Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP3A5
  • Mouse genes Cyp3a41a
  • Rat genes Cyp3a2,Cyp3a23-3a1
  • Zfish genes cyp3a65,cyp3c1,cyp3c3,cyp3c4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp3a41a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0032451	demethylase activity	Cyp3a23-3a1	IDA		Rat	PMID:12971802|RGD:5129544
Molecular Function	GO:0032451	demethylase activity	Cyp3a23-3a1	IDA		Rat	PMID:18057719|RGD:2301699
Molecular Function	GO:0032451	demethylase activity	Cyp3a2	IDA		Rat	PMID:12971802|RGD:5129544
Molecular Function	GO:0101020	estrogen 16-alpha-hydroxylase activity	CYP3A5	IDA		Human	PMID:14559847
Molecular Function	GO:0020037	heme binding	cyp3c1	IDA		Zfish	PMID:16414346
Molecular Function	GO:0004497	monooxygenase activity	Cyp3a2	IDA		Rat	PMID:12971802|RGD:5129544
Molecular Function	GO:0016491	oxidoreductase activity	CYP3A5	IDA		Human	PMID:15039299
Molecular Function	GO:0005515	protein binding	CYP3A5	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0008401	retinoic acid 4-hydroxylase activity	CYP3A5	IDA		Human	PMID:11093772
Molecular Function	GO:0050649	testosterone 6-beta-hydroxylase activity	Cyp3a23-3a1	IDA		Rat	PMID:9989933|RGD:2301703
Molecular Function	GO:0050649	testosterone 6-beta-hydroxylase activity	Cyp3a2	IMP		Rat	PMID:7979376|RGD:1299409
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Cyp3a23-3a1	IDA		Rat	PMID:8841512|RGD:1298226
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Cyp3a23-3a1	IDA		Rat	PMID:8841512|RGD:1298226
Biological Process	GO:0007568	aging	Cyp3a23-3a1	IEP		Rat	PMID:16207635|RGD:1625392
Biological Process	GO:0009822	alkaloid catabolic process	CYP3A5	IDA		Human	PMID:15039299
Biological Process	GO:0008210	estrogen metabolic process	CYP3A5	IDA		Human	PMID:12865317
Biological Process	GO:0002933	lipid hydroxylation	CYP3A5	IDA		Human	PMID:14559847
Biological Process	GO:0070989	oxidative demethylation	CYP3A5	IDA		Human	PMID:15039299
Biological Process	GO:0070989	oxidative demethylation	Cyp3a23-3a1	IDA		Rat	PMID:12971802|RGD:5129544
Biological Process	GO:0070989	oxidative demethylation	Cyp3a2	IDA		Rat	PMID:12971802|RGD:5129544
Biological Process	GO:0010468	regulation of gene expression	Cyp3a41a	IDA		Mouse	PMID:18794335
Biological Process	GO:0009617	response to bacterium	Cyp3a41a	IEP		Mouse	PMID:23012479
Biological Process	GO:0046686	response to cadmium ion	Cyp3a23-3a1	IEP		Rat	PMID:14595535|RGD:1599661
Biological Process	GO:0071548	response to dexamethasone	Cyp3a23-3a1	IEP		Rat	PMID:27856527|RGD:127285625
Biological Process	GO:0051384	response to glucocorticoid	Cyp3a23-3a1	IEP		Rat	PMID:15349958|RGD:1625399
Biological Process	GO:0010038	response to metal ion	Cyp3a23-3a1	IEP		Rat	PMID:16039771|RGD:1625395
Biological Process	GO:0007584	response to nutrient	Cyp3a23-3a1	IEP		Rat	PMID:16380645|RGD:1625391
Biological Process	GO:0009410	response to xenobiotic stimulus	Cyp3a23-3a1	IEP		Rat	PMID:17484520|RGD:1625389
Biological Process	GO:0009410	response to xenobiotic stimulus	cyp3a65	IDA		Zfish	PMID:15922010
Biological Process	GO:0042573	retinoic acid metabolic process	CYP3A5	IDA		Human	PMID:11093772
Biological Process	GO:0008202	steroid metabolic process	CYP3A5	IDA		Human	PMID:14559847
Biological Process	GO:0042178	xenobiotic catabolic process	CYP3A5	IDA		Human	PMID:15039299
Biological Process	GO:0006805	xenobiotic metabolic process	Cyp3a23-3a1	IDA		Rat	PMID:12971802|RGD:5129544
Biological Process	GO:0006805	xenobiotic metabolic process	Cyp3a2	IDA		Rat	PMID:12971802|RGD:5129544

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern