Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP2E1
  • Mouse genes Cyp2e1
  • Rat genes Cyp2e1
  • Zfish genes cyp2y3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp2e1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0018601	4-nitrophenol 2-monooxygenase activity	CYP2E1	IDA		Human	PMID:9348445
Molecular Function	GO:0019899	enzyme binding	CYP2E1	IPI	UniProtKB:P00167	Human	PMID:15680923
Molecular Function	GO:0019899	enzyme binding	CYP2E1	IPI	UniProtKB:P00388	Human	PMID:15680923
Molecular Function	GO:0020037	heme binding	CYP2E1	IDA		Human	PMID:18818195
Molecular Function	GO:0030544	Hsp70 protein binding	Cyp2e1	IDA		Rat	PMID:19401463|RGD:13838795
Molecular Function	GO:0051879	Hsp90 protein binding	Cyp2e1	IDA		Rat	PMID:19401463|RGD:13838795
Molecular Function	GO:0120319	long-chain fatty acid omega-1 hydroxylase activity	CYP2E1	IDA		Human	PMID:18577768
Molecular Function	GO:0004497	monooxygenase activity	CYP2E1	IDA		Human	PMID:10553002
Molecular Function	GO:0004497	monooxygenase activity	CYP2E1	IDA		Human	PMID:19651758
Molecular Function	GO:0004497	monooxygenase activity	Cyp2e1	IDA		Mouse	PMID:14642533
Molecular Function	GO:0016491	oxidoreductase activity	CYP2E1	IDA		Human	PMID:16401082
Molecular Function	GO:0016491	oxidoreductase activity	CYP2E1	IDA		Human	PMID:19219744
Cellular Component	GO:0005783	endoplasmic reticulum	Cyp2e1	IDA		Mouse	PMID:16223484
Cellular Component	GO:0005783	endoplasmic reticulum	Cyp2e1	IDA		Rat	PMID:14661969|RGD:1626310
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Cyp2e1	IDA		Rat	PMID:19401463|RGD:13838795
Cellular Component	GO:0000139	Golgi membrane	Cyp2e1	IDA		Rat	PMID:8809087|RGD:1626303
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Cyp2e1	IDA		Rat	PMID:12220509|RGD:625597
Cellular Component	GO:0005743	mitochondrial inner membrane	Cyp2e1	IDA		Rat	PMID:19401463|RGD:13838795
Cellular Component	GO:0005739	mitochondrion	Cyp2e1	IDA		Rat	PMID:16337197|RGD:1626309
Biological Process	GO:0018960	4-nitrophenol metabolic process	CYP2E1	IDA		Human	PMID:9348445
Biological Process	GO:0046483	heterocycle metabolic process	CYP2E1	IDA		Human	PMID:19651758
Biological Process	GO:0002933	lipid hydroxylation	CYP2E1	IDA		Human	PMID:10553002
Biological Process	GO:0001676	long-chain fatty acid metabolic process	CYP2E1	IDA		Human	PMID:18577768
Biological Process	GO:0016098	monoterpenoid metabolic process	CYP2E1	IDA		Human	PMID:16401082
Biological Process	GO:0009617	response to bacterium	Cyp2e1	IEP		Mouse	PMID:23012479
Biological Process	GO:0045471	response to ethanol	Cyp2e1	IEP		Rat	PMID:16337197|RGD:1626309
Biological Process	GO:0010243	response to organonitrogen compound	Cyp2e1	IEP		Rat	PMID:19406192|RGD:2313683
Biological Process	GO:0010193	response to ozone	Cyp2e1	IEP		Rat	PMID:9571988|RGD:4892221
Biological Process	GO:0009410	response to xenobiotic stimulus	Cyp2e1	IEP		Rat	PMID:21170329|RGD:4892234
Biological Process	GO:0008202	steroid metabolic process	CYP2E1	IMP		Human	PMID:18356043
Biological Process	GO:0006641	triglyceride metabolic process	Cyp2e1	IMP		Rat	PMID:20116195|RGD:2317269
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2E1	IMP		Human	PMID:18356043
Biological Process	GO:0006805	xenobiotic metabolic process	CYP2E1	IDA		Human	PMID:19219744
Biological Process	GO:0006805	xenobiotic metabolic process	Cyp2e1	IMP		Rat	PMID:21187827|RGD:4892233

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern