Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP1A2
  • Mouse genes Cyp1a2
  • Rat genes Cyp1a2
  • Zfish genes cyp1a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp1a2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034875	caffeine oxidase activity	CYP1A2	IDA		Human	PMID:18619574
Molecular Function	GO:0032451	demethylase activity	CYP1A2	IDA		Human	PMID:2813353
Molecular Function	GO:0019899	enzyme binding	CYP1A2	IPI	UniProtKB:P00167	Human	PMID:15680923
Molecular Function	GO:0019899	enzyme binding	CYP1A2	IPI	UniProtKB:P00388	Human	PMID:15680923
Molecular Function	GO:0101020	estrogen 16-alpha-hydroxylase activity	CYP1A2	IDA		Human	PMID:11555828
Molecular Function	GO:0101021	estrogen 2-hydroxylase activity	CYP1A2	IDA		Human	PMID:11555828
Molecular Function	GO:0101021	estrogen 2-hydroxylase activity	CYP1A2	IDA		Human	PMID:12865317
Molecular Function	GO:0020037	heme binding	CYP1A2	IDA		Human	PMID:17311915
Molecular Function	GO:0004497	monooxygenase activity	CYP1A2	IDA		Human	PMID:15327587
Molecular Function	GO:0004497	monooxygenase activity	CYP1A2	IDA		Human	PMID:19651758
Molecular Function	GO:0004497	monooxygenase activity	Cyp1a2	IDA		Rat	PMID:12162855|RGD:727721
Molecular Function	GO:0016491	oxidoreductase activity	CYP1A2	IDA		Human	PMID:16401082
Molecular Function	GO:0016491	oxidoreductase activity	CYP1A2	IDA		Human	PMID:19219744
Molecular Function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP1A2	IMP		Human	PMID:2813353
Molecular Function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Cyp1a2	IDA		Mouse	PMID:8274012
Molecular Function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Cyp1a2	IDA		Rat	PMID:1441600|RGD:2303379
Molecular Function	GO:0005515	protein binding	CYP1A2	IPI	UniProtKB:O00264	Human	PMID:26988023
Molecular Function	GO:0005515	protein binding	CYP1A2	IPI	UniProtKB:O95870	Human	PMID:32296183
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CYP1A2	IDA		Human	PMID:2813353
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Cyp1a2	IDA		Rat	PMID:12162855|RGD:727721
Biological Process	GO:0009820	alkaloid metabolic process	CYP1A2	IDA		Human	PMID:11511187
Biological Process	GO:0006725	cellular aromatic compound metabolic process	Cyp1a2	IMP	MGI:MGI:1861917	Mouse	PMID:9240455
Biological Process	GO:0006725	cellular aromatic compound metabolic process	cyp1a	IDA		Zfish	PMID:16963132
Biological Process	GO:0045333	cellular respiration	Cyp1a2	IMP	MGI:MGI:1861917	Mouse	PMID:7761462
Biological Process	GO:0071276	cellular response to cadmium ion	Cyp1a2	IDA		Mouse	PMID:16183037
Biological Process	GO:0071280	cellular response to copper ion	Cyp1a2	IEP		Rat	PMID:24599699|RGD:11352816
Biological Process	GO:0071407	cellular response to organic cyclic compound	cyp1a	IMP	ZFIN:ZDB-MRPHLNO-050604-1	Zfish	PMID:16330359
Biological Process	GO:0071407	cellular response to organic cyclic compound	cyp1a	IGI	ZFIN:ZDB-MRPHLNO-050604-1,ZFIN:ZDB-MRPHLNO-060104-4	Zfish	PMID:16330359
Biological Process	GO:0071407	cellular response to organic cyclic compound	cyp1a	IDA		Zfish	PMID:16330359
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	cyp1a	IMP	ZFIN:ZDB-MRPHLNO-060104-3	Zfish	PMID:16687390
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	cyp1a	IDA		Zfish	PMID:18618001
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	cyp1a	IDA		Zfish	PMID:16122694
Biological Process	GO:0018894	dibenzo-p-dioxin metabolic process	Cyp1a2	IMP	MGI:MGI:1861917	Mouse	PMID:9240455
Biological Process	GO:0018894	dibenzo-p-dioxin metabolic process	Cyp1a2	IMP	MGI:MGI:2182351	Mouse	PMID:16636061
Biological Process	GO:0008210	estrogen metabolic process	CYP1A2	IDA		Human	PMID:11555828
Biological Process	GO:0008210	estrogen metabolic process	CYP1A2	IDA		Human	PMID:12865317
Biological Process	GO:0046483	heterocycle metabolic process	CYP1A2	IDA		Human	PMID:15327587
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	Cyp1a2	IMP	MGI:MGI:2182351	Mouse	PMID:14980704
Biological Process	GO:0030324	lung development	Cyp1a2	IMP	MGI:MGI:1861917	Mouse	PMID:7761462
Biological Process	GO:0032787	monocarboxylic acid metabolic process	CYP1A2	IDA		Human	PMID:19651758
Biological Process	GO:0016098	monoterpenoid metabolic process	CYP1A2	IDA		Human	PMID:16401082
Biological Process	GO:0070989	oxidative demethylation	CYP1A2	IDA		Human	PMID:18619574
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	Cyp1a2	IMP	MGI:MGI:2182351	Mouse	PMID:9461503
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	Cyp1a2	IMP	MGI:MGI:2182351	Mouse	PMID:11274970
Biological Process	GO:0009791	post-embryonic development	Cyp1a2	IMP	MGI:MGI:1861917	Mouse	PMID:7761462
Biological Process	GO:0010468	regulation of gene expression	Cyp1a2	IMP	MGI:MGI:1861917	Mouse	PMID:12438513
Biological Process	GO:0032355	response to estradiol	Cyp1a2	IEP		Rat	PMID:18992763|RGD:2303373
Biological Process	GO:0035902	response to immobilization stress	Cyp1a2	IEP		Rat	PMID:17973897|RGD:2303378
Biological Process	GO:0032496	response to lipopolysaccharide	Cyp1a2	IEP		Rat	PMID:18314883|RGD:2303377
Biological Process	GO:0014070	response to organic cyclic compound	Cyp1a2	IEP		Rat	PMID:18754104|RGD:2303374
Biological Process	GO:0010033	response to organic substance	Cyp1a2	IEP		Rat	PMID:19177741|RGD:2303371
Biological Process	GO:0009410	response to xenobiotic stimulus	Cyp1a2	IEP		Rat	PMID:19122336|RGD:2303372
Biological Process	GO:0009410	response to xenobiotic stimulus	cyp1a	IDA		Zfish	PMID:17720151
Biological Process	GO:0009410	response to xenobiotic stimulus	cyp1a	IDA		Zfish	PMID:17433458
Biological Process	GO:0009410	response to xenobiotic stimulus	cyp1a	IDA		Zfish	PMID:18973944
Biological Process	GO:0042572	retinol metabolic process	CYP1A2	IDA		Human	PMID:10681376
Biological Process	GO:0006706	steroid catabolic process	CYP1A2	IMP		Human	PMID:18356043
Biological Process	GO:0009403	toxin biosynthetic process	CYP1A2	IDA		Human	PMID:11511187
Biological Process	GO:0009404	toxin metabolic process	Cyp1a2	IMP	MGI:MGI:2182351	Mouse	PMID:17166882
Biological Process	GO:0042178	xenobiotic catabolic process	CYP1A2	IMP		Human	PMID:18356043
Biological Process	GO:0042178	xenobiotic catabolic process	CYP1A2	IDA		Human	PMID:18619574
Biological Process	GO:0006805	xenobiotic metabolic process	CYP1A2	IDA		Human	PMID:15327587
Biological Process	GO:0006805	xenobiotic metabolic process	CYP1A2	IDA		Human	PMID:19219744
Biological Process	GO:0006805	xenobiotic metabolic process	Cyp1a2	IMP	MGI:MGI:2182351	Mouse	PMID:8643688
Biological Process	GO:0006805	xenobiotic metabolic process	Cyp1a2	IDA		Rat	PMID:6772643|RGD:151347456

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern