Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP1B1
  • Mouse genes Cyp1b1
  • Rat genes Cyp1b1
  • Zfish genes cyp1b1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp1b1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0101020	estrogen 16-alpha-hydroxylase activity	CYP1B1	IDA		Human	PMID:11555828
Molecular Function	GO:0020037	heme binding	CYP1B1	IDA		Human	PMID:21147782
Molecular Function	GO:0004497	monooxygenase activity	CYP1B1	IDA		Human	PMID:15258110
Molecular Function	GO:0004497	monooxygenase activity	CYP1B1	IDA		Human	PMID:23821647
Molecular Function	GO:0004497	monooxygenase activity	Cyp1b1	IDA		Mouse	MGI:MGI:5572883|PMID:15258110
Molecular Function	GO:0004497	monooxygenase activity	Cyp1b1	IDA		Mouse	MGI:MGI:5574571|PMID:23821647
Molecular Function	GO:0004497	monooxygenase activity	Cyp1b1	IDA		Rat	PMID:15258110|RGD:8661626
Molecular Function	GO:0004497	monooxygenase activity	Cyp1b1	IDA		Rat	PMID:23821647|RGD:7829732
Molecular Function	GO:0016491	oxidoreductase activity	Cyp1b1	IDA		Rat	PMID:16893557|RGD:1599718
Molecular Function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP1B1	IDA		Human	PMID:10871058
Molecular Function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Cyp1b1	IDA		Mouse	PMID:9367523
Molecular Function	GO:0005515	protein binding	CYP1B1	IPI	UniProtKB:Q02763	Human	PMID:28620713
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Cyp1b1	IDA		Rat	PMID:7744798|RGD:728267
Cellular Component	GO:0005739	mitochondrion	Cyp1b1	IMP		Mouse	MGI:MGI:5525209|PMID:23692925
Cellular Component	GO:0005634	nucleus	Cyp1b1	IDA		Rat	PMID:12051558|RGD:7829757
Biological Process	GO:0030325	adrenal gland development	Cyp1b1	IEP		Rat	PMID:10098502|RGD:7829725
Biological Process	GO:0001525	angiogenesis	Cyp1b1	IMP	MGI:MGI:2154690	Mouse	PMID:19005183
Biological Process	GO:0019369	arachidonic acid metabolic process	CYP1B1	IDA		Human	PMID:15258110
Biological Process	GO:0019369	arachidonic acid metabolic process	Cyp1b1	IDA		Mouse	MGI:MGI:5572883|PMID:15258110
Biological Process	GO:0042537	benzene-containing compound metabolic process	Cyp1b1	IMP		Rat	PMID:24025706|RGD:7829724
Biological Process	GO:0042537	benzene-containing compound metabolic process	Cyp1b1	IDA		Rat	PMID:9806168|RGD:7800739
Biological Process	GO:0043534	blood vessel endothelial cell migration	Cyp1b1	IMP	MGI:MGI:2154690	Mouse	PMID:19005183
Biological Process	GO:0048514	blood vessel morphogenesis	Cyp1b1	IMP		Mouse	MGI:MGI:5492227|PMID:23568032
Biological Process	GO:0007155	cell adhesion	Cyp1b1	IMP		Mouse	MGI:MGI:5544856|PMID:23979599
Biological Process	GO:0006725	cellular aromatic compound metabolic process	Cyp1b1	IDA		Mouse	PMID:1910294
Biological Process	GO:0006725	cellular aromatic compound metabolic process	Cyp1b1	IMP		Mouse	PMID:9367523
Biological Process	GO:0006725	cellular aromatic compound metabolic process	Cyp1b1	IMP		Mouse	PMID:9377560
Biological Process	GO:0006725	cellular aromatic compound metabolic process	Cyp1b1	IMP	MGI:MGI:2154690	Mouse	PMID:10051580
Biological Process	GO:0006725	cellular aromatic compound metabolic process	Cyp1b1	IDA		Rat	PMID:7744798|RGD:728267
Biological Process	GO:0071320	cellular response to cAMP	Cyp1b1	IEP		Rat	PMID:21389345|RGD:7800737
Biological Process	GO:0071387	cellular response to cortisol stimulus	Cyp1b1	IEP		Rat	PMID:8674863|RGD:7829730
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Cyp1b1	IMP		Mouse	MGI:MGI:5544856|PMID:23979599
Biological Process	GO:0071373	cellular response to luteinizing hormone stimulus	Cyp1b1	IEP		Rat	PMID:21389345|RGD:7800737
Biological Process	GO:0071407	cellular response to organic cyclic compound	CYP1B1	IDA		Human	PMID:23275542
Biological Process	GO:0071393	cellular response to progesterone stimulus	Cyp1b1	IEP		Rat	PMID:8674863|RGD:7829730
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Cyp1b1	IEP		Rat	PMID:10403529|RGD:7815048
Biological Process	GO:0030199	collagen fibril organization	Cyp1b1	IMP		Mouse	MGI:MGI:5544856|PMID:23979599
Biological Process	GO:0006304	DNA modification	Cyp1b1	IMP		Rat	PMID:24025706|RGD:7829724
Biological Process	GO:0043542	endothelial cell migration	Cyp1b1	IMP		Mouse	MGI:MGI:4431324|PMID:20032512
Biological Process	GO:0071603	endothelial cell-cell adhesion	Cyp1b1	IMP	MGI:MGI:2154690	Mouse	PMID:19005183
Biological Process	GO:0008210	estrogen metabolic process	CYP1B1	IDA		Human	PMID:11555828
Biological Process	GO:0008210	estrogen metabolic process	CYP1B1	IDA		Human	PMID:12865317
Biological Process	GO:0008210	estrogen metabolic process	CYP1B1	IDA		Human	PMID:23821647
Biological Process	GO:0008210	estrogen metabolic process	Cyp1b1	IDA		Mouse	MGI:MGI:5574571|PMID:23821647
Biological Process	GO:0008210	estrogen metabolic process	Cyp1b1	IMP		Rat	PMID:16893557|RGD:1599718
Biological Process	GO:0008210	estrogen metabolic process	Cyp1b1	IDA		Rat	PMID:23821647|RGD:7829732
Biological Process	GO:0044849	estrous cycle	Cyp1b1	IEP		Rat	PMID:12223220|RGD:7829740
Biological Process	GO:0001654	eye development	cyp1b1	IMP	ZFIN:ZDB-MRPHLNO-081219-1	Zfish	PMID:28192799
Biological Process	GO:0001654	eye development	cyp1b1	IMP	ZFIN:ZDB-MRPHLNO-170329-3	Zfish	PMID:28192799
Biological Process	GO:0061548	ganglion development	Cyp1b1	IEP		Rat	PMID:17687037|RGD:7800681
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	Cyp1b1	IMP		Mouse	MGI:MGI:5492227|PMID:23568032
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	Cyp1b1	IMP		Mouse	MGI:MGI:5544856|PMID:23979599
Biological Process	GO:0008584	male gonad development	Cyp1b1	IEP		Rat	PMID:19074971|RGD:7815049
Biological Process	GO:0046466	membrane lipid catabolic process	Cyp1b1	IMP		Mouse	MGI:MGI:3829820|PMID:19005183
Biological Process	GO:0046466	membrane lipid catabolic process	Cyp1b1	IMP		Mouse	MGI:MGI:5544856|PMID:23979599
Biological Process	GO:0033629	negative regulation of cell adhesion mediated by integrin	Cyp1b1	IMP		Mouse	MGI:MGI:5492227|PMID:23568032
Biological Process	GO:0030336	negative regulation of cell migration	Cyp1b1	IMP		Mouse	MGI:MGI:5492227|PMID:23568032
Biological Process	GO:0008285	negative regulation of cell population proliferation	Cyp1b1	IMP		Mouse	MGI:MGI:5492227|PMID:23568032
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	Cyp1b1	IMP		Mouse	MGI:MGI:5492227|PMID:23568032
Biological Process	GO:0006809	nitric oxide biosynthetic process	Cyp1b1	IMP		Mouse	MGI:MGI:4431324|PMID:20032512
Biological Process	GO:0045766	positive regulation of angiogenesis	Cyp1b1	IMP		Mouse	MGI:MGI:4431324|PMID:20032512
Biological Process	GO:0043065	positive regulation of apoptotic process	Cyp1b1	IMP		Mouse	MGI:MGI:5492227|PMID:23568032
Biological Process	GO:0043065	positive regulation of apoptotic process	Cyp1b1	IEP		Rat	PMID:18336843|RGD:7829717
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	Cyp1b1	IMP		Rat	PMID:20439821|RGD:7829726
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	Cyp1b1	IMP		Rat	PMID:20439821|RGD:7829726
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	Cyp1b1	IMP		Mouse	MGI:MGI:5492227|PMID:23568032
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Cyp1b1	IMP		Rat	PMID:20439821|RGD:7829726
Biological Process	GO:0045727	positive regulation of translation	Cyp1b1	IMP		Rat	PMID:20439821|RGD:7829726
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	Cyp1b1	IMP		Mouse	MGI:MGI:5492227|PMID:23568032
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	Cyp1b1	IMP		Mouse	MGI:MGI:3829820|PMID:19005183
Biological Process	GO:0046685	response to arsenic-containing substance	Cyp1b1	IEP		Rat	PMID:23999541|RGD:7829758
Biological Process	GO:0071548	response to dexamethasone	Cyp1b1	IEP		Rat	PMID:9804617|RGD:7815047
Biological Process	GO:0032355	response to estradiol	Cyp1b1	IEP		Rat	PMID:19074971|RGD:7815049
Biological Process	GO:0032354	response to follicle-stimulating hormone	Cyp1b1	IEP		Rat	PMID:19074971|RGD:7815049
Biological Process	GO:0071680	response to indole-3-methanol	Cyp1b1	IEP		Rat	PMID:11719698|RGD:7829743
Biological Process	GO:0007584	response to nutrient	Cyp1b1	IEP		Rat	PMID:11739881|RGD:7829754
Biological Process	GO:0014070	response to organic cyclic compound	Cyp1b1	IEP		Rat	PMID:7744798|RGD:728267
Biological Process	GO:0010033	response to organic substance	Cyp1b1	IEP		Rat	PMID:16901605|RGD:1599717
Biological Process	GO:0048545	response to steroid hormone	Cyp1b1	IEP		Rat	PMID:12704664|RGD:7829755
Biological Process	GO:0009636	response to toxic substance	Cyp1b1	IMP	MGI:MGI:2154690	Mouse	PMID:16377763
Biological Process	GO:0009636	response to toxic substance	Cyp1b1	IEP		Rat	PMID:7788849|RGD:727688
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Cyp1b1	IMP	MGI:MGI:2154690	Mouse	PMID:19005183
Biological Process	GO:0061304	retinal blood vessel morphogenesis	Cyp1b1	IMP		Mouse	MGI:MGI:4431324|PMID:20032512
Biological Process	GO:0042574	retinal metabolic process	CYP1B1	IDA		Human	PMID:15258110
Biological Process	GO:0042574	retinal metabolic process	Cyp1b1	IDA		Mouse	MGI:MGI:5572883|PMID:15258110
Biological Process	GO:0042572	retinol metabolic process	CYP1B1	IDA		Human	PMID:10681376
Biological Process	GO:0042572	retinol metabolic process	CYP1B1	IDA		Human	PMID:15258110
Biological Process	GO:0042572	retinol metabolic process	Cyp1b1	IDA		Mouse	MGI:MGI:5572883|PMID:15258110
Biological Process	GO:0008202	steroid metabolic process	CYP1B1	IDA		Human	PMID:22888116
Biological Process	GO:0009404	toxin metabolic process	Cyp1b1	IMP	MGI:MGI:2154690	Mouse	PMID:17166882
Biological Process	GO:0009404	toxin metabolic process	Cyp1b1	IMP	MGI:MGI:2154690	Mouse	PMID:10051580
Biological Process	GO:0002930	trabecular meshwork development	Cyp1b1	IMP		Mouse	MGI:MGI:5544856|PMID:23979599
Biological Process	GO:0006805	xenobiotic metabolic process	CYP1B1	IDA		Human	PMID:22888116

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern