Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP1A1
  • Mouse genes Cyp1a1
  • Rat genes Cyp1a1
  • Zfish genes cyp1a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp1a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008391	arachidonic acid monooxygenase activity	CYP1A1	IDA		Human	PMID:15041462
Molecular Function	GO:0003824	catalytic activity	Cyp1a1	IDA		Rat	PMID:10381141|RGD:2306682
Molecular Function	GO:0032451	demethylase activity	Cyp1a1	IDA		Rat	PMID:10915793|RGD:2306680
Molecular Function	GO:0032451	demethylase activity	Cyp1a1	IDA		Rat	PMID:11370669|RGD:2306679
Molecular Function	GO:0019899	enzyme binding	Cyp1a1	IDA		Rat	PMID:10891369|RGD:2306634
Molecular Function	GO:0019899	enzyme binding	Cyp1a1	IPI	RGD:2557	Rat	PMID:10891369|RGD:2306634
Molecular Function	GO:0019899	enzyme binding	Cyp1a1	IPI	RGD:68335	Rat	PMID:11350928|RGD:2306635
Molecular Function	GO:0101020	estrogen 16-alpha-hydroxylase activity	CYP1A1	IDA		Human	PMID:11555828
Molecular Function	GO:0101020	estrogen 16-alpha-hydroxylase activity	CYP1A1	IDA		Human	PMID:14559847
Molecular Function	GO:0101021	estrogen 2-hydroxylase activity	CYP1A1	IDA		Human	PMID:11555828
Molecular Function	GO:0101021	estrogen 2-hydroxylase activity	CYP1A1	IDA		Human	PMID:12865317
Molecular Function	GO:0016711	flavonoid 3'-monooxygenase activity	Cyp1a1	IDA		Rat	PMID:18057719|RGD:2301699
Molecular Function	GO:0030544	Hsp70 protein binding	Cyp1a1	IDA		Rat	PMID:19401463|RGD:13838795
Molecular Function	GO:0051879	Hsp90 protein binding	Cyp1a1	IDA		Rat	PMID:19401463|RGD:13838795
Molecular Function	GO:0120319	long-chain fatty acid omega-1 hydroxylase activity	CYP1A1	IDA		Human	PMID:18577768
Molecular Function	GO:0102033	long-chain fatty acid omega-hydroxylase activity	CYP1A1	IDA		Human	PMID:18577768
Molecular Function	GO:0004497	monooxygenase activity	Cyp1a1	IDA		Mouse	PMID:14642533
Molecular Function	GO:0004497	monooxygenase activity	Cyp1a1	IDA		Rat	PMID:12054491|RGD:2306663
Molecular Function	GO:0004497	monooxygenase activity	Cyp1a1	IDA		Rat	PMID:12464257|RGD:727674
Molecular Function	GO:0004497	monooxygenase activity	Cyp1a1	IDA		Rat	PMID:12907239|RGD:2306674
Molecular Function	GO:0004497	monooxygenase activity	Cyp1a1	IDA		Rat	PMID:8765131|RGD:2306683
Molecular Function	GO:0016491	oxidoreductase activity	CYP1A1	IDA		Human	PMID:19219744
Molecular Function	GO:0016491	oxidoreductase activity	Cyp1a1	IDA		Rat	PMID:10528997|RGD:2306681
Molecular Function	GO:0016491	oxidoreductase activity	Cyp1a1	IDA		Rat	PMID:11339718|RGD:2306677
Molecular Function	GO:0016491	oxidoreductase activity	Cyp1a1	IDA		Rat	PMID:11370669|RGD:2306679
Molecular Function	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Cyp1a1	IDA		Rat	PMID:12054491|RGD:2306663
Molecular Function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Cyp1a1	IDA		Mouse	PMID:8274012
Molecular Function	GO:0005515	protein binding	CYP1A1	IPI	UniProtKB:Q96DZ9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CYP1A1	IPI	UniProtKB:Q96DZ9-2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	Cyp1a1	IPI	UniProtKB:P61949	Rat	PMID:11350928|RGD:2306635
Molecular Function	GO:0005515	protein binding	Cyp1a1	IPI	UniProtKB:Q75Q40	Rat	PMID:19401463|RGD:13838795
Molecular Function	GO:0005515	protein binding	Cyp1a1	IPI	UniProtKB:P00257	Rat	PMID:9454608|RGD:2306636
Molecular Function	GO:0008395	steroid hydroxylase activity	Cyp1a1	IDA		Rat	PMID:11370669|RGD:2306679
Molecular Function	GO:0070576	vitamin D 24-hydroxylase activity	CYP1A1	IDA		Human	PMID:15546903
Cellular Component	GO:0005737	cytoplasm	Cyp1a1	IDA		Rat	PMID:15716480|RGD:2306666
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Cyp1a1	IDA		Rat	PMID:19219745|RGD:2306650
Cellular Component	GO:0005743	mitochondrial inner membrane	Cyp1a1	IDA		Rat	PMID:19401463|RGD:13838795
Cellular Component	GO:0005739	mitochondrion	Cyp1a1	IDA		Rat	PMID:9348277|RGD:2306653
Biological Process	GO:0042904	9-cis-retinoic acid biosynthetic process	Cyp1a1	IDA		Rat	PMID:8765131|RGD:2306683
Biological Process	GO:0007568	aging	Cyp1a1	IEP		Rat	PMID:21769602|RGD:5147748
Biological Process	GO:0009308	amine metabolic process	Cyp1a1	IMP	MGI:MGI:2182307	Mouse	PMID:17052995
Biological Process	GO:0043010	camera-type eye development	Cyp1a1	IEP		Rat	PMID:15967433|RGD:2306661
Biological Process	GO:0008283	cell population proliferation	Cyp1a1	IEP		Rat	PMID:17560764|RGD:2306656
Biological Process	GO:0006725	cellular aromatic compound metabolic process	cyp1a	IDA		Zfish	PMID:16963132
Biological Process	GO:0071280	cellular response to copper ion	Cyp1a1	IEP		Rat	PMID:24599699|RGD:11352816
Biological Process	GO:0071407	cellular response to organic cyclic compound	CYP1A1	IDA		Human	PMID:23275542
Biological Process	GO:0071407	cellular response to organic cyclic compound	cyp1a	IMP	ZFIN:ZDB-MRPHLNO-050604-1	Zfish	PMID:16330359
Biological Process	GO:0071407	cellular response to organic cyclic compound	cyp1a	IGI	ZFIN:ZDB-MRPHLNO-050604-1,ZFIN:ZDB-MRPHLNO-060104-4	Zfish	PMID:16330359
Biological Process	GO:0071407	cellular response to organic cyclic compound	cyp1a	IDA		Zfish	PMID:16330359
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	cyp1a	IMP	ZFIN:ZDB-MRPHLNO-060104-3	Zfish	PMID:16687390
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	cyp1a	IDA		Zfish	PMID:18618001
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	cyp1a	IDA		Zfish	PMID:16122694
Biological Process	GO:0009804	coumarin metabolic process	Cyp1a1	IDA		Rat	PMID:11780761|RGD:2306676
Biological Process	GO:0032502	developmental process	Cyp1a1	IEP		Rat	PMID:18926897|RGD:2306651
Biological Process	GO:0019341	dibenzo-p-dioxin catabolic process	Cyp1a1	IMP		Rat	PMID:12914780|RGD:2306673
Biological Process	GO:0019341	dibenzo-p-dioxin catabolic process	Cyp1a1	IDA		Rat	PMID:15812643|RGD:2306662
Biological Process	GO:0018894	dibenzo-p-dioxin metabolic process	Cyp1a1	IDA		Rat	PMID:12464257|RGD:727674
Biological Process	GO:0048565	digestive tract development	Cyp1a1	IEP		Rat	PMID:12162855|RGD:727721
Biological Process	GO:0006306	DNA methylation	Cyp1a1	IEP		Rat	PMID:29115507|RGD:25823175
Biological Process	GO:0008210	estrogen metabolic process	CYP1A1	IDA		Human	PMID:11555828
Biological Process	GO:0008210	estrogen metabolic process	CYP1A1	IDA		Human	PMID:12865317
Biological Process	GO:0008210	estrogen metabolic process	CYP1A1	IDA		Human	PMID:14559847
Biological Process	GO:0006631	fatty acid metabolic process	CYP1A1	IDA		Human	PMID:15041462
Biological Process	GO:0009812	flavonoid metabolic process	Cyp1a1	IDA		Rat	PMID:18057719|RGD:2301699
Biological Process	GO:0070365	hepatocyte differentiation	Cyp1a1	IEP		Rat	PMID:17574236|RGD:2306655
Biological Process	GO:0046483	heterocycle metabolic process	Cyp1a1	IMP	MGI:MGI:2182307	Mouse	PMID:17052995
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	Cyp1a1	IMP	MGI:MGI:2182307	Mouse	PMID:14980704
Biological Process	GO:0017143	insecticide metabolic process	Cyp1a1	IDA		Rat	PMID:16169030|RGD:2306660
Biological Process	GO:0002933	lipid hydroxylation	CYP1A1	IDA		Human	PMID:14559847
Biological Process	GO:0001889	liver development	Cyp1a1	IEP		Rat	PMID:12162855|RGD:727721
Biological Process	GO:0001676	long-chain fatty acid metabolic process	CYP1A1	IDA		Human	PMID:18577768
Biological Process	GO:0060137	maternal process involved in parturition	Cyp1a1	IEP		Rat	PMID:16226747|RGD:2306658
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	Cyp1a1	IDA		Rat	PMID:12907239|RGD:2306674
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	Cyp1a1	IDA		Rat	PMID:14742689|RGD:2306669
Biological Process	GO:0046677	response to antibiotic	Cyp1a1	IEP		Rat	PMID:10037757|RGD:2306685
Biological Process	GO:0046685	response to arsenic-containing substance	Cyp1a1	IEP		Rat	PMID:10329507|RGD:2306684
Biological Process	GO:0032094	response to food	Cyp1a1	IEP		Rat	PMID:15740081|RGD:2306665
Biological Process	GO:0032094	response to food	Cyp1a1	IEP		Rat	PMID:17673347|RGD:2306654
Biological Process	GO:0009635	response to herbicide	Cyp1a1	IEP		Rat	PMID:12907239|RGD:2306674
Biological Process	GO:0055093	response to hyperoxia	Cyp1a1	IEP		Rat	PMID:16497785|RGD:2306657
Biological Process	GO:0001666	response to hypoxia	Cyp1a1	IEP		Rat	PMID:11589108|RGD:2306678
Biological Process	GO:0035902	response to immobilization stress	Cyp1a1	IEP		Rat	PMID:14726153|RGD:2306670
Biological Process	GO:0010041	response to iron(III) ion	Cyp1a1	IEP		Rat	PMID:15211619|RGD:2306667
Biological Process	GO:0032496	response to lipopolysaccharide	Cyp1a1	IEP		Rat	PMID:18308837|RGD:2306652
Biological Process	GO:0009624	response to nematode	Cyp1a1	IEP		Rat	PMID:12621079|RGD:2306675
Biological Process	GO:0014070	response to organic cyclic compound	Cyp1a1	IEP		Rat	PMID:10413312|RGD:2306643
Biological Process	GO:0014070	response to organic cyclic compound	Cyp1a1	IEP		Rat	PMID:10640292|RGD:2306642
Biological Process	GO:0014070	response to organic cyclic compound	Cyp1a1	IEP		Rat	PMID:10772642|RGD:2306641
Biological Process	GO:0014070	response to organic cyclic compound	Cyp1a1	IEP		Rat	PMID:16937917|RGD:2301463
Biological Process	GO:0014070	response to organic cyclic compound	Cyp1a1	IEP		Rat	PMID:18678235|RGD:2306640
Biological Process	GO:0014070	response to organic cyclic compound	Cyp1a1	IEP		Rat	PMID:18827444|RGD:2306639
Biological Process	GO:0014070	response to organic cyclic compound	Cyp1a1	IEP		Rat	PMID:18978342|RGD:2306638
Biological Process	GO:0014070	response to organic cyclic compound	Cyp1a1	IEP		Rat	PMID:19373505|RGD:2306637
Biological Process	GO:0010033	response to organic substance	Cyp1a1	IEP		Rat	PMID:16901763|RGD:2306644
Biological Process	GO:0010033	response to organic substance	Cyp1a1	IEP		Rat	PMID:16918313|RGD:2306645
Biological Process	GO:0010033	response to organic substance	Cyp1a1	IEP		Rat	PMID:16966090|RGD:2306646
Biological Process	GO:0010033	response to organic substance	Cyp1a1	IEP		Rat	PMID:17624648|RGD:2306647
Biological Process	GO:0010033	response to organic substance	Cyp1a1	IEP		Rat	PMID:17629604|RGD:25823176
Biological Process	GO:0010033	response to organic substance	Cyp1a1	IEP		Rat	PMID:18098063|RGD:2306648
Biological Process	GO:0010033	response to organic substance	Cyp1a1	IEP		Rat	PMID:19100306|RGD:2306649
Biological Process	GO:0009636	response to toxic substance	Cyp1a1	IMP	MGI:MGI:2182307	Mouse	PMID:16377763
Biological Process	GO:0009615	response to virus	Cyp1a1	IEP		Rat	PMID:15061698|RGD:2306668
Biological Process	GO:0033189	response to vitamin A	Cyp1a1	IEP		Rat	PMID:10381141|RGD:2306682
Biological Process	GO:0009611	response to wounding	Cyp1a1	IEP		Rat	PMID:14723344|RGD:2306672
Biological Process	GO:0009410	response to xenobiotic stimulus	Cyp1a1	IEP		Rat	PMID:18774282|RGD:25823177
Biological Process	GO:0009410	response to xenobiotic stimulus	Cyp1a1	IEP		Rat	PMID:19122336|RGD:2303372
Biological Process	GO:0009410	response to xenobiotic stimulus	Cyp1a1	IEP		Rat	PMID:29115507|RGD:25823175
Biological Process	GO:0009410	response to xenobiotic stimulus	cyp1a	IDA		Zfish	PMID:17720151
Biological Process	GO:0009410	response to xenobiotic stimulus	cyp1a	IDA		Zfish	PMID:17433458
Biological Process	GO:0009410	response to xenobiotic stimulus	cyp1a	IDA		Zfish	PMID:18973944
Biological Process	GO:0042572	retinol metabolic process	CYP1A1	IDA		Human	PMID:10681376
Biological Process	GO:0008202	steroid metabolic process	CYP1A1	IDA		Human	PMID:14559847
Biological Process	GO:0009404	toxin metabolic process	Cyp1a1	IMP	MGI:MGI:2182307	Mouse	PMID:17166882
Biological Process	GO:0006805	xenobiotic metabolic process	CYP1A1	IDA		Human	PMID:19219744

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern