Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP26A1
  • Mouse genes Cyp26a1
  • Rat genes Cyp26a1
  • Zfish genes cyp26a1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp26a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0062183	all-trans retinoic acid 18-hydroxylase activity	CYP26A1	IDA		Human	PMID:22020119
Molecular Function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	CYP26A1	IDA		Human	PMID:26937021
Molecular Function	GO:0008401	retinoic acid 4-hydroxylase activity	CYP26A1	IDA		Human	PMID:10823918
Molecular Function	GO:0008401	retinoic acid 4-hydroxylase activity	CYP26A1	IDA		Human	PMID:9228017
Molecular Function	GO:0008401	retinoic acid 4-hydroxylase activity	CYP26A1	IDA		Human	PMID:9716180
Molecular Function	GO:0008401	retinoic acid 4-hydroxylase activity	Cyp26a1	IDA		Mouse	MGI:MGI:1195386|PMID:9442090
Molecular Function	GO:0008401	retinoic acid 4-hydroxylase activity	Cyp26a1	IDA		Mouse	PMID:9250660
Molecular Function	GO:0008401	retinoic acid 4-hydroxylase activity	cyp26a1	IDA		Zfish	PMID:8939936
Molecular Function	GO:0001972	retinoic acid binding	CYP26A1	IDA		Human	PMID:10823918
Biological Process	GO:0009952	anterior/posterior pattern specification	Cyp26a1	IGI	MGI:MGI:2679699	Mouse	PMID:17067568
Biological Process	GO:0009952	anterior/posterior pattern specification	Cyp26a1	IMP	MGI:MGI:2183292	Mouse	PMID:17067568
Biological Process	GO:0034672	anterior/posterior pattern specification involved in pronephros development	cyp26a1	IMP	ZFIN:ZDB-MRPHLNO-050316-1	Zfish	PMID:27406002
Biological Process	GO:0055014	atrial cardiac muscle cell development	cyp26a1	IGI	ZFIN:ZDB-MRPHLNO-070410-6,ZFIN:ZDB-MRPHLNO-131002-1,ZFIN:ZDB-MRPHLNO-131002-2	Zfish	PMID:24667328
Biological Process	GO:0055014	atrial cardiac muscle cell development	cyp26a1	IGI	ZFIN:ZDB-GENO-070411-2,ZFIN:ZDB-MRPHLNO-070410-6	Zfish	PMID:24667328
Biological Process	GO:0001568	blood vessel development	cyp26a1	IMP	ZFIN:ZDB-GENO-050324-1	Zfish	PMID:15680360
Biological Process	GO:0001568	blood vessel development	cyp26a1	IMP	ZFIN:ZDB-MRPHLNO-050316-1	Zfish	PMID:15680360
Biological Process	GO:0048854	brain morphogenesis	cyp26a1	IMP	ZFIN:ZDB-GENO-070411-2	Zfish	PMID:17998248
Biological Process	GO:0071300	cellular response to retinoic acid	Cyp26a1	IEP		Mouse	MGI:MGI:3809313|PMID:18816858
Biological Process	GO:0071299	cellular response to vitamin A	cyp26a1	IDA		Zfish	PMID:17253779
Biological Process	GO:0007417	central nervous system development	Cyp26a1	IMP	MGI:MGI:2183292	Mouse	PMID:17067568
Biological Process	GO:0007417	central nervous system development	Cyp26a1	IGI	MGI:MGI:2679699	Mouse	PMID:17067568
Biological Process	GO:0021797	forebrain anterior/posterior pattern specification	cyp26a1	IGI	ZFIN:ZDB-GENE-990415-44,ZFIN:ZDB-MRPHLNO-080501-1	Zfish	PMID:17998248
Biological Process	GO:0007507	heart development	cyp26a1	IMP	ZFIN:ZDB-MRPHLNO-131002-1,ZFIN:ZDB-MRPHLNO-131002-2	Zfish	PMID:23990796
Biological Process	GO:0007507	heart development	cyp26a1	IGI	ZFIN:ZDB-MRPHLNO-131002-1,ZFIN:ZDB-MRPHLNO-131002-2,ZFIN:ZDB-MRPHLNO-131018-1	Zfish	PMID:23990796
Biological Process	GO:0030902	hindbrain development	cyp26a1	IMP	ZFIN:ZDB-GENO-050324-1	Zfish	PMID:15680360
Biological Process	GO:0030902	hindbrain development	cyp26a1	IGI	ZFIN:ZDB-GENO-070411-2,ZFIN:ZDB-MRPHLNO-070410-1,ZFIN:ZDB-MRPHLNO-070410-6	Zfish	PMID:17164423
Biological Process	GO:0001822	kidney development	Cyp26a1	IEP		Rat	PMID:15567713|RGD:2306322
Biological Process	GO:0003131	mesodermal-endodermal cell signaling	cyp26a1	IMP	ZFIN:ZDB-GENO-070411-2	Zfish	PMID:19416885
Biological Process	GO:0030917	midbrain-hindbrain boundary development	cyp26a1	IGI	ZFIN:ZDB-MRPHLNO-131002-1,ZFIN:ZDB-MRPHLNO-131002-2,ZFIN:ZDB-MRPHLNO-131018-1	Zfish	PMID:23990796
Biological Process	GO:0014032	neural crest cell development	Cyp26a1	IGI	MGI:MGI:2679699	Mouse	PMID:17067568
Biological Process	GO:0003151	outflow tract morphogenesis	cyp26a1	IGI	ZFIN:ZDB-MRPHLNO-070410-6,ZFIN:ZDB-MRPHLNO-131002-1	Zfish	PMID:27893754
Biological Process	GO:0031016	pancreas development	cyp26a1	IGI	ZFIN:ZDB-GENO-070411-2,ZFIN:ZDB-MRPHLNO-070410-1,ZFIN:ZDB-MRPHLNO-070410-6	Zfish	PMID:19416885
Biological Process	GO:0031016	pancreas development	cyp26a1	IMP	ZFIN:ZDB-GENO-070411-2	Zfish	PMID:19416885
Biological Process	GO:0032526	response to retinoic acid	Cyp26a1	IEP		Rat	PMID:19700416|RGD:6484694
Biological Process	GO:0033189	response to vitamin A	Cyp26a1	IEP		Rat	PMID:19700416|RGD:6484694
Biological Process	GO:0042574	retinal metabolic process	cyp26a1	IMP	ZFIN:ZDB-GENO-070411-2	Zfish	PMID:17164423
Biological Process	GO:0034653	retinoic acid catabolic process	CYP26A1	IDA		Human	PMID:10823918
Biological Process	GO:0034653	retinoic acid catabolic process	Cyp26a1	IDA		Mouse	PMID:9250660
Biological Process	GO:0034653	retinoic acid catabolic process	cyp26a1	IMP		Zfish	PMID:19416885
Biological Process	GO:0042573	retinoic acid metabolic process	CYP26A1	IDA		Human	PMID:22020119
Biological Process	GO:0042573	retinoic acid metabolic process	CYP26A1	IDA		Human	PMID:9716180
Biological Process	GO:0042573	retinoic acid metabolic process	Cyp26a1	IDA		Mouse	MGI:MGI:1195386|PMID:9442090
Biological Process	GO:0042573	retinoic acid metabolic process	Cyp26a1	IDA		Mouse	MGI:MGI:894533|PMID:9250660
Biological Process	GO:0042573	retinoic acid metabolic process	Cyp26a1	IMP	MGI:MGI:2183292	Mouse	PMID:15531370
Biological Process	GO:0042573	retinoic acid metabolic process	cyp26a1	IDA		Zfish	PMID:8939936
Biological Process	GO:0042573	retinoic acid metabolic process	cyp26a1	IDA		Zfish	PMID:16455818
Biological Process	GO:0042573	retinoic acid metabolic process	cyp26a1	IMP	ZFIN:ZDB-GENO-070411-2	Zfish	PMID:17164423
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	Cyp26a1	IDA		Mouse	PMID:9250660
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	Cyp26a1	IGI	MGI:MGI:2679699	Mouse	PMID:17067568
Biological Process	GO:0090242	retinoic acid receptor signaling pathway involved in somitogenesis	cyp26a1	IMP	ZFIN:ZDB-MRPHLNO-140205-4	Zfish	PMID:23975936
Biological Process	GO:0021661	rhombomere 4 morphogenesis	cyp26a1	IGI	ZFIN:ZDB-GENO-070411-2,ZFIN:ZDB-MRPHLNO-070410-1	Zfish	PMID:17164423
Biological Process	GO:0021661	rhombomere 4 morphogenesis	cyp26a1	IGI	ZFIN:ZDB-GENO-070411-2,ZFIN:ZDB-MRPHLNO-070410-6	Zfish	PMID:17164423
Biological Process	GO:0021661	rhombomere 4 morphogenesis	cyp26a1	IGI	ZFIN:ZDB-GENO-070411-2,ZFIN:ZDB-MRPHLNO-070410-1,ZFIN:ZDB-MRPHLNO-070410-6	Zfish	PMID:17164423
Biological Process	GO:0021661	rhombomere 4 morphogenesis	cyp26a1	IMP	ZFIN:ZDB-GENO-070411-2	Zfish	PMID:17164423
Biological Process	GO:0001756	somitogenesis	cyp26a1	IMP	ZFIN:ZDB-MRPHLNO-050316-1	Zfish	PMID:17098223
Biological Process	GO:0001944	vasculature development	cyp26a1	IGI	ZFIN:ZDB-MRPHLNO-070410-6,ZFIN:ZDB-MRPHLNO-131002-1,ZFIN:ZDB-MRPHLNO-131002-2	Zfish	PMID:24667328
Biological Process	GO:0001944	vasculature development	cyp26a1	IGI	ZFIN:ZDB-GENO-070411-2,ZFIN:ZDB-MRPHLNO-070410-6	Zfish	PMID:24667328
Biological Process	GO:0006805	xenobiotic metabolic process	CYP26A1	IDA		Human	PMID:26937021

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern