Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP8B1
  • Mouse genes Cyp8b1
  • Rat genes Cyp8b1
  • Zfish genes cyp8b1,cyp8b2,cyp8b3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp8b1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008397	sterol 12-alpha-hydroxylase activity	Cyp8b1	IDA		Rat	PMID:10393316|RGD:70706
Biological Process	GO:0006699	bile acid biosynthetic process	Cyp8b1	IMP		Mouse	MGI:MGI:3588413|PMID:12393855
Biological Process	GO:0038183	bile acid signaling pathway	Cyp8b1	IEP		Rat	PMID:25263431|RGD:15045610
Biological Process	GO:0045797	positive regulation of intestinal cholesterol absorption	Cyp8b1	IDA		Mouse	MGI:MGI:3588413|PMID:12393855
Biological Process	GO:0070723	response to cholesterol	Cyp8b1	IEP		Rat	PMID:25263431|RGD:15045610
Biological Process	GO:0031667	response to nutrient levels	Cyp8b1	IEP		Rat	PMID:25263431|RGD:15045610

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern