356
Biological Process	GO:0032355	response to estradiol	Cyp19a1	IEP		Rat	PMID:21115103\|RGD:4890040
Biological Process	GO:0032355	response to estradiol	cyp19a1b	IDA		Zfish	PMID:18041942
Biological Process	GO:0032355	response to estradiol	cyp19a1b	IDA		Zfish	PMID:19095286
Biological Process	GO:0032355	response to estradiol	cyp19a1a	IDA		Zfish	PMID:19095286
Biological Process	GO:0043627	response to estrogen	Cyp19a1	IEP		Rat	PMID:19734697\|RGD:4145613
Biological Process	GO:0043627	response to estrogen	cyp19a1b	IDA		Zfish	PMID:16458310
Biological Process	GO:0043627	response to estrogen	cyp19a1b	IDA		Zfish	ZFIN:ZDB-PUB-060309-3
Biological Process	GO:0043627	response to estrogen	cyp19a1b	IDA		Zfish	PMID:16698076
Biological Process	GO:0009635	response to herbicide	Cyp19a1	IEP		Rat	PMID:21126571\|RGD:4890039
Biological Process	GO:0010212	response to ionizing radiation	Cyp19a1	IEP		Rat	PMID:18821396\|RGD:4770368
Biological Process	GO:0010038	response to metal ion	Cyp19a1	IEP		Rat	PMID:20708649\|RGD:4890354
Biological Process	GO:0043278	response to morphine	Cyp19a1	IEP		Rat	PMID:20977699\|RGD:4890043
Biological Process	GO:0014070	response to organic cyclic compound	Cyp19a1	IEP		Rat	PMID:20821433\|RGD:4890046
Biological Process	GO:0014070	response to organic cyclic compound	Cyp19a1	IEP		Rat	PMID:28208728\|RGD:151893505
Biological Process	GO:0014070	response to organic cyclic compound	Cyp19a1	IEP		Rat	PMID:30599193\|RGD:151893501
Biological Process	GO:0048545	response to steroid hormone	cyp19a1b	IDA		Zfish	PMID:15803511
Biological Process	GO:0048545	response to steroid hormone	cyp19a1b	IDA		Zfish	PMID:18041942
Biological Process	GO:0033574	response to testosterone	Cyp19a1	IEP		Rat	PMID:16569475\|RGD:4891019
Biological Process	GO:0009410	response to xenobiotic stimulus	Cyp19a1	IEP		Rat	PMID:19497980\|RGD:2317621
Biological Process	GO:0009410	response to xenobiotic stimulus	cyp19a1b	IDA		Zfish	PMID:19095286
Biological Process	GO:0009410	response to xenobiotic stimulus	cyp19a1a	IDA		Zfish	PMID:19095286
Biological Process	GO:0061370	testosterone biosynthetic process	Cyp19a1	IMP	MGI:MGI:2154536	Mouse	PMID:9618522
Biological Process	GO:0060065	uterus development	Cyp19a1	IMP	MGI:MGI:2154536	Mouse	PMID:9618522

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.