Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP2C18,CYP2C19,CYP2C8,CYP2C9
  • Mouse genes Cyp2c39
  • Rat genes Cyp2c7,LOC100361547
  • Zfish genes cyp2y3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp2c39

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008405	arachidonic acid 11,12-epoxygenase activity	Cyp2c39	IDA		Mouse	MGI:MGI:1277710|PMID:9721182
Molecular Function	GO:0008392	arachidonic acid epoxygenase activity	CYP2C8	IDA		Human	PMID:7574697
Molecular Function	GO:0008392	arachidonic acid epoxygenase activity	CYP2C9	IDA		Human	PMID:7574697
Molecular Function	GO:0034875	caffeine oxidase activity	CYP2C8	IDA		Human	PMID:18619574
Molecular Function	GO:0034875	caffeine oxidase activity	CYP2C9	IDA		Human	PMID:18619574
Molecular Function	GO:0019899	enzyme binding	CYP2C19	IPI	UniProtKB:P00388	Human	PMID:15680923
Molecular Function	GO:0101020	estrogen 16-alpha-hydroxylase activity	CYP2C8	IDA		Human	PMID:14559847
Molecular Function	GO:0020037	heme binding	CYP2C19	IDA		Human	PMID:23118231
Molecular Function	GO:0120319	long-chain fatty acid omega-1 hydroxylase activity	CYP2C19	IDA		Human	PMID:18577768
Molecular Function	GO:0004497	monooxygenase activity	CYP2C8	IDA		Human	PMID:15766564
Molecular Function	GO:0004497	monooxygenase activity	CYP2C8	IDA		Human	PMID:19651758
Molecular Function	GO:0004497	monooxygenase activity	CYP2C9	IDA		Human	PMID:15766564
Molecular Function	GO:0004497	monooxygenase activity	CYP2C9	IDA		Human	PMID:19651758
Molecular Function	GO:0004497	monooxygenase activity	CYP2C19	IDA		Human	PMID:19651758
Molecular Function	GO:0016491	oxidoreductase activity	CYP2C9	IDA		Human	PMID:16401082
Molecular Function	GO:0016491	oxidoreductase activity	CYP2C9	IDA		Human	PMID:19219744
Molecular Function	GO:0016491	oxidoreductase activity	CYP2C19	IDA		Human	PMID:16401082
Molecular Function	GO:0016491	oxidoreductase activity	CYP2C19	IDA		Human	PMID:19219744
Molecular Function	GO:0005515	protein binding	CYP2C8	IPI	UniProtKB:O75400-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYP2C8	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYP2C8	IPI	UniProtKB:Q9Y371	Human	PMID:32814053
Molecular Function	GO:0008401	retinoic acid 4-hydroxylase activity	CYP2C8	IDA		Human	PMID:11093772
Molecular Function	GO:0008401	retinoic acid 4-hydroxylase activity	CYP2C18	IDA		Human	PMID:11093772
Molecular Function	GO:0008395	steroid hydroxylase activity	CYP2C9	IMP		Human	PMID:18356043
Molecular Function	GO:0008395	steroid hydroxylase activity	CYP2C19	IMP		Human	PMID:18356043
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CYP2C8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CYP2C9	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CYP2C9	IDA		Human	PMID:9618440
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CYP2C18	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CYP2C19	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Cyp2c7	IDA		Rat	PMID:15363580|RGD:2301471
Cellular Component	GO:0005886	plasma membrane	CYP2C8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CYP2C9	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CYP2C18	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CYP2C19	IDA		Human	GO_REF:0000052
Biological Process	GO:0043603	amide metabolic process	CYP2C9	IDA		Human	PMID:19651758
Biological Process	GO:0019369	arachidonic acid metabolic process	Cyp2c39	IDA		Mouse	MGI:MGI:1277710|PMID:9721182
Biological Process	GO:0019373	epoxygenase P450 pathway	CYP2C8	IDA		Human	PMID:7574697
Biological Process	GO:0019373	epoxygenase P450 pathway	CYP2C9	IDA		Human	PMID:7574697
Biological Process	GO:0008210	estrogen metabolic process	CYP2C8	IDA		Human	PMID:12865317
Biological Process	GO:0008210	estrogen metabolic process	CYP2C8	IDA		Human	PMID:14559847
Biological Process	GO:0008210	estrogen metabolic process	CYP2C9	IDA		Human	PMID:12865317
Biological Process	GO:0046483	heterocycle metabolic process	CYP2C19	IDA		Human	PMID:19651758
Biological Process	GO:0046456	icosanoid biosynthetic process	CYP2C8	IDA		Human	PMID:15766564
Biological Process	GO:0046456	icosanoid biosynthetic process	CYP2C9	IDA		Human	PMID:15766564
Biological Process	GO:0002933	lipid hydroxylation	CYP2C8	IDA		Human	PMID:14559847
Biological Process	GO:0001676	long-chain fatty acid metabolic process	CYP2C19	IDA		Human	PMID:18577768
Biological Process	GO:0032787	monocarboxylic acid metabolic process	CYP2C9	IDA		Human	PMID:19651758
Biological Process	GO:0016098	monoterpenoid metabolic process	CYP2C9	IDA		Human	PMID:16401082
Biological Process	GO:0016098	monoterpenoid metabolic process	CYP2C19	IDA		Human	PMID:16401082
Biological Process	GO:0006082	organic acid metabolic process	CYP2C8	IDA		Human	PMID:19651758
Biological Process	GO:0070989	oxidative demethylation	CYP2C8	IDA		Human	PMID:18619574
Biological Process	GO:0070989	oxidative demethylation	CYP2C9	IDA		Human	PMID:18619574
Biological Process	GO:0045471	response to ethanol	Cyp2c7	IEP		Rat	PMID:10660124|RGD:2301472
Biological Process	GO:0032496	response to lipopolysaccharide	Cyp2c7	IEP		Rat	PMID:8435092|RGD:2301476
Biological Process	GO:0007584	response to nutrient	Cyp2c7	IEP		Rat	PMID:8534269|RGD:2301474
Biological Process	GO:0014070	response to organic cyclic compound	Cyp2c7	IEP		Rat	PMID:8471063|RGD:2301475
Biological Process	GO:0010243	response to organonitrogen compound	Cyp2c7	IEP		Rat	PMID:1370375|RGD:2301477
Biological Process	GO:0043434	response to peptide hormone	Cyp2c7	IEP		Rat	PMID:10660124|RGD:2301472
Biological Process	GO:0032526	response to retinoic acid	Cyp2c7	IEP		Rat	PMID:9202400|RGD:2301473
Biological Process	GO:0009410	response to xenobiotic stimulus	Cyp2c7	IEP		Rat	PMID:15634872|RGD:2301470
Biological Process	GO:0042573	retinoic acid metabolic process	CYP2C8	IDA		Human	PMID:11093772
Biological Process	GO:0042573	retinoic acid metabolic process	CYP2C18	IDA		Human	PMID:11093772
Biological Process	GO:0008202	steroid metabolic process	CYP2C8	IDA		Human	PMID:14559847
Biological Process	GO:0008202	steroid metabolic process	CYP2C9	IMP		Human	PMID:18356043
Biological Process	GO:0008202	steroid metabolic process	CYP2C19	IMP		Human	PMID:18356043
Biological Process	GO:0019627	urea metabolic process	CYP2C9	IDA		Human	PMID:19029318
Biological Process	GO:0042178	xenobiotic catabolic process	CYP2C8	IDA		Human	PMID:18619574
Biological Process	GO:0042178	xenobiotic catabolic process	CYP2C9	IMP		Human	PMID:18356043
Biological Process	GO:0042178	xenobiotic catabolic process	CYP2C9	IDA		Human	PMID:18619574
Biological Process	GO:0042178	xenobiotic catabolic process	CYP2C19	IDA		Human	PMID:19029318
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2C8	IDA		Human	PMID:19651758
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2C9	IDA		Human	PMID:19219744
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2C9	IDA		Human	PMID:19651758
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2C9	IMP		Human	PMID:21127708
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2C19	IDA		Human	PMID:19219744
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2C19	IDA		Human	PMID:19651758

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern