Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP2D6,CYP2D7
  • Mouse genes Cyp2d40
  • Rat genes Cyp2d3
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp2d40

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0062188	anandamide 11,12 epoxidase activity	CYP2D6	IDA		Human	PMID:21289075
Molecular Function	GO:0062189	anandamide 14,15 epoxidase activity	CYP2D6	IDA		Human	PMID:21289075
Molecular Function	GO:0062187	anandamide 8,9 epoxidase activity	CYP2D6	IDA		Human	PMID:21289075
Molecular Function	GO:0070330	aromatase activity	CYP2D7	IDA		Human	PMID:15051713
Molecular Function	GO:0020037	heme binding	CYP2D6	IDA		Human	PMID:16352597
Molecular Function	GO:0004497	monooxygenase activity	CYP2D6	IDA		Human	PMID:15327587
Molecular Function	GO:0004497	monooxygenase activity	CYP2D6	IDA		Human	PMID:19651758
Molecular Function	GO:0004497	monooxygenase activity	Cyp2d3	IDA		Rat	PMID:9434752|RGD:728361
Molecular Function	GO:0016491	oxidoreductase activity	CYP2D6	IDA		Human	PMID:15039299
Molecular Function	GO:0016491	oxidoreductase activity	CYP2D6	IDA		Human	PMID:16401082
Molecular Function	GO:0016491	oxidoreductase activity	CYP2D6	IDA		Human	PMID:19219744
Cellular Component	GO:0005737	cytoplasm	CYP2D7	IDA		Human	PMID:15051713
Cellular Component	GO:0005739	mitochondrion	CYP2D7	IDA		Human	PMID:18838503
Cellular Component	GO:0005739	mitochondrion	CYP2D6	IDA		Human	PMID:19438707
Biological Process	GO:0009822	alkaloid catabolic process	CYP2D6	IDA		Human	PMID:15039299
Biological Process	GO:0009820	alkaloid metabolic process	CYP2D6	IDA		Human	PMID:19651758
Biological Process	GO:0009804	coumarin metabolic process	CYP2D6	IDA		Human	PMID:19438707
Biological Process	GO:0008210	estrogen metabolic process	CYP2D6	IDA		Human	PMID:12865317
Biological Process	GO:0046483	heterocycle metabolic process	CYP2D6	IDA		Human	PMID:15327587
Biological Process	GO:0046483	heterocycle metabolic process	CYP2D6	IDA		Human	PMID:19651758
Biological Process	GO:0033076	isoquinoline alkaloid metabolic process	CYP2D6	IDA		Human	PMID:19448135
Biological Process	GO:0001889	liver development	Cyp2d3	IEP		Rat	PMID:9929501|RGD:2301678
Biological Process	GO:0016098	monoterpenoid metabolic process	CYP2D6	IDA		Human	PMID:16401082
Biological Process	GO:0051100	negative regulation of binding	CYP2D6	IDA		Human	PMID:19448135
Biological Process	GO:0090350	negative regulation of cellular organofluorine metabolic process	CYP2D6	IDA		Human	PMID:19448135
Biological Process	GO:0070989	oxidative demethylation	CYP2D6	IDA		Human	PMID:15039299
Biological Process	GO:0070989	oxidative demethylation	CYP2D6	IDA		Human	PMID:19438707
Biological Process	GO:0042572	retinol metabolic process	CYP2D6	IDA		Human	PMID:10681376
Biological Process	GO:0008202	steroid metabolic process	CYP2D6	IMP		Human	PMID:18356043
Biological Process	GO:0042178	xenobiotic catabolic process	CYP2D7	IDA		Human	PMID:15051713
Biological Process	GO:0042178	xenobiotic catabolic process	CYP2D6	IDA		Human	PMID:15039299
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2D7	IDA		Human	PMID:15051713
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2D6	IMP		Human	PMID:18356043
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2D6	IDA		Human	PMID:19219744

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern