Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Dab2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes DAB2
- Mouse genes Dab2
- Rat genes Dab2
- Zfish genes dab2,si:ch211-204c21.1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dab2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035612	AP-2 adaptor complex binding	Dab2	IDA		Mouse	MGI:MGI:5442514\|PMID:12234931
Molecular Function	GO:0038024	cargo receptor activity	DAB2	IMP		Human	PMID:16984970
Molecular Function	GO:0038024	cargo receptor activity	Dab2	IDA		Mouse	MGI:MGI:5442508\|PMID:16984970
Molecular Function	GO:0035615	clathrin adaptor activity	DAB2	IMP		Human	PMID:16984970
Molecular Function	GO:0035615	clathrin adaptor activity	Dab2	IDA		Mouse	MGI:MGI:5442508\|PMID:16984970
Molecular Function	GO:0030276	clathrin binding	Dab2	IDA		Mouse	MGI:MGI:5442514\|PMID:12234931
Molecular Function	GO:0005178	integrin binding	Dab2	IMP		Mouse	MGI:MGI:5442513\|PMID:15734730
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	Dab2	IPI	UniProtKB:P98158	Rat	PMID:16306401\|RGD:14697713
Molecular Function	GO:0035091	phosphatidylinositol binding	Dab2	IDA		Mouse	MGI:MGI:5442514\|PMID:12234931
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Dab2	IDA		Mouse	MGI:MGI:2675568\|PMID:12826668
Molecular Function	GO:0005515	protein binding	DAB2	IPI	UniProtKB:P84022	Human	PMID:11387212
Molecular Function	GO:0005515	protein binding	DAB2	IPI	UniProtKB:Q15796	Human	PMID:11387212
Molecular Function	GO:0005515	protein binding	DAB2	IPI	UniProtKB:Q9UM54	Human	PMID:11967127
Molecular Function	GO:0005515	protein binding	DAB2	IPI	UniProtKB:Q92997	Human	PMID:12805222
Molecular Function	GO:0005515	protein binding	DAB2	IPI	UniProtKB:P13569	Human	PMID:15247260
Molecular Function	GO:0005515	protein binding	DAB2	IPI	UniProtKB:Q9UM54	Human	PMID:15837803
Molecular Function	GO:0005515	protein binding	DAB2	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	DAB2	IPI	UniProtKB:P62993	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	DAB2	IPI	UniProtKB:P62993	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	DAB2	IPI	UniProtKB:O75581	Human	PMID:22491013
Molecular Function	GO:0005515	protein binding	DAB2	IPI	UniProtKB:P42566	Human	PMID:22648170
Molecular Function	GO:0005515	protein binding	DAB2	IPI	UniProtKB:P00441	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DAB2	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DAB2	IPI	UniProtKB:P42566	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Dab2	IPI	UniProtKB:O94973\|UniProtKB:P62993\|UniProtKB:Q0JRZ9\|UniProtKB:Q9UM54	Mouse	MGI:MGI:5431037\|PMID:22323290
Molecular Function	GO:0005515	protein binding	Dab2	IPI	UniProtKB:O35625	Mouse	MGI:MGI:5516186\|PMID:19581931
Molecular Function	GO:0005515	protein binding	Dab2	IPI	UniProtKB:O35625\|UniProtKB:Q92997	Mouse	MGI:MGI:2664441\|PMID:12805222
Molecular Function	GO:0005515	protein binding	Dab2	IPI	UniProtKB:P42567\|UniProtKB:Q60902	Mouse	MGI:MGI:5448497\|PMID:22648170
Molecular Function	GO:0005515	protein binding	Dab2	IPI	UniProtKB:Q96B97	Mouse	MGI:MGI:5447624\|PMID:14596919
Molecular Function	GO:0005515	protein binding	Dab2	IPI	UniProtKB:Q6WKZ7	Mouse	MGI:MGI:3609432\|PMID:15596140
Molecular Function	GO:0005515	protein binding	Dab2	IPI	UniProtKB:P62993\|UniProtKB:Q60631	Mouse	MGI:MGI:5447634\|PMID:9569023
Molecular Function	GO:0005515	protein binding	Dab2	IPI	UniProtKB:P35917\|UniProtKB:Q99NH2-1	Mouse	MGI:MGI:5476876\|PMID:23354168
Molecular Function	GO:0005515	protein binding	Dab2	IPI	UniProtKB:Q9CR95	Mouse	MGI:MGI:5508601\|PMID:17762867
Molecular Function	GO:0005515	protein binding	Dab2	IPI	UniProtKB:Q9I8D1\|UniProtKB:Q9UM54	Mouse	MGI:MGI:5447627\|PMID:11967127
Molecular Function	GO:0005515	protein binding	Dab2	IPI	UniProtKB:O35625\|UniProtKB:Q60838\|UniProtKB:Q61062	Mouse	MGI:MGI:2664441\|PMID:12805222
Molecular Function	GO:0005515	protein binding	Dab2	IPI	PR:Q4KUS2	Mouse	PMID:10488064
Molecular Function	GO:0005515	protein binding	Dab2	IPI	UniProtKB:P98158	Rat	PMID:10769163\|RGD:7243160
Molecular Function	GO:0005515	protein binding	Dab2	IPI	RGD:621686	Rat	PMID:11812785\|RGD:632628
Molecular Function	GO:0005515	protein binding	Dab2	IPI	RGD:68407	Rat	PMID:11880330\|RGD:7243161
Molecular Function	GO:0005515	protein binding	Dab2	IPI	RGD:3140	Rat	PMID:19340093\|RGD:6902911
Molecular Function	GO:0005515	protein binding	Dab2	IPI	RGD:2081	Rat	PMID:22218591\|RGD:7243856
Molecular Function	GO:0005515	protein binding	Dab2	IPI	UniProtKB:P52800	Rat	PMID:23354168\|RGD:13432247
Molecular Function	GO:0046332	SMAD binding	DAB2	IDA		Human	PMID:11387212
Cellular Component	GO:0016324	apical plasma membrane	Dab2	IDA		Mouse	PMID:21146513
Cellular Component	GO:0030132	clathrin coat of coated pit	Dab2	IDA		Mouse	MGI:MGI:5442517\|PMID:11247302
Cellular Component	GO:0005905	clathrin-coated pit	DAB2	IDA		Human	PMID:12857860
Cellular Component	GO:0030136	clathrin-coated vesicle	DAB2	IDA		Human	PMID:19581412
Cellular Component	GO:0030665	clathrin-coated vesicle membrane	Dab2	IDA		Rat	PMID:19000037\|RGD:7243162
Cellular Component	GO:0001650	fibrillar center	DAB2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	DAB2	HDA		Human	PMID:21423176
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	DAB2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Dab2	IDA		Rat	PMID:21080337\|RGD:7243157
Cellular Component	GO:0005886	plasma membrane	DAB2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Dab2	IDA		Mouse	PMID:21146513
Cellular Component	GO:0005886	plasma membrane	Dab2	IDA		Rat	PMID:19000037\|RGD:7243162
Biological Process	GO:0001525	angiogenesis	dab2	IMP	ZFIN:ZDB-MRPHLNO-060919-1	Zfish	PMID:22898784
Biological Process	GO:0000904	cell morphogenesis involved in differentiation	Dab2	IMP	MGI:MGI:2429678	Mouse	PMID:12413896
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	Dab2	IDA		Rat	PMID:12473651\|RGD:8553624
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Dab2	IDA		Mouse	MGI:MGI:5442513\|PMID:15734730
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Dab2	IDA		Mouse	MGI:MGI:5442512\|PMID:15894542
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Dab2	IEP		Rat	PMID:21762377\|RGD:7243156
Biological Process	GO:0048268	clathrin coat assembly	Dab2	IDA		Mouse	MGI:MGI:5442514\|PMID:12234931
Biological Process	GO:0048268	clathrin coat assembly	Dab2	IMP		Rat	PMID:19000037\|RGD:7243162
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Dab2	IMP		Mouse	PMID:15734730
Biological Process	GO:0071425	hematopoietic stem cell proliferation	Dab2	IDA		Mouse	PMID:29925839
Biological Process	GO:0001701	in utero embryonic development	Dab2	IMP	MGI:MGI:2429678	Mouse	PMID:12413896
Biological Process	GO:0035026	leading edge cell differentiation	DAB2	IMP		Human	PMID:19581412
Biological Process	GO:0030099	myeloid cell differentiation	Dab2	IEP		Mouse	MGI:MGI:2158858\|PMID:11823414
Biological Process	GO:0060766	negative regulation of androgen receptor signaling pathway	DAB2	IMP		Human	PMID:16267015
Biological Process	GO:0043066	negative regulation of apoptotic process	DAB2	IDA		Human	PMID:15734730
Biological Process	GO:0043066	negative regulation of apoptotic process	Dab2	IMP		Mouse	MGI:MGI:5442513\|PMID:15734730
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	DAB2	IMP		Human	PMID:12805222
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Dab2	IGI	RNAcentral:URS0000527F89_10116	Rat	PMID:21762377\|RGD:7243156
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	dab2	IMP	ZFIN:ZDB-CRISPR-160331-1	Zfish	PMID:26755607
Biological Process	GO:0030308	negative regulation of cell growth	Dab2	IMP		Rat	PMID:11371563\|RGD:1302365
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Dab2	IDA		Rat	PMID:9681506\|RGD:728288
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Dab2	IDA		Rat	PMID:12473651\|RGD:8553624
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	Dab2	IMP		Mouse	PMID:15734730
Biological Process	GO:0010977	negative regulation of neuron projection development	Dab2	IDA		Rat	PMID:17317100\|RGD:7243246
Biological Process	GO:0032091	negative regulation of protein binding	DAB2	IMP		Human	PMID:12805222
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	DAB2	IMP		Human	PMID:19581412
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	Dab2	IMP		Mouse	MGI:MGI:3850744\|PMID:19581412
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	DAB2	IMP		Human	PMID:12805222
Biological Process	GO:0007219	Notch signaling pathway	dab2	IGI	ZFIN:ZDB-GENO-980202-1107	Zfish	PMID:16999953
Biological Process	GO:0032349	positive regulation of aldosterone biosynthetic process	Dab2	IDA		Rat	PMID:17303656\|RGD:7243836
Biological Process	GO:2000860	positive regulation of aldosterone secretion	Dab2	IDA		Rat	PMID:17303656\|RGD:7243836
Biological Process	GO:0045785	positive regulation of cell adhesion	Dab2	IMP		Mouse	MGI:MGI:5442513\|PMID:15734730
Biological Process	GO:0045785	positive regulation of cell adhesion	Dab2	IDA		Mouse	MGI:MGI:2158858\|PMID:11823414
Biological Process	GO:0030335	positive regulation of cell migration	DAB2	IMP		Human	PMID:19581412
Biological Process	GO:0030335	positive regulation of cell migration	Dab2	IMP		Mouse	MGI:MGI:5442512\|PMID:15894542
Biological Process	GO:2000370	positive regulation of clathrin-dependent endocytosis	DAB2	IMP		Human	PMID:16984970
Biological Process	GO:2000370	positive regulation of clathrin-dependent endocytosis	Dab2	IDA		Mouse	MGI:MGI:5442508\|PMID:16984970
Biological Process	GO:2000643	positive regulation of early endosome to late endosome transport	DAB2	IMP		Human	PMID:21995445
Biological Process	GO:0045807	positive regulation of endocytosis	DAB2	IMP		Human	PMID:19581412
Biological Process	GO:0045807	positive regulation of endocytosis	DAB2	IMP		Human	PMID:21995445
Biological Process	GO:0045807	positive regulation of endocytosis	Dab2	IDA		Rat	PMID:19000037\|RGD:7243162
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	DAB2	IDA		Human	PMID:15734730
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	Dab2	IMP		Mouse	MGI:MGI:5442513\|PMID:15734730
Biological Process	GO:2001046	positive regulation of integrin-mediated signaling pathway	Dab2	IMP		Mouse	MGI:MGI:5442513\|PMID:15734730
Biological Process	GO:0046330	positive regulation of JNK cascade	Dab2	IDA		Mouse	MGI:MGI:5442512\|PMID:15894542
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	DAB2	IDA		Human	PMID:11387212
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	Dab2	IMP		Mouse	MGI:MGI:5317100\|PMID:20881059
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	DAB2	IMP		Human	PMID:12805222
Biological Process	GO:0001934	positive regulation of protein phosphorylation	DAB2	IMP		Human	PMID:12805222
Biological Process	GO:0002092	positive regulation of receptor internalization	Dab2	IMP		Mouse	MGI:MGI:5476876\|PMID:23354168
Biological Process	GO:0001921	positive regulation of receptor recycling	Dab2	IMP		Mouse	MGI:MGI:5317100\|PMID:20881059
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	DAB2	IDA		Human	PMID:11387212
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	Dab2	IMP		Mouse	MGI:MGI:5442513\|PMID:15734730
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	Dab2	IDA		Mouse	MGI:MGI:2158858\|PMID:11823414
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	Dab2	IMP		Rat	PMID:19000037\|RGD:7243162
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	DAB2	IMP		Human	PMID:12805222
Biological Process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	Dab2	IMP		Mouse	MGI:MGI:5442512\|PMID:15894542
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	DAB2	IDA		Human	PMID:11387212
Biological Process	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway	DAB2	IMP		Human	PMID:12805222
Biological Process	GO:0006898	receptor-mediated endocytosis	Dab2	IPI	UniProtKB:P70215	Mouse	PMID:12413896
Biological Process	GO:0006898	receptor-mediated endocytosis	dab2	IMP	ZFIN:ZDB-MRPHLNO-060919-1	Zfish	PMID:16638803
Biological Process	GO:0030510	regulation of BMP signaling pathway	dab2	IMP	ZFIN:ZDB-MRPHLNO-060919-1	Zfish	PMID:22898784
Biological Process	GO:2000725	regulation of cardiac muscle cell differentiation	dab2	IMP	ZFIN:ZDB-CRISPR-160331-1	Zfish	PMID:26755607
Biological Process	GO:2000298	regulation of Rho-dependent protein serine/threonine kinase activity	Dab2	IDA		Rat	PMID:9681506\|RGD:728288
Biological Process	GO:0097017	renal protein absorption	Dab2	IMP	MGI:MGI:2387168	Mouse	PMID:11927540
Biological Process	GO:1902074	response to salt	Dab2	IEP		Rat	PMID:17303656\|RGD:7243836
Biological Process	GO:0048545	response to steroid hormone	Dab2	IMP		Rat	PMID:9681506\|RGD:728288
Biological Process	GO:0001944	vasculature development	dab2	IGI	ZFIN:ZDB-MRPHLNO-060919-1,ZFIN:ZDB-MRPHLNO-110729-1	Zfish	PMID:22898784
Biological Process	GO:0001944	vasculature development	dab2	IMP	ZFIN:ZDB-MRPHLNO-060919-1	Zfish	PMID:22898784

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.