Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Dab2ip

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes DAB2IP
- Mouse genes Dab2ip
- Rat genes Dab2ip
- Zfish genes dab2ipa,dab2ipb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dab2ip

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	DAB2IP	IDA		Human	PMID:17389591
Molecular Function	GO:0045296	cadherin binding	DAB2IP	HDA		Human	PMID:25468996
Molecular Function	GO:0005123	death receptor binding	DAB2IP	IPI	UniProtKB:O19131	Human	PMID:15310755
Molecular Function	GO:0005096	GTPase activator activity	Dab2ip	IDA		Rat	PMID:11812785\|RGD:632628
Molecular Function	GO:0042802	identical protein binding	DAB2IP	IPI	UniProtKB:Q5VWQ8	Human	PMID:12813029
Molecular Function	GO:0019900	kinase binding	DAB2IP	IPI	UniProtKB:Q13546	Human	PMID:17389591
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	DAB2IP	IPI	UniProtKB:Q99683	Human	PMID:17389591
Molecular Function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	DAB2IP	IPI	UniProtKB:Q99683	Human	PMID:12813029
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	DAB2IP	IDA		Human	PMID:19033661
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	DAB2IP	IDA		Human	PMID:19903888
Molecular Function	GO:0032266	phosphatidylinositol-3-phosphate binding	DAB2IP	IDA		Human	PMID:19948740
Molecular Function	GO:0070273	phosphatidylinositol-4-phosphate binding	DAB2IP	IDA		Human	PMID:19948740
Molecular Function	GO:0005515	protein binding	DAB2IP	IPI	UniProtKB:Q99683	Human	PMID:12813029
Molecular Function	GO:0005515	protein binding	DAB2IP	IPI	UniProtKB:Q12933	Human	PMID:17389591
Molecular Function	GO:0005515	protein binding	DAB2IP	IPI	UniProtKB:P31749	Human	PMID:19903888
Molecular Function	GO:0005515	protein binding	DAB2IP	IPI	UniProtKB:P49841	Human	PMID:20080667
Molecular Function	GO:0005515	protein binding	DAB2IP	IPI	UniProtKB:P67775	Human	PMID:20080667
Molecular Function	GO:0005515	protein binding	Dab2ip	IPI	UniProtKB:P39429,UniProtKB:Q9EQY0	Mouse	MGI:MGI:3796479\|PMID:18281285
Molecular Function	GO:0005515	protein binding	Dab2ip	IPI	PR:P97318	Mouse	PMID:12877983
Molecular Function	GO:0005515	protein binding	Dab2ip	IPI	RGD:621007	Rat	PMID:11812785\|RGD:632628
Molecular Function	GO:0042803	protein homodimerization activity	DAB2IP	IPI	UniProtKB:Q5VWQ8	Human	PMID:12813029
Molecular Function	GO:0019901	protein kinase binding	DAB2IP	IDA		Human	PMID:18281285
Molecular Function	GO:0019901	protein kinase binding	DAB2IP	IPI	UniProtKB:P49841	Human	PMID:20080667
Molecular Function	GO:0019901	protein kinase binding	Dab2ip	IPI	UniProtKB:Q9EQY0	Mouse	MGI:MGI:3796479\|PMID:18281285
Molecular Function	GO:0051721	protein phosphatase 2A binding	DAB2IP	IDA		Human	PMID:20080667
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	DAB2IP	IDA		Human	PMID:19903888
Molecular Function	GO:0044877	protein-containing complex binding	DAB2IP	IDA		Human	PMID:19903888
Molecular Function	GO:0017124	SH3 domain binding	DAB2IP	IDA		Human	PMID:19033661
Molecular Function	GO:0035591	signaling adaptor activity	DAB2IP	IDA		Human	PMID:19903888
Molecular Function	GO:0035591	signaling adaptor activity	DAB2IP	IDA		Human	PMID:20080667
Molecular Function	GO:0043184	vascular endothelial growth factor receptor 2 binding	DAB2IP	IPI	UniProtKB:P35968	Human	PMID:19033661
Cellular Component	GO:1990597	AIP1-IRE1 complex	DAB2IP	IDA		Human	PMID:18281285
Cellular Component	GO:1990597	AIP1-IRE1 complex	Dab2ip	IPI	UniProtKB:Q9EQY0	Mouse	MGI:MGI:3796479\|PMID:18281285
Cellular Component	GO:0030424	axon	Dab2ip	IDA		Mouse	MGI:MGI:5486089\|PMID:23326475
Cellular Component	GO:0044300	cerebellar mossy fiber	Dab2ip	IDA		Mouse	MGI:MGI:5486089\|PMID:23326475
Cellular Component	GO:0044301	climbing fiber	Dab2ip	IDA		Mouse	MGI:MGI:5486089\|PMID:23326475
Cellular Component	GO:0005737	cytoplasm	DAB2IP	IDA		Human	PMID:15310755
Cellular Component	GO:0005737	cytoplasm	DAB2IP	IDA		Human	PMID:19948740
Cellular Component	GO:0005737	cytoplasm	Dab2ip	IDA		Mouse	MGI:MGI:4453088\|PMID:19948740
Cellular Component	GO:0005737	cytoplasm	Dab2ip	IDA		Mouse	MGI:MGI:5463669\|PMID:23056358
Cellular Component	GO:0030139	endocytic vesicle	DAB2IP	IDA		Human	PMID:19948740
Cellular Component	GO:0043025	neuronal cell body	Dab2ip	IDA		Mouse	MGI:MGI:5486089\|PMID:23326475
Cellular Component	GO:0032809	neuronal cell body membrane	Dab2ip	IDA		Mouse	MGI:MGI:5463669\|PMID:23056358
Cellular Component	GO:1990032	parallel fiber	Dab2ip	IDA		Mouse	MGI:MGI:5486089\|PMID:23326475
Cellular Component	GO:0005886	plasma membrane	DAB2IP	IDA		Human	PMID:15310755
Cellular Component	GO:0005886	plasma membrane	DAB2IP	IDA		Human	PMID:19948740
Cellular Component	GO:0005886	plasma membrane	Dab2ip	IDA		Mouse	MGI:MGI:4453088\|PMID:19948740
Cellular Component	GO:0005886	plasma membrane	Dab2ip	IDA		Mouse	MGI:MGI:5463669\|PMID:23056358
Biological Process	GO:0021814	cell motility involved in cerebral cortex radial glia guided migration	Dab2ip	IMP		Mouse	MGI:MGI:5463669\|PMID:23056358
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	Dab2ip	IDA		Rat	PMID:11812785\|RGD:632628
Biological Process	GO:0071347	cellular response to interleukin-1	DAB2IP	IDA		Human	PMID:19948740
Biological Process	GO:0071347	cellular response to interleukin-1	Dab2ip	IDA		Mouse	MGI:MGI:4453088\|PMID:19948740
Biological Process	GO:0071222	cellular response to lipopolysaccharide	DAB2IP	IDA		Human	PMID:19948740
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Dab2ip	IDA		Mouse	MGI:MGI:4453088\|PMID:19948740
Biological Process	GO:0071356	cellular response to tumor necrosis factor	DAB2IP	IDA		Human	PMID:12813029
Biological Process	GO:0071356	cellular response to tumor necrosis factor	DAB2IP	IDA		Human	PMID:15310755
Biological Process	GO:0071356	cellular response to tumor necrosis factor	DAB2IP	IDA		Human	PMID:17389591
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Dab2ip	IMP		Mouse	MGI:MGI:4398763\|PMID:19903888
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Dab2ip	IMP		Mouse	MGI:MGI:3796479\|PMID:18281285
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	DAB2IP	IDA		Human	PMID:19033661
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	Dab2ip	IDA		Mouse	MGI:MGI:3831615\|PMID:19033661
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	DAB2IP	IMP		Human	PMID:19903888
Biological Process	GO:0007252	I-kappaB phosphorylation	Dab2ip	IMP		Mouse	MGI:MGI:4453088\|PMID:19948740
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Dab2ip	IMP		Mouse	MGI:MGI:3796479\|PMID:18281285
Biological Process	GO:0021819	layer formation in cerebral cortex	Dab2ip	IMP		Mouse	MGI:MGI:5463669\|PMID:23056358
Biological Process	GO:0016525	negative regulation of angiogenesis	DAB2IP	IDA		Human	PMID:19033661
Biological Process	GO:0016525	negative regulation of angiogenesis	Dab2ip	IMP		Mouse	MGI:MGI:3831615\|PMID:19033661
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	DAB2IP	IMP		Human	PMID:20080667
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Dab2ip	IMP		Mouse	MGI:MGI:4431163\|PMID:20080667
Biological Process	GO:0030308	negative regulation of cell growth	Dab2ip	IDA		Rat	PMID:11812785\|RGD:632628
Biological Process	GO:0008285	negative regulation of cell population proliferation	DAB2IP	IDA		Human	PMID:19903888
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	DAB2IP	IMP		Human	PMID:20080667
Biological Process	GO:0010596	negative regulation of endothelial cell migration	DAB2IP	IMP		Human	PMID:19033661
Biological Process	GO:0010596	negative regulation of endothelial cell migration	Dab2ip	IMP		Mouse	MGI:MGI:3831615\|PMID:19033661
Biological Process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	Dab2ip	IDA		Rat	PMID:11812785\|RGD:632628
Biological Process	GO:0010633	negative regulation of epithelial cell migration	DAB2IP	IMP		Human	PMID:20080667
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	DAB2IP	IMP		Human	PMID:20154697
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	DAB2IP	IMP		Human	PMID:20080667
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	DAB2IP	IDA		Human	PMID:20154697
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	DAB2IP	IDA		Human	PMID:19903888
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	Dab2ip	IMP		Mouse	MGI:MGI:4887526\|PMID:20154697
Biological Process	GO:0070317	negative regulation of G0 to G1 transition	DAB2IP	IDA		Human	PMID:19903888
Biological Process	GO:0034260	negative regulation of GTPase activity	DAB2IP	IMP		Human	PMID:20154697
Biological Process	GO:0034260	negative regulation of GTPase activity	Dab2ip	IMP		Mouse	MGI:MGI:4453088\|PMID:19948740
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	DAB2IP	IDA		Human	PMID:15310755
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	DAB2IP	IDA		Human	PMID:17389591
Biological Process	GO:0043407	negative regulation of MAP kinase activity	DAB2IP	IDA		Human	PMID:12813029
Biological Process	GO:0043407	negative regulation of MAP kinase activity	DAB2IP	IMP		Human	PMID:20154697
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	DAB2IP	IMP		Human	PMID:20154697
Biological Process	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity	DAB2IP	IDA		Human	PMID:19903888
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	DAB2IP	IDA		Human	PMID:19903888
Biological Process	GO:0042177	negative regulation of protein catabolic process	DAB2IP	IDA		Human	PMID:19903888
Biological Process	GO:0001933	negative regulation of protein phosphorylation	DAB2IP	IMP		Human	PMID:20080667
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Dab2ip	IMP		Mouse	MGI:MGI:3831615\|PMID:19033661
Biological Process	GO:0071901	negative regulation of protein serine/threonine kinase activity	DAB2IP	IDA		Human	PMID:19903888
Biological Process	GO:0071901	negative regulation of protein serine/threonine kinase activity	DAB2IP	IMP		Human	PMID:20154697
Biological Process	GO:0071901	negative regulation of protein serine/threonine kinase activity	Dab2ip	IMP		Mouse	MGI:MGI:4398763\|PMID:19903888
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	Dab2ip	IDA		Rat	PMID:11812785\|RGD:632628
Biological Process	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	DAB2IP	IDA		Human	PMID:19948740
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	DAB2IP	IDA		Human	PMID:15310755
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	DAB2IP	IMP		Human	PMID:20154697
Biological Process	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	DAB2IP	IMP		Human	PMID:19033661
Biological Process	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	Dab2ip	IMP		Mouse	MGI:MGI:3831615\|PMID:19033661
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	Dab2ip	IDA		Mouse	MGI:MGI:3831615\|PMID:19033661
Biological Process	GO:0048812	neuron projection morphogenesis	Dab2ip	IMP		Mouse	MGI:MGI:5463669\|PMID:23056358
Biological Process	GO:0043065	positive regulation of apoptotic process	DAB2IP	IDA		Human	PMID:17389591
Biological Process	GO:0043065	positive regulation of apoptotic process	DAB2IP	IDA		Human	PMID:19903888
Biological Process	GO:0043065	positive regulation of apoptotic process	Dab2ip	IMP		Mouse	MGI:MGI:4398763\|PMID:19903888
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	DAB2IP	IDA		Human	PMID:19903888
Biological Process	GO:1900006	positive regulation of dendrite development	Dab2ip	IMP		Mouse	MGI:MGI:5486089\|PMID:23326475
Biological Process	GO:0046330	positive regulation of JNK cascade	DAB2IP	IDA		Human	PMID:17389591
Biological Process	GO:0046330	positive regulation of JNK cascade	DAB2IP	IDA		Human	PMID:19903888
Biological Process	GO:0043507	positive regulation of JUN kinase activity	DAB2IP	IDA		Human	PMID:12813029
Biological Process	GO:0043507	positive regulation of JUN kinase activity	DAB2IP	IDA		Human	PMID:15310755
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Dab2ip	IMP		Mouse	MGI:MGI:3796479\|PMID:18281285
Biological Process	GO:0043410	positive regulation of MAPK cascade	DAB2IP	IDA		Human	PMID:19903888
Biological Process	GO:2001224	positive regulation of neuron migration	Dab2ip	IMP		Mouse	MGI:MGI:5463669\|PMID:23056358
Biological Process	GO:0010976	positive regulation of neuron projection development	Dab2ip	IMP		Mouse	MGI:MGI:5463669\|PMID:23056358
Biological Process	GO:1901800	positive regulation of proteasomal protein catabolic process	DAB2IP	IMP		Human	PMID:20080667
Biological Process	GO:0045732	positive regulation of protein catabolic process	Dab2ip	IMP		Mouse	MGI:MGI:4453088\|PMID:19948740
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	DAB2IP	IDA		Human	PMID:19903888
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	DAB2IP	IMP		Human	PMID:20080667
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	Dab2ip	IMP		Mouse	MGI:MGI:4398763\|PMID:19903888
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	Dab2ip	IMP		Mouse	MGI:MGI:4431163\|PMID:20080667
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	DAB2IP	IDA		Human	PMID:18281285
Biological Process	GO:0090129	positive regulation of synapse maturation	Dab2ip	IMP		Mouse	MGI:MGI:5486089\|PMID:23326475
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	DAB2IP	IDA		Human	PMID:15310755
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	DAB2IP	IDA		Human	PMID:17389591
Biological Process	GO:0030163	protein catabolic process	DAB2IP	IDA		Human	PMID:17389591
Biological Process	GO:0051726	regulation of cell cycle	DAB2IP	IDA		Human	PMID:19903888
Biological Process	GO:0043087	regulation of GTPase activity	Dab2ip	IMP		Mouse	MGI:MGI:4453088\|PMID:19948740
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	Dab2ip	IMP		Mouse	MGI:MGI:4453088\|PMID:19948740
Biological Process	GO:1900744	regulation of p38MAPK cascade	Dab2ip	IMP		Mouse	MGI:MGI:4453088\|PMID:19948740
Biological Process	GO:0043254	regulation of protein-containing complex assembly	DAB2IP	IDA		Human	PMID:19948740
Biological Process	GO:0043254	regulation of protein-containing complex assembly	Dab2ip	IMP		Mouse	MGI:MGI:4453088\|PMID:19948740
Biological Process	GO:0035148	tube formation	DAB2IP	IMP		Human	PMID:19033661
Biological Process	GO:0035148	tube formation	Dab2ip	IMP		Mouse	MGI:MGI:3831615\|PMID:19033661
Biological Process	GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway	Dab2ip	IMP		Mouse	MGI:MGI:3831615\|PMID:19033661

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.