Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP3A43,CYP3A7,CYP3A7-CYP3A51P
  • Mouse genes Cyp3a59
  • Rat genes Cyp3a18
  • Zfish genes cyp3a65,cyp3c1,cyp3c3,cyp3c4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp3a59

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0101020	estrogen 16-alpha-hydroxylase activity	CYP3A7	IDA		Human	PMID:14559847
Molecular Function	GO:0101021	estrogen 2-hydroxylase activity	CYP3A7	IDA		Human	PMID:12865317
Molecular Function	GO:0020037	heme binding	cyp3c1	IDA		Zfish	PMID:16414346
Molecular Function	GO:0008401	retinoic acid 4-hydroxylase activity	CYP3A7	IDA		Human	PMID:11093772
Molecular Function	GO:0008395	steroid hydroxylase activity	CYP3A7	IDA		Human	PMID:14559847
Molecular Function	GO:0008390	testosterone 16-alpha-hydroxylase activity	Cyp3a18	IDA		Rat	PMID:8845857|RGD:727620
Molecular Function	GO:0050649	testosterone 6-beta-hydroxylase activity	Cyp3a18	IDA		Rat	PMID:8845857|RGD:727620
Biological Process	GO:0008210	estrogen metabolic process	CYP3A7	IDA		Human	PMID:12865317
Biological Process	GO:0008210	estrogen metabolic process	CYP3A7	IDA		Human	PMID:14559847
Biological Process	GO:0002933	lipid hydroxylation	CYP3A7	IDA		Human	PMID:14559847
Biological Process	GO:0009410	response to xenobiotic stimulus	cyp3a65	IDA		Zfish	PMID:15922010
Biological Process	GO:0042573	retinoic acid metabolic process	CYP3A7	IDA		Human	PMID:11093772
Biological Process	GO:0008202	steroid metabolic process	CYP3A7	IDA		Human	PMID:14559847

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern