Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP2B6
  • Mouse genes Cyp2b10
  • Rat genes Cyp2b1,Cyp2b2
  • Zfish genes cyp2y3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp2b10

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0062188	anandamide 11,12 epoxidase activity	CYP2B6	IDA		Human	PMID:21289075
Molecular Function	GO:0062189	anandamide 14,15 epoxidase activity	CYP2B6	IDA		Human	PMID:21289075
Molecular Function	GO:0062187	anandamide 8,9 epoxidase activity	CYP2B6	IDA		Human	PMID:21289075
Molecular Function	GO:0101021	estrogen 2-hydroxylase activity	CYP2B6	IDA		Human	PMID:12865317
Molecular Function	GO:0020037	heme binding	CYP2B6	IDA		Human	PMID:20061448
Molecular Function	GO:0030544	Hsp70 protein binding	Cyp2b1	IDA		Rat	PMID:19401463|RGD:13838795
Molecular Function	GO:0051879	Hsp90 protein binding	Cyp2b1	IDA		Rat	PMID:19401463|RGD:13838795
Molecular Function	GO:0004497	monooxygenase activity	CYP2B6	IDA		Human	PMID:19651758
Molecular Function	GO:0016491	oxidoreductase activity	Cyp2b2	IDA		Rat	PMID:9425052|RGD:2301461
Molecular Function	GO:0008395	steroid hydroxylase activity	Cyp2b1	IDA		Rat	PMID:7979377|RGD:2301460
Molecular Function	GO:0008395	steroid hydroxylase activity	Cyp2b2	IDA		Rat	PMID:2574176|RGD:2301462
Molecular Function	GO:0008390	testosterone 16-alpha-hydroxylase activity	CYP2B6	IDA		Human	PMID:21289075
Molecular Function	GO:0062184	testosterone 16-beta-hydroxylase activity	CYP2B6	IDA		Human	PMID:21289075
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Cyp2b1	IDA		Rat	PMID:17015271|RGD:2301459
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Cyp2b2	IDA		Rat	PMID:16937917|RGD:2301463
Cellular Component	GO:0005743	mitochondrial inner membrane	Cyp2b1	IDA		Rat	PMID:19401463|RGD:13838795
Biological Process	GO:0007568	aging	Cyp2b2	IEP		Rat	PMID:18653662|RGD:2301454
Biological Process	GO:0042180	cellular ketone metabolic process	CYP2B6	IDA		Human	PMID:19651758
Biological Process	GO:0018933	nicotine metabolic process	Cyp2b2	IEP		Rat	PMID:11996101|RGD:1298848
Biological Process	GO:0009617	response to bacterium	Cyp2b10	IEP		Mouse	PMID:23012479
Biological Process	GO:0051592	response to calcium ion	Cyp2b1	IEP		Rat	PMID:10454523|RGD:2301464
Biological Process	GO:0051592	response to calcium ion	Cyp2b2	IEP		Rat	PMID:10454523|RGD:2301464
Biological Process	GO:0032868	response to insulin	Cyp2b1	IEP		Rat	PMID:17015271|RGD:2301459
Biological Process	GO:0010038	response to metal ion	Cyp2b1	IEP		Rat	PMID:18202523|RGD:2301456
Biological Process	GO:0010038	response to metal ion	Cyp2b2	IEP		Rat	PMID:18202523|RGD:2301456
Biological Process	GO:0014070	response to organic cyclic compound	Cyp2b1	IEP		Rat	PMID:18670162|RGD:2301453
Biological Process	GO:0014070	response to organic cyclic compound	Cyp2b2	IEP		Rat	PMID:18670162|RGD:2301453
Biological Process	GO:0010477	response to sulfur dioxide	Cyp2b1	IEP		Rat	PMID:17086701|RGD:2301458
Biological Process	GO:0009410	response to xenobiotic stimulus	Cyp2b1	IEP		Rat	PMID:18798224|RGD:2301452
Biological Process	GO:0008202	steroid metabolic process	CYP2B6	IMP		Human	PMID:18356043
Biological Process	GO:0042178	xenobiotic catabolic process	CYP2B6	IDA		Human	PMID:19029318
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2B6	IMP		Human	PMID:18356043
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2B6	IDA		Human	PMID:19651758
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2B6	IDA		Human	PMID:20061448
Biological Process	GO:0006805	xenobiotic metabolic process	Cyp2b1	IDA		Rat	PMID:9425052|RGD:2301461
Biological Process	GO:0006805	xenobiotic metabolic process	Cyp2b2	IDA		Rat	PMID:9425052|RGD:2301461

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern