Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP46A1
  • Mouse genes Cyp46a1
  • Rat genes Cyp46a1
  • Zfish genes cyp46a1.1,cyp46a1.2,cyp46a1.3,cyp46a1.4,zgc:123299
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp46a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0033781	cholesterol 24-hydroxylase activity	CYP46A1	IDA		Human	PMID:14640697
Molecular Function	GO:0033781	cholesterol 24-hydroxylase activity	CYP46A1	IDA		Human	PMID:18621681
Molecular Function	GO:0033781	cholesterol 24-hydroxylase activity	CYP46A1	IDA		Human	PMID:25017465
Molecular Function	GO:0033781	cholesterol 24-hydroxylase activity	Cyp46a1	IDA		Mouse	MGI:MGI:1339884|PMID:10377398
Molecular Function	GO:0020037	heme binding	CYP46A1	IDA		Human	PMID:18621681
Molecular Function	GO:0020037	heme binding	CYP46A1	IDA		Human	PMID:20667828
Molecular Function	GO:0020037	heme binding	CYP46A1	IDA		Human	PMID:23288837
Molecular Function	GO:0008395	steroid hydroxylase activity	CYP46A1	IDA		Human	PMID:14640697
Cellular Component	GO:0030425	dendrite	Cyp46a1	IDA		Mouse	MGI:MGI:6274953|PMID:18241055
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Cyp46a1	IDA		Mouse	MGI:MGI:6274953|PMID:18241055
Cellular Component	GO:0098794	postsynapse	Cyp46a1	IDA		Mouse	MGI:MGI:3620343|PMID:16505352
Cellular Component	GO:0098793	presynapse	Cyp46a1	IDA		Mouse	MGI:MGI:3620343|PMID:16505352
Biological Process	GO:0006707	cholesterol catabolic process	CYP46A1	IDA		Human	PMID:14640697
Biological Process	GO:0006707	cholesterol catabolic process	CYP46A1	IDA		Human	PMID:18621681
Biological Process	GO:0006707	cholesterol catabolic process	CYP46A1	IDA		Human	PMID:25017465
Biological Process	GO:0006707	cholesterol catabolic process	Cyp46a1	IDA		Mouse	MGI:MGI:6393037|PMID:20193040
Biological Process	GO:0006707	cholesterol catabolic process	Cyp46a1	IDA		Mouse	MGI:MGI:1339884|PMID:10377398
Biological Process	GO:0042448	progesterone metabolic process	CYP46A1	IDA		Human	PMID:14640697
Biological Process	GO:1903044	protein localization to membrane raft	Cyp46a1	IDA		Mouse	MGI:MGI:6393037|PMID:20193040
Biological Process	GO:1900271	regulation of long-term synaptic potentiation	Cyp46a1	IMP		Mouse	MGI:MGI:3620343|PMID:16505352
Biological Process	GO:0006805	xenobiotic metabolic process	CYP46A1	IDA		Human	PMID:20667828

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern