Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP4A11,CYP4A22
  • Mouse genes Cyp4a12a
  • Rat genes Cyp4a8
  • Zfish genes cyp4t8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp4a12a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0103002	16-hydroxypalmitate dehydrogenase activity	CYP4A22	IDA		Human	PMID:10860550
Molecular Function	GO:0018685	alkane 1-monooxygenase activity	CYP4A11	IDA		Human	PMID:18433732
Molecular Function	GO:0018685	alkane 1-monooxygenase activity	Cyp4a12a	IDA		Mouse	PMID:15313227
Molecular Function	GO:0008392	arachidonic acid epoxygenase activity	CYP4A11	IDA		Human	PMID:9618440
Molecular Function	GO:0052869	arachidonic acid omega-hydroxylase activity	Cyp4a12a	IDA		Mouse	MGI:MGI:3709948|PMID:17112342
Molecular Function	GO:0120250	fatty acid omega-hydroxylase activity	Cyp4a8	IDA		Rat	PMID:15618658|RGD:2303409
Molecular Function	GO:0050051	leukotriene-B4 20-monooxygenase activity	CYP4A11	IDA		Human	PMID:9799565
Molecular Function	GO:0102033	long-chain fatty acid omega-hydroxylase activity	CYP4A11	IDA		Human	PMID:15145985
Molecular Function	GO:0140981	medium-chain fatty acid omega-hydroxylase activity	CYP4A22	IDA		Human	PMID:10860550
Molecular Function	GO:0004497	monooxygenase activity	Cyp4a8	IDA		Rat	PMID:11139583|RGD:8554841
Cellular Component	GO:0016324	apical plasma membrane	CYP4A11	IDA		Human	PMID:10660572
Cellular Component	GO:0005737	cytoplasm	CYP4A11	IDA		Human	PMID:10660572
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Cyp4a8	IDA		Rat	PMID:15618658|RGD:2303409
Cellular Component	GO:0005615	extracellular space	CYP4A22	IDA		Human	PMID:16806293
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CYP4A11	IDA		Human	PMID:10660572
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CYP4A11	IDA		Human	PMID:9618440
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CYP4A11	IDA		Human	PMID:9799565
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Cyp4a8	IDA		Rat	PMID:15618658|RGD:2303409
Biological Process	GO:0019369	arachidonic acid metabolic process	CYP4A11	IDA		Human	PMID:10660572
Biological Process	GO:0019369	arachidonic acid metabolic process	Cyp4a8	IDA		Rat	PMID:15618658|RGD:2303409
Biological Process	GO:0019373	epoxygenase P450 pathway	CYP4A11	IDA		Human	PMID:9618440
Biological Process	GO:0006631	fatty acid metabolic process	Cyp4a8	IDA		Rat	PMID:11139583|RGD:8554841
Biological Process	GO:0001822	kidney development	Cyp4a8	IEP		Rat	PMID:9281597|RGD:2303411
Biological Process	GO:0048252	lauric acid metabolic process	Cyp4a8	IDA		Rat	PMID:10362749|RGD:2303410
Biological Process	GO:0048252	lauric acid metabolic process	Cyp4a8	IDA		Rat	PMID:15618658|RGD:2303409
Biological Process	GO:0006691	leukotriene metabolic process	CYP4A11	IDA		Human	PMID:9799565
Biological Process	GO:0002933	lipid hydroxylation	CYP4A22	IDA		Human	PMID:10860550
Biological Process	GO:0001676	long-chain fatty acid metabolic process	CYP4A11	IDA		Human	PMID:18433732
Biological Process	GO:0097267	omega-hydroxylase P450 pathway	Cyp4a12a	IDA		Mouse	MGI:MGI:3709948|PMID:17112342
Biological Process	GO:0032305	positive regulation of icosanoid secretion	CYP4A11	IMP		Human	PMID:18391101
Biological Process	GO:0003095	pressure natriuresis	CYP4A11	IEP		Human	PMID:10660572
Biological Process	GO:0003091	renal water homeostasis	CYP4A11	IEP		Human	PMID:10660572
Biological Process	GO:0033574	response to testosterone	Cyp4a8	IEP		Rat	PMID:18276983|RGD:2303382
Biological Process	GO:0055078	sodium ion homeostasis	CYP4A11	IEP		Human	PMID:10660572

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern