Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes D2HGDH
  • Mouse genes D2hgdh
  • Rat genes D2hgdh
  • Zfish genes d2hgdh
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set D2hgdh

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051990	(R)-2-hydroxyglutarate dehydrogenase activity	D2HGDH	EXP		Human	PMID:15070399
Molecular Function	GO:0051990	(R)-2-hydroxyglutarate dehydrogenase activity	D2HGDH	IMP		Human	PMID:20020533
Molecular Function	GO:0051990	(R)-2-hydroxyglutarate dehydrogenase activity	D2HGDH	IMP		Human	PMID:33431826
Molecular Function	GO:0051990	(R)-2-hydroxyglutarate dehydrogenase activity	D2hgdh	IDA		Rat	PMID:15070399|RGD:8553974
Molecular Function	GO:0008270	zinc ion binding	D2HGDH	IDA		Human	PMID:33431826
Cellular Component	GO:0005739	mitochondrion	D2HGDH	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	D2hgdh	IDA		Rat	PMID:15070399|RGD:8553974
Biological Process	GO:0006108	malate metabolic process	D2HGDH	IDA		Human	PMID:33431826
Biological Process	GO:0019538	protein metabolic process	D2hgdh	IDA		Rat	PMID:15070399|RGD:8553974
Biological Process	GO:0032025	response to cobalt ion	D2hgdh	IDA		Rat	PMID:15070399|RGD:8553974
Biological Process	GO:0010042	response to manganese ion	D2hgdh	IDA		Rat	PMID:15070399|RGD:8553974
Biological Process	GO:0010043	response to zinc ion	D2hgdh	IDA		Rat	PMID:15070399|RGD:8553974

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern