Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP3A4,CYP3A5,CYP3A7,CYP3A7-CYP3A51P
  • Mouse genes Cyp3a13
  • Rat genes Cyp3a9
  • Zfish genes cyp3a65,cyp3c1,cyp3c3,cyp3c4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp3a13

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0062181	1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity	CYP3A4	IDA		Human	PMID:29461981
Molecular Function	GO:0034875	caffeine oxidase activity	CYP3A4	IDA		Human	PMID:18619574
Molecular Function	GO:0019899	enzyme binding	CYP3A4	IPI	UniProtKB:P00167	Human	PMID:15680923
Molecular Function	GO:0101020	estrogen 16-alpha-hydroxylase activity	CYP3A4	IDA		Human	PMID:11555828
Molecular Function	GO:0101020	estrogen 16-alpha-hydroxylase activity	CYP3A4	IDA		Human	PMID:14559847
Molecular Function	GO:0101020	estrogen 16-alpha-hydroxylase activity	CYP3A5	IDA		Human	PMID:14559847
Molecular Function	GO:0101020	estrogen 16-alpha-hydroxylase activity	CYP3A7	IDA		Human	PMID:14559847
Molecular Function	GO:0101021	estrogen 2-hydroxylase activity	CYP3A4	IDA		Human	PMID:12865317
Molecular Function	GO:0101021	estrogen 2-hydroxylase activity	CYP3A7	IDA		Human	PMID:12865317
Molecular Function	GO:0020037	heme binding	cyp3c1	IDA		Zfish	PMID:16414346
Molecular Function	GO:0005506	iron ion binding	CYP3A4	IDA		Human	PMID:15256616
Molecular Function	GO:0004497	monooxygenase activity	CYP3A4	IDA		Human	PMID:15327587
Molecular Function	GO:0016491	oxidoreductase activity	CYP3A4	IDA		Human	PMID:15039299
Molecular Function	GO:0016491	oxidoreductase activity	CYP3A4	IDA		Human	PMID:16401082
Molecular Function	GO:0016491	oxidoreductase activity	CYP3A4	IDA		Human	PMID:19219744
Molecular Function	GO:0016491	oxidoreductase activity	CYP3A5	IDA		Human	PMID:15039299
Molecular Function	GO:0005515	protein binding	CYP3A4	IPI	UniProtKB:O00264	Human	PMID:26988023
Molecular Function	GO:0005515	protein binding	CYP3A4	IPI	UniProtKB:O15287	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYP3A4	IPI	UniProtKB:Q6ZQX7-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CYP3A5	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0008401	retinoic acid 4-hydroxylase activity	CYP3A4	IDA		Human	PMID:11093772
Molecular Function	GO:0008401	retinoic acid 4-hydroxylase activity	CYP3A5	IDA		Human	PMID:11093772
Molecular Function	GO:0008401	retinoic acid 4-hydroxylase activity	CYP3A7	IDA		Human	PMID:11093772
Molecular Function	GO:0005496	steroid binding	CYP3A4	IDA		Human	PMID:15256616
Molecular Function	GO:0008395	steroid hydroxylase activity	CYP3A4	IMP		Human	PMID:18356043
Molecular Function	GO:0008395	steroid hydroxylase activity	CYP3A7	IDA		Human	PMID:14559847
Molecular Function	GO:0050649	testosterone 6-beta-hydroxylase activity	CYP3A4	IMP		Human	PMID:3259858
Molecular Function	GO:0070576	vitamin D 24-hydroxylase activity	CYP3A4	IDA		Human	PMID:15546903
Molecular Function	GO:0030343	vitamin D3 25-hydroxylase activity	CYP3A4	IDA		Human	PMID:15546903
Cellular Component	GO:0005737	cytoplasm	CYP3A4	IDA		Human	PMID:18446064
Biological Process	GO:0009822	alkaloid catabolic process	CYP3A4	IDA		Human	PMID:15039299
Biological Process	GO:0009822	alkaloid catabolic process	CYP3A5	IDA		Human	PMID:15039299
Biological Process	GO:0008210	estrogen metabolic process	CYP3A4	IDA		Human	PMID:11555828
Biological Process	GO:0008210	estrogen metabolic process	CYP3A4	IDA		Human	PMID:12865317
Biological Process	GO:0008210	estrogen metabolic process	CYP3A4	IDA		Human	PMID:14559847
Biological Process	GO:0008210	estrogen metabolic process	CYP3A5	IDA		Human	PMID:12865317
Biological Process	GO:0008210	estrogen metabolic process	CYP3A7	IDA		Human	PMID:12865317
Biological Process	GO:0008210	estrogen metabolic process	CYP3A7	IDA		Human	PMID:14559847
Biological Process	GO:0007565	female pregnancy	Cyp3a9	IEP		Rat	PMID:12606633|RGD:1299416
Biological Process	GO:0046483	heterocycle metabolic process	CYP3A4	IDA		Human	PMID:15327587
Biological Process	GO:0002933	lipid hydroxylation	CYP3A4	IDA		Human	PMID:14559847
Biological Process	GO:0002933	lipid hydroxylation	CYP3A5	IDA		Human	PMID:14559847
Biological Process	GO:0002933	lipid hydroxylation	CYP3A7	IDA		Human	PMID:14559847
Biological Process	GO:0016098	monoterpenoid metabolic process	CYP3A4	IDA		Human	PMID:16401082
Biological Process	GO:0070989	oxidative demethylation	CYP3A4	IDA		Human	PMID:15039299
Biological Process	GO:0070989	oxidative demethylation	CYP3A4	IDA		Human	PMID:18619574
Biological Process	GO:0070989	oxidative demethylation	CYP3A5	IDA		Human	PMID:15039299
Biological Process	GO:0010628	positive regulation of gene expression	Cyp3a13	IMP	MGI:MGI:3764486	Mouse	PMID:18794335
Biological Process	GO:0071548	response to dexamethasone	Cyp3a9	IEP		Rat	PMID:8990268|RGD:11353812
Biological Process	GO:0032355	response to estradiol	Cyp3a9	IEP		Rat	PMID:10570034|RGD:11353816
Biological Process	GO:0043627	response to estrogen	Cyp3a9	IEP		Rat	PMID:9264551|RGD:11353813
Biological Process	GO:0045471	response to ethanol	Cyp3a9	IEP		Rat	PMID:11046114|RGD:11353817
Biological Process	GO:0009410	response to xenobiotic stimulus	cyp3a65	IDA		Zfish	PMID:15922010
Biological Process	GO:0010043	response to zinc ion	Cyp3a9	IEP		Rat	PMID:11705462|RGD:11353814
Biological Process	GO:0042573	retinoic acid metabolic process	CYP3A4	IDA		Human	PMID:11093772
Biological Process	GO:0042573	retinoic acid metabolic process	CYP3A5	IDA		Human	PMID:11093772
Biological Process	GO:0042573	retinoic acid metabolic process	CYP3A7	IDA		Human	PMID:11093772
Biological Process	GO:0042572	retinol metabolic process	CYP3A4	IDA		Human	PMID:10681376
Biological Process	GO:0006706	steroid catabolic process	CYP3A4	IMP		Human	PMID:18356043
Biological Process	GO:0008202	steroid metabolic process	CYP3A4	IDA		Human	PMID:14559847
Biological Process	GO:0008202	steroid metabolic process	CYP3A4	IMP		Human	PMID:3259858
Biological Process	GO:0008202	steroid metabolic process	CYP3A5	IDA		Human	PMID:14559847
Biological Process	GO:0008202	steroid metabolic process	CYP3A7	IDA		Human	PMID:14559847
Biological Process	GO:0042369	vitamin D catabolic process	CYP3A4	IDA		Human	PMID:29461981
Biological Process	GO:0042178	xenobiotic catabolic process	CYP3A4	IDA		Human	PMID:15039299
Biological Process	GO:0042178	xenobiotic catabolic process	CYP3A4	IMP		Human	PMID:18356043
Biological Process	GO:0042178	xenobiotic catabolic process	CYP3A4	IDA		Human	PMID:18619574
Biological Process	GO:0042178	xenobiotic catabolic process	CYP3A5	IDA		Human	PMID:15039299
Biological Process	GO:0006805	xenobiotic metabolic process	CYP3A4	IDA		Human	PMID:15327587
Biological Process	GO:0006805	xenobiotic metabolic process	CYP3A4	IDA		Human	PMID:19219744

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern