Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP27B1
  • Mouse genes Cyp27b1
  • Rat genes Cyp27b1
  • Zfish genes cyp27b1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp27b1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004498	calcidiol 1-monooxygenase activity	CYP27B1	IDA		Human	PMID:15795327
Molecular Function	GO:0004498	calcidiol 1-monooxygenase activity	CYP27B1	IDA		Human	PMID:16549446
Molecular Function	GO:0004498	calcidiol 1-monooxygenase activity	CYP27B1	IDA		Human	PMID:17023519
Molecular Function	GO:0004498	calcidiol 1-monooxygenase activity	CYP27B1	IDA		Human	PMID:22862690
Molecular Function	GO:0004498	calcidiol 1-monooxygenase activity	CYP27B1	IDA		Human	PMID:9415400
Molecular Function	GO:0004498	calcidiol 1-monooxygenase activity	Cyp27b1	IDA		Mouse	MGI:MGI:3590419|PMID:15972816
Molecular Function	GO:0004498	calcidiol 1-monooxygenase activity	Cyp27b1	IDA		Mouse	MGI:MGI:1097206|PMID:9295274
Molecular Function	GO:0004498	calcidiol 1-monooxygenase activity	Cyp27b1	IDA		Rat	PMID:9333115|RGD:69373
Molecular Function	GO:0004498	calcidiol 1-monooxygenase activity	Cyp27b1	IDA		Rat	PMID:9371776|RGD:69372
Molecular Function	GO:0004498	calcidiol 1-monooxygenase activity	cyp27b1	IDA		Zfish	PMID:25290078
Molecular Function	GO:0062185	secalciferol 1-monooxygenase activity	CYP27B1	IDA		Human	PMID:10518789
Cellular Component	GO:0005737	cytoplasm	CYP27B1	IDA		Human	PMID:15589699
Cellular Component	GO:0005737	cytoplasm	CYP27B1	IDA		Human	PMID:16720713
Cellular Component	GO:0005739	mitochondrion	Cyp27b1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Cyp27b1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Cyp27b1	IDA		Rat	PMID:9426217|RGD:2307316
Biological Process	GO:0007568	aging	Cyp27b1	IDA		Rat	PMID:3496213|RGD:2307323
Biological Process	GO:0030282	bone mineralization	CYP27B1	IEP		Human	PMID:17023519
Biological Process	GO:0036378	calcitriol biosynthetic process from calciol	CYP27B1	IDA		Human	PMID:15795327
Biological Process	GO:0036378	calcitriol biosynthetic process from calciol	CYP27B1	IDA		Human	PMID:16549446
Biological Process	GO:0036378	calcitriol biosynthetic process from calciol	CYP27B1	IDA		Human	PMID:17023519
Biological Process	GO:0036378	calcitriol biosynthetic process from calciol	CYP27B1	IDA		Human	PMID:22862690
Biological Process	GO:0036378	calcitriol biosynthetic process from calciol	CYP27B1	IDA		Human	PMID:9415400
Biological Process	GO:0036378	calcitriol biosynthetic process from calciol	Cyp27b1	IDA		Mouse	MGI:MGI:3590419|PMID:15972816
Biological Process	GO:0036378	calcitriol biosynthetic process from calciol	cyp27b1	IDA		Zfish	PMID:25290078|ZFIN:ZDB-PUB-141008-3
Biological Process	GO:0055074	calcium ion homeostasis	CYP27B1	IMP		Human	PMID:9415400
Biological Process	GO:0006816	calcium ion transport	Cyp27b1	IMP	MGI:MGI:2182334	Mouse	PMID:12205031
Biological Process	GO:0046697	decidualization	CYP27B1	IEP		Human	PMID:16720713
Biological Process	GO:0070314	G1 to G0 transition	CYP27B1	IMP		Human	PMID:12496369
Biological Process	GO:0071425	hematopoietic stem cell proliferation	cyp27b1	IMP	ZFIN:ZDB-MRPHLNO-161129-7	Zfish	PMID:27705794
Biological Process	GO:0007595	lactation	Cyp27b1	IEP		Rat	PMID:8333523|RGD:2307320
Biological Process	GO:1900155	negative regulation of bone trabecula formation	Cyp27b1	IMP		Rat	PMID:32231239|RGD:32716373
Biological Process	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity	CYP27B1	IDA		Human	PMID:16549446
Biological Process	GO:0030308	negative regulation of cell growth	CYP27B1	IMP		Human	PMID:12496369
Biological Process	GO:0008285	negative regulation of cell population proliferation	CYP27B1	IDA		Human	PMID:16549446
Biological Process	GO:0030279	negative regulation of ossification	Cyp27b1	IMP		Rat	PMID:32231239|RGD:32716373
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	CYP27B1	IMP		Human	PMID:12496369
Biological Process	GO:2000830	positive regulation of parathyroid hormone secretion	Cyp27b1	IMP		Rat	PMID:32231239|RGD:32716373
Biological Process	GO:0010980	positive regulation of vitamin D 24-hydroxylase activity	CYP27B1	IDA		Human	PMID:16549446
Biological Process	GO:0070564	positive regulation of vitamin D receptor signaling pathway	CYP27B1	IDA		Human	PMID:16549446
Biological Process	GO:0030500	regulation of bone mineralization	CYP27B1	IMP		Human	PMID:9415400
Biological Process	GO:0051592	response to calcium ion	Cyp27b1	IEP		Rat	PMID:8333523|RGD:2307320
Biological Process	GO:0051591	response to cAMP	Cyp27b1	IDA		Rat	PMID:6282936|RGD:2307324
Biological Process	GO:0046688	response to copper ion	Cyp27b1	IDA		Rat	PMID:3348368|RGD:2307322
Biological Process	GO:0043627	response to estrogen	CYP27B1	IEP		Human	PMID:15795327
Biological Process	GO:0032868	response to insulin	Cyp27b1	IDA		Rat	PMID:3295473|RGD:2307313
Biological Process	GO:0032496	response to lipopolysaccharide	CYP27B1	IDA		Human	PMID:12855575
Biological Process	GO:0043434	response to peptide hormone	Cyp27b1	IEP		Rat	PMID:10393981|RGD:2307327
Biological Process	GO:0043434	response to peptide hormone	Cyp27b1	IEP		Rat	PMID:17223550|RGD:2307315
Biological Process	GO:0034695	response to prostaglandin E	Cyp27b1	IDA		Rat	PMID:3937586|RGD:2307314
Biological Process	GO:0034341	response to type II interferon	CYP27B1	IDA		Human	PMID:9282826
Biological Process	GO:0033280	response to vitamin D	CYP27B1	IDA		Human	PMID:16549446
Biological Process	GO:0033280	response to vitamin D	Cyp27b1	IDA		Mouse	MGI:MGI:1097206|PMID:9295274
Biological Process	GO:0033280	response to vitamin D	Cyp27b1	IDA		Rat	PMID:3000565|RGD:2307325
Biological Process	GO:0009410	response to xenobiotic stimulus	Cyp27b1	IDA		Rat	PMID:3937586|RGD:2307314
Biological Process	GO:0042369	vitamin D catabolic process	Cyp27b1	IDA		Mouse	MGI:MGI:1097206|PMID:9295274
Biological Process	GO:0042369	vitamin D catabolic process	Cyp27b1	IDA		Rat	PMID:9333115|RGD:69373
Biological Process	GO:0042359	vitamin D metabolic process	CYP27B1	IDA		Human	PMID:9415400
Biological Process	GO:0042359	vitamin D metabolic process	Cyp27b1	IDA		Rat	PMID:9371776|RGD:69372

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern