Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP7A1
  • Mouse genes Cyp7a1
  • Rat genes Cyp7a1
  • Zfish genes cyp7a1,cyp7a1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp7a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008123	cholesterol 7-alpha-monooxygenase activity	CYP7A1	IDA		Human	PMID:12077124
Molecular Function	GO:0008123	cholesterol 7-alpha-monooxygenase activity	Cyp7a1	IDA		Mouse	PMID:15845870
Molecular Function	GO:0008123	cholesterol 7-alpha-monooxygenase activity	Cyp7a1	IDA		Mouse	PMID:12114517
Molecular Function	GO:0008123	cholesterol 7-alpha-monooxygenase activity	Cyp7a1	IDA		Mouse	PMID:11279518
Molecular Function	GO:0008123	cholesterol 7-alpha-monooxygenase activity	Cyp7a1	IDA		Rat	PMID:1694852|RGD:70534
Molecular Function	GO:0008123	cholesterol 7-alpha-monooxygenase activity	Cyp7a1	IDA		Rat	PMID:2335522|RGD:70535
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Cyp7a1	IDA		Rat	PMID:16081591|RGD:1599972
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Cyp7a1	IDA		Rat	PMID:1694852|RGD:70534
Biological Process	GO:0015721	bile acid and bile salt transport	Cyp7a1	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0006699	bile acid biosynthetic process	CYP7A1	IDA		Human	PMID:19965590
Biological Process	GO:0006699	bile acid biosynthetic process	Cyp7a1	IDA		Rat	PMID:1694852|RGD:70534
Biological Process	GO:0038183	bile acid signaling pathway	Cyp7a1	IEP		Rat	PMID:30223280|RGD:15045612
Biological Process	GO:0071397	cellular response to cholesterol	Cyp7a1	IDA		Rat	PMID:1694852|RGD:70534
Biological Process	GO:0071333	cellular response to glucose stimulus	CYP7A1	IDA		Human	PMID:19965590
Biological Process	GO:0006707	cholesterol catabolic process	Cyp7a1	IDA		Mouse	PMID:15845870
Biological Process	GO:0006707	cholesterol catabolic process	Cyp7a1	IDA		Mouse	PMID:11279518
Biological Process	GO:0006707	cholesterol catabolic process	Cyp7a1	IDA		Rat	PMID:1694852|RGD:70534
Biological Process	GO:0042632	cholesterol homeostasis	Cyp7a1	IDA		Rat	PMID:1694852|RGD:70534
Biological Process	GO:0032966	negative regulation of collagen biosynthetic process	Cyp7a1	IMP		Rat	PMID:15521018|RGD:15045602
Biological Process	GO:0045717	negative regulation of fatty acid biosynthetic process	Cyp7a1	IDA		Rat	PMID:23536474|RGD:13792517
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	Cyp7a1	IDA		Rat	PMID:23536474|RGD:13792517
Biological Process	GO:0070857	regulation of bile acid biosynthetic process	CYP7A1	IDA		Human	PMID:19965590
Biological Process	GO:0070857	regulation of bile acid biosynthetic process	Cyp7a1	IDA		Rat	PMID:1694852|RGD:70534
Biological Process	GO:0010468	regulation of gene expression	Cyp7a1	IMP		Rat	PMID:15521018|RGD:15045602
Biological Process	GO:0045471	response to ethanol	Cyp7a1	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0014070	response to organic cyclic compound	Cyp7a1	IEP		Rat	PMID:27939985|RGD:15036816

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern