Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP2R1
  • Mouse genes Cyp2r1
  • Rat genes Cyp2r1
  • Zfish genes cyp2r1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp2r1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1902271	D3 vitamins binding	CYP2R1	IDA		Human	PMID:18511070
Molecular Function	GO:0020037	heme binding	CYP2R1	IDA		Human	PMID:18511070
Molecular Function	GO:0005506	iron ion binding	CYP2R1	IDA		Human	PMID:18511070
Molecular Function	GO:0042803	protein homodimerization activity	CYP2R1	IDA		Human	PMID:18511070
Molecular Function	GO:0030343	vitamin D3 25-hydroxylase activity	CYP2R1	IDA		Human	PMID:15465040
Molecular Function	GO:0030343	vitamin D3 25-hydroxylase activity	CYP2R1	IDA		Human	PMID:18511070
Molecular Function	GO:0030343	vitamin D3 25-hydroxylase activity	Cyp2r1	IDA		Mouse	PMID:12867411
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Cyp2r1	IDA		Rat	PMID:15585593|RGD:2315689
Biological Process	GO:0036378	calcitriol biosynthetic process from calciol	CYP2R1	IDA		Human	PMID:15465040
Biological Process	GO:0036378	calcitriol biosynthetic process from calciol	CYP2R1	IDA		Human	PMID:18511070
Biological Process	GO:0036378	calcitriol biosynthetic process from calciol	Cyp2r1	IDA		Mouse	MGI:MGI:2677973|PMID:12867411
Biological Process	GO:0071305	cellular response to vitamin D	cyp2r1	IMP	ZFIN:ZDB-MRPHLNO-161129-8,ZFIN:ZDB-MRPHLNO-161129-9	Zfish	PMID:26365513
Biological Process	GO:0071425	hematopoietic stem cell proliferation	cyp2r1	IMP	ZFIN:ZDB-GENO-171005-11	Zfish	PMID:26365513
Biological Process	GO:0071425	hematopoietic stem cell proliferation	cyp2r1	IMP	ZFIN:ZDB-MRPHLNO-161129-8,ZFIN:ZDB-MRPHLNO-161129-9	Zfish	PMID:26365513
Biological Process	GO:0010164	response to cesium ion	Cyp2r1	IEP		Rat	PMID:16806633|RGD:1601035
Biological Process	GO:0010212	response to ionizing radiation	Cyp2r1	IEP		Rat	PMID:16806633|RGD:1601035
Biological Process	GO:0010038	response to metal ion	Cyp2r1	IEP		Rat	PMID:16502312|RGD:1601036
Biological Process	GO:0042359	vitamin D metabolic process	Cyp2r1	IDA		Mouse	PMID:12867411
Biological Process	GO:0070640	vitamin D3 metabolic process	cyp2r1	IMP	ZFIN:ZDB-GENO-180305-2	Zfish	PMID:28514663

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern