Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP2C8,CYP2C9
  • Mouse genes Cyp2c66
  • Rat genes LOC100912265
  • Zfish genes cyp2y3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp2c66

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008392	arachidonic acid epoxygenase activity	CYP2C8	IDA		Human	PMID:7574697
Molecular Function	GO:0008392	arachidonic acid epoxygenase activity	CYP2C9	IDA		Human	PMID:7574697
Molecular Function	GO:0034875	caffeine oxidase activity	CYP2C8	IDA		Human	PMID:18619574
Molecular Function	GO:0034875	caffeine oxidase activity	CYP2C9	IDA		Human	PMID:18619574
Molecular Function	GO:0101020	estrogen 16-alpha-hydroxylase activity	CYP2C8	IDA		Human	PMID:14559847
Molecular Function	GO:0004497	monooxygenase activity	CYP2C8	IDA		Human	PMID:15766564
Molecular Function	GO:0004497	monooxygenase activity	CYP2C8	IDA		Human	PMID:19651758
Molecular Function	GO:0004497	monooxygenase activity	CYP2C9	IDA		Human	PMID:15766564
Molecular Function	GO:0004497	monooxygenase activity	CYP2C9	IDA		Human	PMID:19651758
Molecular Function	GO:0016491	oxidoreductase activity	CYP2C9	IDA		Human	PMID:16401082
Molecular Function	GO:0016491	oxidoreductase activity	CYP2C9	IDA		Human	PMID:19219744
Molecular Function	GO:0005515	protein binding	CYP2C8	IPI	UniProtKB:O75400-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYP2C8	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYP2C8	IPI	UniProtKB:Q9Y371	Human	PMID:32814053
Molecular Function	GO:0008401	retinoic acid 4-hydroxylase activity	CYP2C8	IDA		Human	PMID:11093772
Molecular Function	GO:0008395	steroid hydroxylase activity	CYP2C9	IMP		Human	PMID:18356043
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CYP2C8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CYP2C9	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CYP2C9	IDA		Human	PMID:9618440
Cellular Component	GO:0005886	plasma membrane	CYP2C8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CYP2C9	IDA		Human	GO_REF:0000052
Biological Process	GO:0043603	amide metabolic process	CYP2C9	IDA		Human	PMID:19651758
Biological Process	GO:0019373	epoxygenase P450 pathway	CYP2C8	IDA		Human	PMID:7574697
Biological Process	GO:0019373	epoxygenase P450 pathway	CYP2C9	IDA		Human	PMID:7574697
Biological Process	GO:0008210	estrogen metabolic process	CYP2C8	IDA		Human	PMID:12865317
Biological Process	GO:0008210	estrogen metabolic process	CYP2C8	IDA		Human	PMID:14559847
Biological Process	GO:0008210	estrogen metabolic process	CYP2C9	IDA		Human	PMID:12865317
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Cyp2c66	IGI	MGI:MGI:1343184	Mouse	PMID:24029230
Biological Process	GO:0046456	icosanoid biosynthetic process	CYP2C8	IDA		Human	PMID:15766564
Biological Process	GO:0046456	icosanoid biosynthetic process	CYP2C9	IDA		Human	PMID:15766564
Biological Process	GO:0002933	lipid hydroxylation	CYP2C8	IDA		Human	PMID:14559847
Biological Process	GO:0032787	monocarboxylic acid metabolic process	CYP2C9	IDA		Human	PMID:19651758
Biological Process	GO:0016098	monoterpenoid metabolic process	CYP2C9	IDA		Human	PMID:16401082
Biological Process	GO:0006082	organic acid metabolic process	CYP2C8	IDA		Human	PMID:19651758
Biological Process	GO:0070989	oxidative demethylation	CYP2C8	IDA		Human	PMID:18619574
Biological Process	GO:0070989	oxidative demethylation	CYP2C9	IDA		Human	PMID:18619574
Biological Process	GO:0042573	retinoic acid metabolic process	CYP2C8	IDA		Human	PMID:11093772
Biological Process	GO:0008202	steroid metabolic process	CYP2C8	IDA		Human	PMID:14559847
Biological Process	GO:0008202	steroid metabolic process	CYP2C9	IMP		Human	PMID:18356043
Biological Process	GO:0019627	urea metabolic process	CYP2C9	IDA		Human	PMID:19029318
Biological Process	GO:0042178	xenobiotic catabolic process	CYP2C8	IDA		Human	PMID:18619574
Biological Process	GO:0042178	xenobiotic catabolic process	CYP2C9	IMP		Human	PMID:18356043
Biological Process	GO:0042178	xenobiotic catabolic process	CYP2C9	IDA		Human	PMID:18619574
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2C8	IDA		Human	PMID:19651758
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2C9	IDA		Human	PMID:19219744
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2C9	IDA		Human	PMID:19651758
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2C9	IMP		Human	PMID:21127708

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern