Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP27A1
  • Mouse genes Cyp27a1
  • Rat genes Cyp27a1
  • Zfish genes cyp27a1.2,cyp27a1.4,cyp27a7,si:dkey-91i10.3,zgc:136333
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp27a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047749	cholestanetriol 26-monooxygenase activity	CYP27A1	IDA		Human	PMID:11412116
Molecular Function	GO:0031073	cholesterol 26-hydroxylase activity	CYP27A1	IDA		Human	PMID:12077124
Molecular Function	GO:0031073	cholesterol 26-hydroxylase activity	CYP27A1	IDA		Human	PMID:9660774
Molecular Function	GO:0031073	cholesterol 26-hydroxylase activity	Cyp27a1	IDA		Rat	PMID:2175615|RGD:1299597
Molecular Function	GO:0020037	heme binding	CYP27A1	IDA		Human	PMID:9660774
Molecular Function	GO:0030544	Hsp70 protein binding	Cyp27a1	IDA		Rat	PMID:19401463|RGD:13838795
Molecular Function	GO:0030343	vitamin D3 25-hydroxylase activity	CYP27A1	IDA		Human	PMID:15465040
Molecular Function	GO:0030343	vitamin D3 25-hydroxylase activity	Cyp27a1	IDA		Rat	PMID:2175615|RGD:1299597
Cellular Component	GO:0005740	mitochondrial envelope	Cyp27a1	IDA		Rat	PMID:2175615|RGD:1299597
Cellular Component	GO:0005743	mitochondrial inner membrane	Cyp27a1	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005743	mitochondrial inner membrane	Cyp27a1	IDA		Rat	PMID:19401463|RGD:13838795
Cellular Component	GO:0005739	mitochondrion	Cyp27a1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Cyp27a1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Cyp27a1	IDA		Rat	PMID:12909643|RGD:1600873
Biological Process	GO:0006699	bile acid biosynthetic process	CYP27A1	IDA		Human	PMID:11412116
Biological Process	GO:0006699	bile acid biosynthetic process	CYP27A1	IDA		Human	PMID:9660774
Biological Process	GO:0036378	calcitriol biosynthetic process from calciol	CYP27A1	IDA		Human	PMID:15465040
Biological Process	GO:0006707	cholesterol catabolic process	CYP27A1	IDA		Human	PMID:9660774
Biological Process	GO:0008203	cholesterol metabolic process	Cyp27a1	IDA		Rat	PMID:2175615|RGD:1299597

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern